ESR1 Integrase-type DNA-binding superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: ESR1
Official Full Name: Integrase-type DNA-binding superfamily protein
Primary source: TAIR:AT1G12980
Locus tag: AT1G12980
See related: Araport:AT1G12980
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: DORNROSCHEN; DRN; ENHANCER OF SHOOT REGENERATION 1; F3F19.1; F3F19_1
Summary: Encodes an AP2/ERF protein, is expressed in a subdomain of meristem stem cells, in lateral organ anlagen, and transiently in the distal domain of organ primordia. It is a member of the ERF (ethylene response factor) subfamily B-1 of ERF/AP2 transcription factor family (ESR1). The protein contains one AP2 domain. There are 15 members in this subfamily including ATERF-3, ATERF-4, ATERF-7, and leafy petiole. Can confer cytokinin-independent shoot formation and causes severe meristem defects when overexpressed in Arabidopsis root explants. Involved in controlling embryogenesis and embryo patterning by interaction with PHAVOLUTA.
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Genomic context

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See ESR1 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 1

Sequence:: Chromosome: 1; NC_003070.9 (4429718..4430965)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ENHANCER OF SHOOT REGENERATION1 promotes de novo root organogenesis after wounding in Arabidopsis leaf explants.
Title: ENHANCER OF SHOOT REGENERATION1 promotes de novo root organogenesis after wounding in Arabidopsis leaf explants.
Post-Embryonic Lateral Organ Development and Adaxial-Abaxial Polarity Are Regulated by the Combined Effect of ENHANCER OF SHOOT REGENERATION 1 and WUSCHEL in Arabidopsis Shoots.
Title: Post-Embryonic Lateral Organ Development and Adaxial-Abaxial Polarity Are Regulated by the Combined Effect of ENHANCER OF SHOOT REGENERATION 1 and WUSCHEL in Arabidopsis Shoots.
Auxin signaling in stem cells is mediated, at least in part, by AUXIN RESPONSE FACTOR 5/MONOPTEROS (ARF5/MP), which directly represses the transcription of DORNROSCHEN/ENHANCER OF SHOOT REGENERATION 1 (DRN/ESR1). DRN expressed in stem cells positively regulates CLAVATA3 (CLV3) expression and has important meristematic functions.
Title: A Molecular Framework for Auxin-Controlled Homeostasis of Shoot Stem Cells in Arabidopsis.
The combined loss of function of DORNROSCHEN, DORNROSCHEN-LIKE, and PUCHI leads to synergistic floral phenotypes, including reduced floral merosity in all whorls, which reflects redundant functions of all three genes in organ initiation rather than outgrowth.
Title: DORNRÖSCHEN, DORNRÖSCHEN-LIKE, and PUCHI redundantly control floral meristem identity and organ initiation in Arabidopsis.
WIND1 directly binds the ESR1 promoter and activates tts expression.
Title: WIND1 Promotes Shoot Regeneration through Transcriptional Activation of ENHANCER OF SHOOT REGENERATION1 in Arabidopsis.
Study shows that DRN and DRNL promote cell proliferation, most probably via the G1-S transition.
Title: The AP2-type transcription factors DORNRÖSCHEN and DORNRÖSCHEN-LIKE promote G1/S transition.
These results define new roles for KH-domain containing proteins with ESR1 unlinking jasmonic acid-mediated growth and defense responses.
Title: The Arabidopsis KH-Domain RNA-Binding Protein ESR1 Functions in Components of Jasmonate Signalling, Unlinking Growth Restraint and Resistance to Stress.
Although DRN and DRNL transgenic lines are both activated in surface cells, their promoter activity marks different cell identities.
Title: Live imaging of DORNRÖSCHEN and DORNRÖSCHEN-LIKE promoter activity reveals dynamic changes in cell identity at the microcallus surface of Arabidopsis embryonic suspensions.
ESR1 is expressed both prior to and during shoot formation, whereas ESR2 is expressed only during shoot formation.
Title: Arabidopsis ENHANCER OF SHOOT REGENERATION (ESR)1 and ESR2 regulate in vitro shoot regeneration and their expressions are differentially regulated.
DRN and DRNL act cell-autonomously and are co-expressed in the early globular embryo, whereas expression patterns diverge during later stages of embryogeny
Title: Genetic integration of DORNRÖSCHEN and DORNRÖSCHEN-LIKE reveals hierarchical interactions in auxin signalling and patterning of the Arabidopsis apical embryo.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_101169.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription cis-regulatory region binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cotyledon development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within plant organ morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to cytokinin	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within specification of plant organ axis polarity	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Integrase-type DNA-binding superfamily protein

NP_172758.1

ENHANCER OF SHOOT REGENERATION 1 (ESR1); CONTAINS InterPro DOMAIN/s: DNA-binding, integrase-type (InterPro:IPR016177), Pathogenesis-related transcriptional factor/ERF, DNA-binding (InterPro:IPR001471); BEST Arabidopsis thaliana protein match is: DORNROSCHEN-like (TAIR:AT1G24590.1); Has 5974 Blast hits to 5668 proteins in 251 species: Archae - 0; Bacteria - 2; Metazoa - 4; Fungi - 2; Plants - 5957; Viruses - 0; Other Eukaryotes - 9 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

4429718..4430965

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_101169.3 → NP_172758.1 Integrase-type DNA-binding superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_172758.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8W258, Q9SAD4

UniProtKB/TrEMBL

A0A654EBD3

Conserved Domains (1) summary

smart00380
Location:56 → 114

AP2; DNA-binding domain in plant proteins such as APETALA2 and EREBPs