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    BIP2 Heat shock protein 70 (Hsp 70) family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834207, updated on 18-Sep-2024

    Summary

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    Official Symbol
    BIP2
    Official Full Name
    Heat shock protein 70 (Hsp 70) family protein
    Primary source
    TAIR:AT5G42020
    Locus tag
    AT5G42020
    See related
    Araport:AT5G42020
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    BIP; luminal binding protein; MJC20.12; MJC20_12
    Summary
    Luminal binding protein (BiP2) involved in polar nuclei fusion during proliferation of endosperm nuclei.
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    Genomic context

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    See BIP2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    6
    Sequence:
    Chromosome: 5; NC_003076.8 (16807342..16810693, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ORMDL family protein Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene ABL interactor-like protein 4 Neighboring gene regulatory particle non-ATPase 12B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Induction of BiP by sugar independent of a cis-element for the unfolded protein response in Arabidopsis thaliana. Tajima H, et al. Biochem Biophys Res Commun, 2006 Aug 4. PMID 16781668
    2. Alteration of the bZIP60/IRE1 pathway affects plant response to ER stress in Arabidopsis thaliana. Humbert S, et al. PLoS One, 2012. PMID 22701744, Free PMC Article
    3. BiP-mediated polar nuclei fusion is essential for the regulation of endosperm nuclei proliferation in Arabidopsis thaliana. Maruyama D, et al. Proc Natl Acad Sci U S A, 2010 Jan 26. PMID 20080634, Free PMC Article
    4. AtBAG7, an Arabidopsis Bcl-2-associated athanogene, resides in the endoplasmic reticulum and is involved in the unfolded protein response. Williams B, et al. Proc Natl Acad Sci U S A, 2010 Mar 30. PMID 20231441, Free PMC Article
    5. Isolation and responses to stress of a gene that encodes a luminal binding protein in Arabidopsis thaliana. Koizumi N. Plant Cell Physiol, 1996 Sep. PMID 8888624

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. BIP3 supports the early stages of female gametophyte development, but not polar nuclear fusion, in the absence of BiP1 and BiP2.
      Title: BiP3 supports the early stages of female gametogenesis in the absence of BiP1 and BiP2 in Arabidopsis thaliana.
    2. the bip1 bip2 bip3 triple mutation is lethal in pollen.
      Title: Multiple BiP genes of Arabidopsis thaliana are required for male gametogenesis and pollen competitiveness.
    3. Data show detectable amounts of YFP-bZIP28 escaped from endoplasmic reticulum (ER) to nuclei under unstressed conditions in the bip1/bip1 bip2/+ and in the bip1/+ bip2/bip2 and bip3 mutant lines.
      Title: BINDING PROTEIN is a master regulator of the endoplasmic reticulum stress sensor/transducer bZIP28 in Arabidopsis.
    4. The endoplasmic reticulum-resident chaperone BiP accumulates differentially depending on the level of activation of the bZIP60/IRE1 pathway.
      Title: Alteration of the bZIP60/IRE1 pathway affects plant response to ER stress in Arabidopsis thaliana.
    5. bip1 bip2 double mutation causes defects in the fusion of polar nuclei during female gametophyte development.
      Title: BiP-mediated polar nuclei fusion is essential for the regulation of endosperm nuclei proliferation in Arabidopsis thaliana.
    6. BiP is induced by sugar independent of the cis-element responsible for the unfolded protein response
      Title: Induction of BiP by sugar independent of a cis-element for the unfolded protein response in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001344430.1
    NM_123567.3
    NM_180788.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within polar nucleus fusion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within protein folding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to endoplasmic reticulum stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to heat IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    NOT located_in Golgi apparatus RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum TAS
    Traceable Author Statement
    more info
    		  
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in plant-type cell wall HDA PubMed 
    located_in plant-type vacuole HDA PubMed 
    located_in plasmodesma HDA PubMed 
    located_in plastid HDA PubMed 
    located_in secretory vesicle HDA PubMed 

    General protein information

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    Preferred Names
    Heat shock protein 70 (Hsp 70) family protein
    NP_199017.2
    • luminal binding protein (BIP); FUNCTIONS IN: ATP binding; INVOLVED IN: protein folding, response to cadmium ion, response to heat, polar nucleus fusion, response to endoplasmic reticulum stress; LOCATED IN: in 8 components; EXPRESSED IN: 7 plant structures; EXPRESSED DURING: seedling growth, seed development stages; CONTAINS InterPro DOMAIN/s: Heat shock protein 70, conserved site (InterPro:IPR018181), Heat shock protein Hsp70 (InterPro:IPR001023), Heat shock protein 70 (InterPro:IPR013126); BEST Arabidopsis thaliana protein match is: heat shock protein 70 (Hsp 70) family protein (TAIR:AT5G28540.1); Has 34912 Blast hits to 34423 proteins in 4667 species: Archae - 159; Bacteria - 17150; Metazoa - 3676; Fungi - 1797; Plants - 1301; Viruses - 340; Other Eukaryotes - 10489 (source: NCBI BLink).
    NP_851119.1
    • BIP2; FUNCTIONS IN: ATP binding; INVOLVED IN: protein folding, response to cadmium ion, response to heat, polar nucleus fusion, response to endoplasmic reticulum stress; LOCATED IN: in 8 components; EXPRESSED IN: 8 plant structures; EXPRESSED DURING: seedling growth, seed development stages; CONTAINS InterPro DOMAIN/s: Heat shock protein 70, conserved site (InterPro:IPR018181), Heat shock protein Hsp70 (InterPro:IPR001023), Heat shock protein 70 (InterPro:IPR013126); BEST Arabidopsis thaliana protein match is: heat shock protein 70 (Hsp 70) family protein (TAIR:AT5G28540.1); Has 36681 Blast hits to 36078 proteins in 4871 species: Archae - 169; Bacteria - 17752; Metazoa - 3980; Fungi - 1822; Plants - 1284; Viruses - 342; Other Eukaryotes - 11332 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      16807342..16810693 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_180788.3 → NP_851119.1  Heat shock protein 70 (Hsp 70) family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851119.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q39042, Q39043
      UniProtKB/TrEMBL
      A0A178UG43, A0A5S9YAG6, A0A7G2FAT4
      Conserved Domains (1) summary
      PTZ00009
      Location:35 → 654
      PTZ00009; heat shock 70 kDa protein; Provisional

    2. NM_001344430.1 → NP_001331824.1  Heat shock protein 70 (Hsp 70) family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BF32, A0A7G2FAT4

    3. NM_123567.3 → NP_199017.2  Heat shock protein 70 (Hsp 70) family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199017.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2FAT4, F4K007
      Conserved Domains (2) summary
      cd10241
      Location:35 → 409
      HSPA5-like_NBD; Nucleotide-binding domain of human HSPA5 and similar proteins
      PTZ00009
      Location:35 → 599
      PTZ00009; heat shock 70 kDa protein; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q39043.2

    Gene LinkOut

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