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    CDC5 cell division cycle 5 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837506, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CDC5
    Official Full Name
    cell division cycle 5
    Primary source
    TAIR:AT1G09770
    Locus tag
    AT1G09770
    See related
    Araport:AT1G09770
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA CELL DIVISION CYCLE 5; ARABIDOPSIS THALIANA MYB DOMAIN CELL DIVISION CYCLE 5; ATCDC5; ATMYBCDC5; cell division cycle 5; F21M12.15; F21M12_15
    Summary
    Member of MYB3R- and R2R3- type MYB- encoding genes. Essential for plant innate immunity. Interacts with MOS4 and PRL1.
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    Genomic context

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    See CDC5 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    4
    Sequence:
    Chromosome: 1; NC_003070.9 (3161832..3165616)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Cysteine proteinases superfamily protein Neighboring gene Adenine nucleotide alpha hydrolases-like superfamily protein Neighboring gene Eukaryotic aspartyl protease family protein Neighboring gene U2 small nuclear ribonucleoprotein A Neighboring gene Phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent Neighboring gene COBRA-like protein 6 precursor Neighboring gene Cox19 family protein (CHCH motif)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Virus induced gene silencing of AtCDC5 results in accelerated cell death in Arabidopsis leaves. Lin Z, et al. Plant Physiol Biochem, 2007 Jan. PMID 17298883
    2. Two distinct nucleic acid binding surfaces of Cdc5 regulate development. Wang C, et al. Biochem J, 2019 Nov 15. PMID 31652438, Free PMC Article
    3. AtCDC5 regulates the G2 to M transition of the cell cycle and is critical for the function of Arabidopsis shoot apical meristem. Lin Z, et al. Cell Res, 2007 Sep. PMID 17768399
    4. CDC5, a DNA binding protein, positively regulates posttranscriptional processing and/or transcription of primary microRNA transcripts. Zhang S, et al. Proc Natl Acad Sci U S A, 2013 Oct 22. PMID 24101471, Free PMC Article
    5. Regulation of plant innate immunity by three proteins in a complex conserved across the plant and animal kingdoms. Palma K, et al. Genes Dev, 2007 Jun 15. PMID 17575050, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mutation in R31, K42, and K100 in AtCDC5 greatly impair the functions of AtCDC5, resulting in pleiotropic development defects and reduced levels of primary microRNA transcripts.
      Title: Two distinct nucleic acid binding surfaces of Cdc5 regulate development.
    2. Results suggest that CDC5 may have dual roles in miRNA biogenesis: functioning as a positive transcription factor of MIR and/or acting as a component of the DICER-LIKE1 complex to enhance primary miRNA processing.
      Title: CDC5, a DNA binding protein, positively regulates posttranscriptional processing and/or transcription of primary microRNA transcripts.
    3. These results suggest that AtCDC5 is essential for the G2/M phase transition and may regulate the function of SAM by controlling the expression of STM and WUS.
      Title: AtCDC5 regulates the G2 to M transition of the cell cycle and is critical for the function of Arabidopsis shoot apical meristem.
    4. Silencing of AtCDC5 in wild-type plants all induces cell death.
      Title: Virus induced gene silencing of AtCDC5 results in accelerated cell death in Arabidopsis leaves.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_100849.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Prp19 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    cell division cycle 5
    NP_172448.1
    • cell division cycle 5 (CDC5); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: defense response signaling pathway, resistance gene-independent, defense response signaling pathway, resistance gene-dependent, defense response to bacterium, defense response to fungus, regulation of transcription; LOCATED IN: chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Protein of unknown function DUF3351 (InterPro:IPR021786), SANT, DNA-binding (InterPro:IPR001005), Myb, DNA-binding (InterPro:IPR014778), Homeodomain-like (InterPro:IPR009057), Myb transcription factor (InterPro:IPR015495), Homeodomain-related (InterPro:IPR012287), HTH transcriptional regulator, Myb-type, DNA-binding (InterPro:IPR017930); BEST Arabidopsis thaliana protein match is: myb domain protein 3r-4 (TAIR:AT5G11510.1); Has 13137 Blast hits to 10813 proteins in 768 species: Archae - 14; Bacteria - 356; Metazoa - 3570; Fungi - 914; Plants - 4936; Viruses - 8; Other Eukaryotes - 3339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      3161832..3165616
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100849.3 → NP_172448.1  cell division cycle 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172448.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DFT0, O04498, P92948, Q6R0C5
      UniProtKB/TrEMBL
      A0A178WIY6, A0A5S9TI80
      Conserved Domains (3) summary
      PTZ00121
      Location:675 → 834
      PTZ00121; MAEBL; Provisional
      COG5147
      Location:1 → 231
      REB1; Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]
      pfam11831
      Location:407 → 656
      Myb_Cef; pre-mRNA splicing factor component
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P92948.2

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