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    MED32 mediator of RNA polymerase II transcription subunit-like protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837720, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MED32
    Official Full Name
    mediator of RNA polymerase II transcription subunit-like protein
    Primary source
    TAIR:AT1G11760
    Locus tag
    AT1G11760
    See related
    Araport:AT1G11760
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F25C20.9; F25C20_9
    Summary
    Required for expression of CBF-controlled cold-responsive genes. Required for recruitment of the Mediator complex and RNA polymerase II to CBF-controlled cold-responsive genes.
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    Genomic context

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    See MED32 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    2
    Sequence:
    Chromosome: 1; NC_003070.9 (3971986..3973294, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene CLP protease proteolytic subunit 6 Neighboring gene Undecaprenyl pyrophosphate synthetase family protein Neighboring gene Plant self-incompatibility protein S1 family Neighboring gene FAD-binding Berberine family protein Neighboring gene ncRNA Neighboring gene oxidoreductase, 2OG-Fe(II) oxygenase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Redox regulation of the MED28 and MED32 mediator subunits is important for development and senescence. Shaikhali J, et al. Protoplasma, 2016 May. PMID 26195288
    2. Mediator Subunits MED16, MED14, and MED2 Are Required for Activation of ABRE-Dependent Transcription in Arabidopsis. Lee M, et al. Front Plant Sci, 2021. PMID 33777083, Free PMC Article
    3. The Arabidopsis mediator complex subunits MED16, MED14, and MED2 regulate mediator and RNA polymerase II recruitment to CBF-responsive cold-regulated genes. Hemsley PA, et al. Plant Cell, 2014 Jan. PMID 24415770, Free PMC Article
    4. Biochemical and redox characterization of the mediator complex and its associated transcription factor GeBPL, a GLABROUS1 enhancer binding protein. Shaikhali J, et al. Biochem J, 2015 Jun 15. PMID 25877331
    5. Purification of a plant mediator from Arabidopsis thaliana identifies PFT1 as the Med25 subunit. Bäckström S, et al. Mol Cell, 2007 Jun 8. PMID 17560376

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Med32 role in root development and senescence, two processes which are dependent on redox regulation.
      Title: Redox regulation of the MED28 and MED32 mediator subunits is important for development and senescence.
    2. Data suggest that presence of mediator complex subunits MED10a, MED28, and MED32 or changes in redox state affect DNA-binding capacity of GeBPL (GLABROUS1/GL1 enhancer-binding protein-like) at likely GLABROUS1/GL1 promoter.
      Title: Biochemical and redox characterization of the mediator complex and its associated transcription factor GeBPL, a GLABROUS1 enhancer binding protein.
    3. RNA polymerase II recruitment to CBF-responsive cold-regulated genes requires MED16, MED2, and MED14 subunits.
      Title: The Arabidopsis mediator complex subunits MED16, MED14, and MED2 regulate mediator and RNA polymerase II recruitment to CBF-responsive cold-regulated genes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_101048.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables transcription coregulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within abscisic acid-activated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cold acclimation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in leaf senescence IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to hydrogen peroxide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mediator of RNA polymerase II transcription subunit-like protein
    NP_172641.2
    • MED32; Has 41 Blast hits to 40 proteins in 14 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 41; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      3971986..3973294 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101048.4 → NP_172641.2  mediator of RNA polymerase II transcription subunit-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172641.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q84VW5, Q9SAA1
      UniProtKB/TrEMBL
      A0A178WG85, A0A5S9TX42
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q84VW5.1

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