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    ALS3 aluminum sensitive 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818310, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ALS3
    Official Full Name
    aluminum sensitive 3
    Primary source
    TAIR:AT2G37330
    Locus tag
    AT2G37330
    See related
    Araport:AT2G37330
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ALUMINUM SENSITIVE 3; F3G5.12; F3G5_12
    Summary
    Encodes an ABC transporter-like protein, without an ATPase domain, required for aluminum (Al) resistance/tolerance and may function to redistribute accumulated Al away from sensitive tissues in order to protect the growing root from the toxic effects of Al.
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    Genomic context

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    See ALS3 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    3
    Sequence:
    Chromosome: 2; NC_003071.7 (15669131..15670187)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene arginine/serine-rich zinc knuckle-containing protein 33 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ABC-2 type transporter family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression genome-wide association study identifies that phosphatidylinositol-derived signalling regulates ALUMINIUM SENSITIVE3 expression under aluminium stress in the shoots of Arabidopsis thaliana. Sadhukhan A, et al. Plant Sci, 2021 Jan. PMID 33288018
    2. An Arabidopsis ABC Transporter Mediates Phosphate Deficiency-Induced Remodeling of Root Architecture by Modulating Iron Homeostasis in Roots. Dong J, et al. Mol Plant, 2017 Feb 13. PMID 27847325
    3. Al Inhibits Both Shoot Development and Root Growth in als3, an Al-Sensitive Arabidopsis Mutant. Larsen PB, et al. Plant Physiol, 1997 Aug. PMID 12223767, Free PMC Article
    4. An ABC transporter complex encoded by Aluminum Sensitive 3 and NAP3 is required for phosphate deficiency responses in Arabidopsis. Belal R, et al. Biochem Biophys Res Commun, 2015 Jul 17-24. PMID 25983320
    5. Calmodulin-like protein CML24 interacts with CAMTA2 and WRKY46 to regulate ALMT1-dependent Al resistance in Arabidopsis thaliana. Zhu X, et al. New Phytol, 2022 Mar. PMID 34665465

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression genome-wide association study identifies that phosphatidylinositol-derived signalling regulates ALUMINIUM SENSITIVE3 expression under aluminium stress in the shoots of Arabidopsis thaliana.
      Title: Expression genome-wide association study identifies that phosphatidylinositol-derived signalling regulates ALUMINIUM SENSITIVE3 expression under aluminium stress in the shoots of Arabidopsis thaliana.
    2. evidence showing that ALS3 cooperates with LPR1/2 to regulate Pi deficiency-induced remodeling of root architecture by modulating Fe homeostasis in roots
      Title: An Arabidopsis ABC Transporter Mediates Phosphate Deficiency-Induced Remodeling of Root Architecture by Modulating Iron Homeostasis in Roots.
    3. ALS3 and NAP3 protein form an ABC transporter complex that is required for sugar-dependent response to phosphate deficiency.
      Title: An ABC transporter complex encoded by Aluminum Sensitive 3 and NAP3 is required for phosphate deficiency responses in Arabidopsis.
    4. The identification and expression of ALS3 gene, which encodes a transporter that is required for aluminum tolerance in Arabdiposis roots. [ALS3]
      Title: ALS3 encodes a phloem-localized ABC transporter-like protein that is required for aluminum tolerance in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_129289.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to aluminum ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    aluminum sensitive 3
    NP_181270.1
    • ALUMINUM SENSITIVE 3 (ALS3); CONTAINS InterPro DOMAIN/s: Conserved hypothetical protein CHP00245 (InterPro:IPR005226); Has 1906 Blast hits to 1906 proteins in 934 species: Archae - 39; Bacteria - 1722; Metazoa - 0; Fungi - 12; Plants - 43; Viruses - 0; Other Eukaryotes - 90 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      15669131..15670187
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129289.5 → NP_181270.1  aluminum sensitive 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_181270.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9ZUT3
      UniProtKB/TrEMBL
      A0A178VRI6, A0A5S9X4W9
      Conserved Domains (1) summary
      pfam03649
      Location:39 → 259
      UPF0014; Uncharacterized protein family (UPF0014)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZUT3.1

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