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    ERA1 Prenyltransferase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834026, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ERA1
    Official Full Name
    Prenyltransferase family protein
    Primary source
    TAIR:AT5G40280
    Locus tag
    AT5G40280
    See related
    Araport:AT5G40280
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA FARNESYL TRANSFERASE BETA SUBUNIT; ATFTB; ENHANCED RESPONSE TO ABA 1; FARNESYL TRANSFERASE BETA SUBUNIT; MSN9.180; MSN9_180; WIG; WIGGUM
    Summary
    encodes a beta subunit of farnesyl-trans-transferase, which is involved in meristem organization and ABA-mediated signal transduction pathway. Mutant phenotypes have been observed in meristem organization, and response to abscisic acid and drought.
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    Genomic context

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    See ERA1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    14
    Sequence:
    Chromosome: 5; NC_003076.8 (16101343..16104962)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene HD domain-containing metal-dependent phosphohydrolase family protein Neighboring gene ncRNA Neighboring gene HD domain-containing metal-dependent phosphohydrolase family protein Neighboring gene Uncharacterized protein family (UPF0497)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Role of ENHANCED RESPONSES TO ABA1 (ERA1) in Arabidopsis Stomatal Responses Is Beyond ABA Signaling. Jalakas P, et al. Plant Physiol, 2017 Jun. PMID 28330935, Free PMC Article
    2. The Arabidopsis heat-intolerant 5 (hit5)/enhanced response to aba 1 (era1) mutant reveals the crucial role of protein farnesylation in plant responses to heat stress. Wu JR, et al. New Phytol, 2017 Feb. PMID 27673599
    3. A novel role for protein farnesylation in plant innate immunity. Goritschnig S, et al. Plant Physiol, 2008 Sep. PMID 18599656, Free PMC Article
    4. Functional requirement of plant farnesyltransferase during development in Arabidopsis. Yalovsky S, et al. Plant Cell, 2000 Aug. PMID 10948248, Free PMC Article
    5. Cloning of the Arabidopsis WIGGUM gene identifies a role for farnesylation in meristem development. Ziegelhoffer EC, et al. Proc Natl Acad Sci U S A, 2000 Jun 20. PMID 10840062, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A role for ERA1 in blue light-induced stomatal opening, pathogen immunity and disease resistance
      Title: The Role of ENHANCED RESPONSES TO ABA1 (ERA1) in Arabidopsis Stomatal Responses Is Beyond ABA Signaling.
    2. Map-based cloning revealed that HIT5 encodes the beta-subunit of the protein farnesyltransferase.
      Title: The Arabidopsis heat-intolerant 5 (hit5)/enhanced response to aba 1 (era1) mutant reveals the crucial role of protein farnesylation in plant responses to heat stress.
    3. farnesyltransferase in plant-pathogen interactions, mutants display enhanced susceptibility to virulent bacterial and oomycete pathogens
      Title: A novel role for protein farnesylation in plant innate immunity.
    4. Used to demonstrate the feasibility of bimolecular fluorescence complementation in plants.
      Title: Detection of protein-protein interactions in plants using bimolecular fluorescence complementation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001344319.1
    NM_123392.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables farnesyltranstransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein farnesyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein farnesyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein farnesyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cutin-based cuticle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of abscisic acid-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of abscisic acid-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein farnesylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within protein prenylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of meristem structural organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to abscisic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to fungus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to water deprivation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within stomatal opening IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of protein farnesyltransferase complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of protein farnesyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Prenyltransferase family protein
    NP_198844.1
    • ENHANCED RESPONSE TO ABA 1 (ERA1); CONTAINS InterPro DOMAIN/s: Terpenoid cylases/protein prenyltransferase alpha-alpha toroid (InterPro:IPR008930), Prenyltransferase/squalene oxidase (InterPro:IPR001330); BEST Arabidopsis thaliana protein match is: RAB geranylgeranyl transferase beta subunit 2 (TAIR:AT3G12070.2); Has 2257 Blast hits to 1610 proteins in 263 species: Archae - 4; Bacteria - 30; Metazoa - 707; Fungi - 630; Plants - 303; Viruses - 4; Other Eukaryotes - 579 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      16101343..16104962
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_123392.2 → NP_198844.1  Prenyltransferase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_198844.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4VCL6, Q38916, Q38920, Q8LPK8, Q9LLE9
      UniProtKB/TrEMBL
      A0A5S9Y9M8, A0A654G6R0
      Conserved Domains (1) summary
      PLN02710
      Location:42 → 482
      PLN02710; farnesyltranstransferase subunit beta

    2. NM_001344319.1 → NP_001331518.1  Prenyltransferase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BE65, A0A5S9Y9M8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q38920.3

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