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    HPT1 homogentisate phytyltransferase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816412, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HPT1
    Official Full Name
    homogentisate phytyltransferase 1
    Primary source
    TAIR:AT2G18950
    Locus tag
    AT2G18950
    See related
    Araport:AT2G18950
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATHPT; F19F24.15; F19F24_15; HOMOGENTISATE PHYTYLTRANSFERASE; homogentisate phytyltransferase 1; TOCOPHEROL PHYTYLTRANSFERASE; TOCOPHEROL POLYPRENYLTRANSFERASE; TPT1; VITAMIN E 2; VTE2
    Summary
    Encodes homogentisate phytyltransferase involved in tocopherol biosynthesis. Has impact on seed longevity and plays a role in the adaptation to low temperature stress, notably phloem loading.
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    Genomic context

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    See HPT1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    13
    Sequence:
    Chromosome: 2; NC_003071.7 (8207199..8210513)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene H[+]-ATPase 1 Neighboring gene transcription factor/transcription regulator Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Vitamin E is essential for seed longevity and for preventing lipid peroxidation during germination. Sattler SE, et al. Plant Cell, 2004 Jun. PMID 15155886, Free PMC Article
    2. Homogentisate phytyltransferase activity is limiting for tocopherol biosynthesis in Arabidopsis. Collakova E, et al. Plant Physiol, 2003 Feb. PMID 12586887, Free PMC Article
    3. Isolation and functional analysis of homogentisate phytyltransferase from Synechocystis sp. PCC 6803 and Arabidopsis. Collakova E, et al. Plant Physiol, 2001 Nov. PMID 11706191, Free PMC Article
    4. Nonenzymatic lipid peroxidation reprograms gene expression and activates defense markers in Arabidopsis tocopherol-deficient mutants. Sattler SE, et al. Plant Cell, 2006 Dec. PMID 17194769, Free PMC Article
    5. Tocopherols play a crucial role in low-temperature adaptation and Phloem loading in Arabidopsis. Maeda H, et al. Plant Cell, 2006 Oct. PMID 17012603, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    NM_001335615.1
    NM_179653.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables homogentisate phytyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables homogentisate phytyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables prenyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables prenyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell wall organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within fat-soluble vitamin biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within phloem sucrose loading IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of defense response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to temperature stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within unsaturated fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vitamin E biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within vitamin E biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within vitamin E biosynthetic process TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    homogentisate phytyltransferase 1
    NP_849984.1
    • homogentisate phytyltransferase 1 (HPT1); CONTAINS InterPro DOMAIN/s: UbiA prenyltransferase (InterPro:IPR000537); BEST Arabidopsis thaliana protein match is: homogentisate prenyltransferase (TAIR:AT3G11945.1); Has 1047 Blast hits to 1044 proteins in 315 species: Archae - 194; Bacteria - 477; Metazoa - 7; Fungi - 6; Plants - 190; Viruses - 0; Other Eukaryotes - 173 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      8207199..8210513
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_179653.4 → NP_849984.1  homogentisate phytyltransferase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849984.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O64625, Q8VWJ1
      UniProtKB/TrEMBL
      A0A178VWH1, A0A654EU20
      Conserved Domains (1) summary
      PLN02878
      Location:114 → 393
      PLN02878; homogentisate phytyltransferase

    2. NM_001335615.1 → NP_001325303.1  homogentisate phytyltransferase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B2S8, A0A654EU20
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VWJ1.1

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