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    CLC-D chloride channel D [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832693, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CLC-D
    Official Full Name
    chloride channel D
    Primary source
    TAIR:AT5G26240
    Locus tag
    AT5G26240
    See related
    Araport:AT5G26240
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATCLC-D; AtCLCd; chloride channel D; CHLORIDE CHANNEL D; CLCd; T19G15.90; T19G15_90
    Summary
    member of Anion channel protein family
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    Genomic context

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    See CLC-D in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    22
    Sequence:
    Chromosome: 5; NC_003076.8 (9189425..9194758)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene Major facilitator superfamily protein Neighboring gene TRAF-like family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Function of the anion transporter AtCLC-d in the trans-Golgi network. von der Fecht-Bartenbach J, et al. Plant J, 2007 May. PMID 17376158, Free PMC Article
    2. The chloride channel family gene CLCd negatively regulates pathogen-associated molecular pattern (PAMP)-triggered immunity in Arabidopsis. Guo W, et al. J Exp Bot, 2014 Mar. PMID 24449384, Free PMC Article
    3. A family of putative chloride channels from Arabidopsis and functional complementation of a yeast strain with a CLC gene disruption. Hechenberger M, et al. J Biol Chem, 1996 Dec 27. PMID 8969232
    4. Uncovering Arabidopsis membrane protein interactome enriched in transporters using mating-based split ubiquitin assays and classification models. Chen J, et al. Front Plant Sci, 2012. PMID 22737156, Free PMC Article
    5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AtCLCd negatively regulates pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI).
      Title: The chloride channel family gene CLCd negatively regulates pathogen-associated molecular pattern (PAMP)-triggered immunity in Arabidopsis.
    2. The functional role of CLC-D in the trans-Golgi network is reported.
      Title: Function of the anion transporter AtCLC-d in the trans-Golgi network.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001343969.1
    NM_122525.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables monoatomic anion channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables voltage-gated chloride channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated chloride channel activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    NOT involved_in intracellular monoatomic anion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to metal ion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within unidimensional cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in intracellular anatomical structure IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    chloride channel D
    NP_197996.1
    • chloride channel D (CLC-D); CONTAINS InterPro DOMAIN/s: Chloride channel, core (InterPro:IPR014743), Chloride channel, voltage gated (InterPro:IPR001807), Chloride channel ClC-plant (InterPro:IPR002251), Cystathionine beta-synthase, core (InterPro:IPR000644); BEST Arabidopsis thaliana protein match is: chloride channel C (TAIR:AT5G49890.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      9189425..9194758
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_122525.3 → NP_197996.1  chloride channel D [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197996.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81491, P92943
      UniProtKB/TrEMBL
      A0A178U6J2, A0A5S9Y7C2, A0A654G4J8
      Conserved Domains (2) summary
      cd03685
      Location:45 → 574
      ClC_6_like; ClC-6-like chloride channel proteins. This CD includes ClC-6, ClC-7 and ClC-B, C, D in plants. Proteins in this family are ubiquitous in eukarotes and their functions are unclear. They are expressed in intracellular organelles membranes. This family ...
      cd04591
      Location:593 → 751
      CBS_pair_voltage-gated_CLC_euk_bac; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteria

    2. NM_001343969.1 → NP_001330038.1  chloride channel D [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178U8S4, A0A1P8B9J9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P92943.2

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