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    HMA1 heavy metal atpase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829881, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HMA1
    Official Full Name
    heavy metal atpase 1
    Primary source
    TAIR:AT4G37270
    Locus tag
    AT4G37270
    See related
    Araport:AT4G37270
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AP22.4; AP22_4; ARABIDOPSIS THALIANA HEAVY METAL ATPASE 1; ATHMA1; heavy metal atpase 1
    Summary
    Encodes a P1B-type ATPases that is localized to the chloroplast envelope and is involved in the transport of Cu into chloroplasts. It is essential for growth under high light conditions.
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    Genomic context

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    See HMA1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    13
    Sequence:
    Chromosome: 4; NC_003075.7 (17541771..17546546, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene myb domain protein 73 Neighboring gene MRG family protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AtHMA1 contributes to the detoxification of excess Zn(II) in Arabidopsis. Kim YY, et al. Plant J, 2009 Jun. PMID 19207208
    2. A T-DNA insertion mutant of AtHMA1 gene encoding a Cu transporting ATPase in Arabidopsis thaliana has a defect in the water-water cycle of photosynthesis. Higuchi M, et al. J Photochem Photobiol B, 2009 Mar 3. PMID 19144536
    3. AtHMA1 is a thapsigargin-sensitive Ca2+/heavy metal pump. Moreno I, et al. J Biol Chem, 2008 Apr 11. PMID 18252706
    4. HMA1, a new Cu-ATPase of the chloroplast envelope, is essential for growth under adverse light conditions. Seigneurin-Berny D, et al. J Biol Chem, 2006 Feb 3. PMID 16282320
    5. HMA1 and PAA1, two chloroplast-envelope PIB-ATPases, play distinct roles in chloroplast copper homeostasis. Boutigny S, et al. J Exp Bot, 2014 Apr. PMID 24510941

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HMA1 and PAA1 behave as distinct pathways for copper import and targeting to the chloroplast.
      Title: HMA1 and PAA1, two chloroplast-envelope PIB-ATPases, play distinct roles in chloroplast copper homeostasis.
    2. HMA1 knock-outs exhibited greater sensitivity to excess Zn(II), and accumulated more Zn in their shoots.
      Title: AtHMA1 contributes to the detoxification of excess Zn(II) in Arabidopsis.
    3. the water-water cycle is impaired in the T-DNA insertion mutant of AtHMA1 gene in chloroplasts
      Title: A T-DNA insertion mutant of AtHMA1 gene encoding a Cu transporting ATPase in Arabidopsis thaliana has a defect in the water-water cycle of photosynthesis.
    4. that AtHMA1 functions as a Ca(2+)/heavy metal pump. This protein is the first described plant P-type pump specifically inhibited by thapsigargin.
      Title: AtHMA1 is a thapsigargin-sensitive Ca2+/heavy metal pump.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_119890.7

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables P-type cadmium transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type cadmium transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables P-type calcium transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables P-type divalent copper transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables P-type zinc transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within calcium ion transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in detoxification of zinc ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular copper ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to light intensity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to toxic substance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    heavy metal atpase 1
    NP_195444.1
    • heavy metal atpase 1 (HMA1); FUNCTIONS IN: copper-exporting ATPase activity, ATPase activity, calcium-transporting ATPase activity, zinc transporting ATPase activity, cadmium-transporting ATPase activity; INVOLVED IN: cellular copper ion homeostasis, calcium ion transport, response to toxin, zinc ion homeostasis, response to light intensity; LOCATED IN: chloroplast, chloroplast envelope; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Haloacid dehalogenase-like hydrolase (InterPro:IPR005834), ATPase, P-type, heavy metal translocating (InterPro:IPR006416), ATPase, P-type, ATPase-associated domain (InterPro:IPR008250), ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter (InterPro:IPR001757), ATPase, P-type, heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating (InterPro:IPR006404), ATPase, P-type phosphorylation site (InterPro:IPR018303); BEST Arabidopsis thaliana protein match is: heavy metal atpase 2 (TAIR:AT4G30110.1); Has 36740 Blast hits to 31592 proteins in 3081 species: Archae - 714; Bacteria - 24289; Metazoa - 3807; Fungi - 1794; Plants - 1612; Viruses - 8; Other Eukaryotes - 4516 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      17541771..17546546 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119890.7 → NP_195444.1  heavy metal atpase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195444.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q5JZZ1, Q9M3H5, Q9SW66
      UniProtKB/TrEMBL
      A0A178UYF8
      Conserved Domains (3) summary
      COG4087
      Location:613 → 715
      COG4087; Soluble P-type ATPase [General function prediction only]
      TIGR01512
      Location:185 → 785
      ATPase-IB2_Cd; heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase
      pfam00122
      Location:207 → 442
      E1-E2_ATPase; E1-E2 ATPase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M3H5.2

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