FVE Transducin family protein / WD-40 repeat family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: FVE
Official Full Name: Transducin family protein / WD-40 repeat family protein
Primary source: TAIR:AT2G19520
Locus tag: AT2G19520
See related: Araport:AT2G19520
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ACG1; ATMSI4; F3P11.12; F3P11_12; MSI4; MULTICOPY SUPPRESSOR OF IRA1 4; NFC04; NFC4; NUCLEOSOME/CHROMATIN ASSEMBLY FACTOR GROUP C; WD-40 REPEAT PROTEIN MSI4
Summary: Controls flowering.
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Genomic context

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See FVE in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 15

Sequence:: Chromosome: 2; NC_003071.7 (8455756..8459642)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MSI4/FVE is required for accumulation of 24-nt siRNAs and DNA methylation at a subset of target regions of RNA-directed DNA methylation.
Title: MSI4/FVE is required for accumulation of 24-nt siRNAs and DNA methylation at a subset of target regions of RNA-directed DNA methylation.
FVE promotes RNA-directed DNA methylation by facilitating the association of RNA polymerase V with chromatin.
Title: FVE promotes RNA-directed DNA methylation by facilitating the association of RNA polymerase V with chromatin.
Dehydroabietinal promotes flowering time and plant defense in Arabidopsis via the autonomous pathway genes FLOWERING LOCUS D, FVE, and RELATIVE OF EARLY FLOWERING 6.
Title: Dehydroabietinal promotes flowering time and plant defense in Arabidopsis via the autonomous pathway genes FLOWERING LOCUS D, FVE, and RELATIVE OF EARLY FLOWERING 6.
We also demonstrate that PTM, a PHD transcription factor involved in chloroplast retrograde signaling, perceives such a signal and mediates transcriptional repression of FLC through recruitment of FVE, a component of the histone deacetylase complex.
Title: Chloroplast retrograde signal regulates flowering.
Data propose these novel ATMSI4-associated proteins help form nucleoprotein complexes that determine pleiotropic functional properties of AtMSI4/FVE/ACG1 involving plant development
Title: Arabidopsis thaliana MSI4/FVE associates with members of a novel family of plant specific PWWP/RRM domain proteins.
FVE is essential for the HOS1-mediated activation of FLC transcription.
Title: The cold signaling attenuator HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENE1 activates FLOWERING LOCUS C transcription via chromatin remodeling under short-term cold stress in Arabidopsis.
Two phospho-beta-galactosidase, LacG1 and LacG2, are the primary enzymes for lactose utilization in Lb. gasseri.
Title: Purification and characterization of two phospho-β-galactosidases, LacG1 and LacG2, from Lactobacillus gasseri ATCC33323(T).
we report that two Arabidopsis homologs of the human histone-binding proteins Retinoblastoma-Associated Protein 46/48 (RbAp46/48), known as MSI4 (or FVE) and MSI5, function in partial redundancy in chromatin silencing of various loci targeted by siRNAs
Title: Arabidopsis homologs of retinoblastoma-associated protein 46/48 associate with a histone deacetylase to act redundantly in chromatin silencing.
FVE, an Arabidopsis homologue of the retinoblastoma-associated protein that regulates flowering time and cold response, binds to chromatin as a large multiprotein complex.
Title: FVE, an Arabidopsis homologue of the retinoblastoma-associated protein that regulates flowering time and cold response, binds to chromatin as a large multiprotein complex.
These results suggest that there may be a conserved function between OsFVE and FVE in the control of flowering time.
Title: Functional conservation and divergence of FVE genes that control flowering time and cold response in rice and Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_127510.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables metal ion binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epigenetic regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within flower development	IMP Inferred from Mutant Phenotype more info
involved_in gene silencing by siRNA-directed DNA methylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within leaf morphogenesis	IMP Inferred from Mutant Phenotype more info
involved_in regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_positive_effect regulation of photoperiodism, flowering	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of timing of transition from vegetative to reproductive phase	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to UV-B	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to diterpene	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to diterpene	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_positive_effect systemic acquired resistance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within trichome morphogenesis	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within unidimensional cell growth	IMP Inferred from Mutant Phenotype more info

Component	Evidence Code	Pubs
part_of Cul4-RING E3 ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of ESC/E(Z) complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	HDA more info	PubMed
located_in cytosol	HDA more info	PubMed
part_of histone deacetylase complex	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in nucleolus	HDA more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Transducin family protein / WD-40 repeat family protein

NP_565456.2

FVE; FUNCTIONS IN: metal ion binding; INVOLVED IN: flower development, unidimensional cell growth, trichome morphogenesis, leaf morphogenesis; LOCATED IN: nucleolus, nucleus, CUL4 RING ubiquitin ligase complex, cytoplasm; EXPRESSED IN: guard cell; CONTAINS InterPro DOMAIN/s: Histone-binding protein RBBP4 (InterPro:IPR022052), WD40 repeat 2 (InterPro:IPR019782), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat (InterPro:IPR001680), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: nucleosome/chromatin assembly factor group C5 (TAIR:AT4G29730.1); Has 27643 Blast hits to 19007 proteins in 669 species: Archae - 18; Bacteria - 3366; Metazoa - 11144; Fungi - 6221; Plants - 3473; Viruses - 0; Other Eukaryotes - 3421 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

8455756..8459642

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_127510.5 → NP_565456.2 Transducin family protein / WD-40 repeat family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_565456.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O22607, Q42322, Q42323, Q58T21, Q93VF7, Q9SLD1

UniProtKB/TrEMBL

A0A178VX04, A0A5S9WZB3

Conserved Domains (3) summary

sd00039
Location:168 → 217

7WD40; WD40 repeat [structural motif]

pfam12265
Location:66 → 134

CAF1C_H4-bd; Histone-binding protein RBBP4 or subunit C of CAF1 complex

cl29593
Location:163 → 477

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...