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    COP13 Proteasome component (PCI) domain protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831275, updated on 18-Sep-2024

    Summary

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    Official Symbol
    COP13
    Official Full Name
    Proteasome component (PCI) domain protein
    Primary source
    TAIR:AT5G14250
    Locus tag
    AT5G14250
    See related
    Araport:AT5G14250
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CONSTITUTIVE PHOTOMORPHOGENIC 13; COP9 SIGNALOSOME SUBUNIT 3; CSN3; F18O22.40; F18O22_40; FUS11; FUSCA 11
    Summary
    Encodes subunit 3 of the COP9 signalosome.
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    Genomic context

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    See COP13 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    11
    Sequence:
    Chromosome: 5; NC_003076.8 (4597868..4600835)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ankyrin Neighboring gene ncRNA Neighboring gene Thioredoxin superfamily protein Neighboring gene Rubisco methyltransferase family protein Neighboring gene uncharacterized protein Neighboring gene bromodomain and extraterminal domain protein 9

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A role of Arabidopsis COP9 signalosome in multifaceted developmental processes revealed by the characterization of its subunit 3. Peng Z, et al. Development, 2001 Nov. PMID 11684663
    2. TSA1 interacts with CSN1/CSN and may be functionally involved in Arabidopsis seedling development in darkness. Li W, et al. J Genet Genomics, 2011 Nov 20. PMID 22133685
    3. The eta7/csn3-3 auxin response mutant of Arabidopsis defines a novel function for the CSN3 subunit of the COP9 signalosome. Huang H, et al. PLoS One, 2013. PMID 23762492, Free PMC Article
    4. An alternative tandem affinity purification strategy applied to Arabidopsis protein complex isolation. Rubio V, et al. Plant J, 2005 Mar. PMID 15703063
    5. Molecular characterization of subunit 6 of the COP9 signalosome and its role in multifaceted developmental processes in Arabidopsis. Peng Z, et al. Plant Cell, 2001 Nov. PMID 11701877, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CSN3 functions in a distinct protein complex that is required for proper auxin signaling.
      Title: The eta7/csn3-3 auxin response mutant of Arabidopsis defines a novel function for the CSN3 subunit of the COP9 signalosome.
    2. Data suggest that Arabidopsis csn mutants undergo DNA damage, which might be the cause of the delay in G2 cell cycle progression.
      Title: The Arabidopsis COP9 signalosome is essential for G2 phase progression and genomic stability.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001036804.1
    NM_121429.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within photomorphogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein deneddylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of COP9 signalosome TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Proteasome component (PCI) domain protein
    NP_001031881.1
    • CONSTITUTIVE PHOTOMORPHOGENIC 13 (COP13); CONTAINS InterPro DOMAIN/s: Proteasome component (PCI) domain (InterPro:IPR000717); Has 402 Blast hits to 401 proteins in 151 species: Archae - 0; Bacteria - 0; Metazoa - 218; Fungi - 81; Plants - 54; Viruses - 0; Other Eukaryotes - 49 (source: NCBI BLink).
    NP_568296.1
    • CONSTITUTIVE PHOTOMORPHOGENIC 13 (COP13); CONTAINS InterPro DOMAIN/s: Proteasome component (PCI) domain (InterPro:IPR000717), Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      4597868..4600835
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121429.5 → NP_568296.1  Proteasome component (PCI) domain protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568296.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8W575, Q93VY1, Q9LYA4
      UniProtKB/TrEMBL
      A0A178UB34, A0A5S9Y4C1
      Conserved Domains (1) summary
      smart00088
      Location:294 → 381
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15

    2. NM_001036804.1 → NP_001031881.1  Proteasome component (PCI) domain protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031881.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4K5I3
      Conserved Domains (1) summary
      cl02111
      Location:259 → 343
      PCI; PCI domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8W575.2

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