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    PRORP1 proteinaceous RNase P 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817782, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PRORP1
    Official Full Name
    proteinaceous RNase P 1
    Primary source
    TAIR:AT2G32230
    Locus tag
    AT2G32230
    See related
    Araport:AT2G32230
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F22D22.2; F22D22_2; proteinaceous RNase P 1
    Summary
    RNase P able to cleave tRNA-like structures involved in the maturation of plant mitochondrial mRNAs.
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    Genomic context

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    See PRORP1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    7
    Sequence:
    Chromosome: 2; NC_003071.7 (13679529..13682333, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene cysteine-rich/transmembrane domain A-like protein Neighboring gene Ribosomal L27e protein family Neighboring gene uncharacterized protein Neighboring gene early endosome antigen

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pentatricopeptide repeats of protein-only RNase P use a distinct mode to recognize conserved bases and structural elements of pre-tRNA. Teramoto T, et al. Nucleic Acids Res, 2020 Dec 2. PMID 32719843, Free PMC Article
    2. Determination of protein-only RNase P interactome in Arabidopsis mitochondria and chloroplasts identifies a complex between PRORP1 and another NYN domain nuclease. Bouchoucha A, et al. Plant J, 2019 Nov. PMID 31319441
    3. Cleavage of Model Substrates by Arabidopsis thaliana PRORP1 Reveals New Insights into Its Substrate Requirements. Mao G, et al. PLoS One, 2016. PMID 27494328, Free PMC Article
    4. Multiple RNA processing defects and impaired chloroplast function in plants deficient in the organellar protein-only RNase P enzyme. Zhou W, et al. PLoS One, 2015. PMID 25793367, Free PMC Article
    5. tRNA processing by protein-only versus RNA-based RNase P: kinetic analysis reveals mechanistic differences. Pavlova LV, et al. Chembiochem, 2012 Oct 15. PMID 22976545

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pentatricopeptide repeats of protein-only RNase P use a distinct mode to recognize conserved bases and structural elements of pre-tRNA.
      Title: Pentatricopeptide repeats of protein-only RNase P use a distinct mode to recognize conserved bases and structural elements of pre-tRNA.
    2. The results revealed the existence of an RNA maturation complex in Arabidopsis mitochondria and suggested that PRORP proteins cooperated with other gene expression factors for RNA maturation in vivo.
      Title: Determination of protein-only RNase P interactome in Arabidopsis mitochondria and chloroplasts identifies a complex between PRORP1 and another NYN domain nuclease.
    3. The comparative biology of Escherichia coli RNase P and Arabidopsis thaliana PRORP isozymes has been reported.
      Title: Protein-only RNase P function in Escherichia coli: viability, processing defects and differences between PRORP isoenzymes.
    4. PRORP1 protein substrate recognition requirements for tRNA
      Title: Cleavage of Model Substrates by Arabidopsis thaliana PRORP1 Reveals New Insights into Its Substrate Requirements.
    5. The study presents the first kinetic analysis of PRORP1, PRORP2 and PRORP3.
      Title: tRNA processing by protein-only versus RNA-based RNase P: kinetic analysis reveals mechanistic differences.
    6. In Arabidopsis mitochondria and plastids, a single protein called 'proteinaceous RNase P' (PRORP1) can perform the endonucleolytic maturation of tRNA precursors that defines RNase P activity. [PRORP1]
      Title: A single Arabidopsis organellar protein has RNase P activity.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_179855.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ribonuclease P activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribonuclease P activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within tRNA 5'-leader removal IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within tRNA processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    proteinaceous RNase P 1
    NP_850186.1
    • proteinaceous RNase P 1 (PRORP1); CONTAINS InterPro DOMAIN/s: Multi antimicrobial extrusion protein MatE (InterPro:IPR002528), Pentatricopeptide repeat (InterPro:IPR002885); BEST Arabidopsis thaliana protein match is: proteinaceous RNase P 3 (TAIR:AT4G21900.1); Has 2190 Blast hits to 1686 proteins in 140 species: Archae - 0; Bacteria - 0; Metazoa - 111; Fungi - 4; Plants - 1945; Viruses - 0; Other Eukaryotes - 130 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      13679529..13682333 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001336377.1 → NP_001324632.1  proteinaceous RNase P 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q66GI4, Q8RWW5, Q9SKX7
      UniProtKB/TrEMBL
      A0A178VZD1, A0A5S9X370
      Conserved Domains (3) summary
      sd00004
      Location:134 → 170
      PPR; PPR repeat [structural motif]
      pfam16953
      Location:338 → 565
      PRORP; Protein-only RNase P
      pfam17177
      Location:87 → 296
      PPR_long; Pentacotripeptide-repeat region of PRORP

    2. NM_179855.3 → NP_850186.1  proteinaceous RNase P 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850186.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q66GI4, Q8RWW5, Q9SKX7
      UniProtKB/TrEMBL
      A0A178VZD1, A0A5S9X370
      Conserved Domains (3) summary
      sd00004
      Location:134 → 170
      PPR; PPR repeat [structural motif]
      pfam16953
      Location:338 → 565
      PRORP; Protein-only RNase P
      pfam17177
      Location:87 → 296
      PPR_long; Pentacotripeptide-repeat region of PRORP
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q66GI4.1

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