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    HOL2 S-adenosyl-L-methionine-dependent methyltransferases superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818996, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HOL2
    Official Full Name
    S-adenosyl-L-methionine-dependent methyltransferases superfamily protein
    Primary source
    TAIR:AT2G43920
    Locus tag
    AT2G43920
    See related
    Araport:AT2G43920
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATHOL2; F6E13.5; HARMLESS TO OZONE LAYER 2
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    Genomic context

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    See HOL2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    8
    Sequence:
    Chromosome: 2; NC_003071.7 (18189004..18191348, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene HARMLESS TO OZONE LAYER 1 Neighboring gene miscRNA Neighboring gene Protein kinase superfamily protein Neighboring gene miscRNA Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis HARMLESS TO OZONE LAYER protein methylates a glucosinolate breakdown product and functions in resistance to Pseudomonas syringae pv. maculicola. Nagatoshi Y, et al. J Biol Chem, 2009 Jul 17. PMID 19419967, Free PMC Article
    2. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article
    3. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    NM_001125049.1
    NM_001161106.2
    NM_001337066.1
    NM_001337067.1
    NM_001337068.1
    NM_129954.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables thiol S-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    S-adenosyl-L-methionine-dependent methyltransferases superfamily protein
    NP_001118521.1
    • HARMLESS TO OZONE LAYER 2 (HOL2); FUNCTIONS IN: methyltransferase activity, thiopurine S-methyltransferase activity; INVOLVED IN: metabolic process; LOCATED IN: cytoplasm; CONTAINS InterPro DOMAIN/s: Thiopurine S-methyltransferase (InterPro:IPR008854); BEST Arabidopsis thaliana protein match is: HARMLESS TO OZONE LAYER 1 (TAIR:AT2G43910.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_001318421.1
    • HARMLESS TO OZONE LAYER 2 (HOL2); FUNCTIONS IN: methyltransferase activity, thiopurine S-methyltransferase activity; INVOLVED IN: metabolic process; LOCATED IN: cytoplasm; CONTAINS InterPro DOMAIN/s: Thiopurine S-methyltransferase (InterPro:IPR008854); BEST Arabidopsis thaliana protein match is: HARMLESS TO OZONE LAYER 1 (TAIR:AT2G43910.1); Has 463 Blast hits to 462 proteins in 177 species: Archae - 0; Bacteria - 223; Metazoa - 0; Fungi - 76; Plants - 70; Viruses - 0; Other Eukaryotes - 94 (source: NCBI BLink).
    NP_181920.1
    • HARMLESS TO OZONE LAYER 2 (HOL2); FUNCTIONS IN: methyltransferase activity, thiopurine S-methyltransferase activity; INVOLVED IN: metabolic process; LOCATED IN: cytoplasm; CONTAINS InterPro DOMAIN/s: Thiopurine S-methyltransferase (InterPro:IPR008854); BEST Arabidopsis thaliana protein match is: HARMLESS TO OZONE LAYER 1 (TAIR:AT2G43910.1); Has 1105 Blast hits to 1103 proteins in 422 species: Archae - 14; Bacteria - 767; Metazoa - 4; Fungi - 106; Plants - 74; Viruses - 0; Other Eukaryotes - 140 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      18189004..18191348 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129954.4 → NP_181920.1  S-adenosyl-L-methionine-dependent methyltransferases superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_181920.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3H663, O80562
      UniProtKB/TrEMBL
      A0A178VP97, A0A5S9X727
      Conserved Domains (1) summary
      pfam05724
      Location:31 → 217
      TPMT; Thiopurine S-methyltransferase (TPMT)

    2. NM_001125049.1 → NP_001118521.1  S-adenosyl-L-methionine-dependent methyltransferases superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001118521.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O80562
      Conserved Domains (1) summary
      pfam05724
      Location:31 → 185
      TPMT; Thiopurine S-methyltransferase (TPMT)

    3. NM_001337066.1 → NP_001318421.1  S-adenosyl-L-methionine-dependent methyltransferases superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VP08

    4. NM_001337067.1 → NP_001325382.1  S-adenosyl-L-methionine-dependent methyltransferases superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VP08

    5. NM_001161106.2 → NP_001154578.1  S-adenosyl-L-methionine-dependent methyltransferases superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001154578.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VP08
      Conserved Domains (1) summary
      cl17173
      Location:1 → 142
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    6. NM_001337068.1 → NP_001325381.1  S-adenosyl-L-methionine-dependent methyltransferases superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VP08
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O80562.1

    Gene LinkOut

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