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    EIN2 NRAMP metal ion transporter family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831889, updated on 18-Sep-2024

    Summary

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    Official Symbol
    EIN2
    Official Full Name
    NRAMP metal ion transporter family protein
    Primary source
    TAIR:AT5G03280
    Locus tag
    AT5G03280
    See related
    Araport:AT5G03280
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATEIN2; CKR1; CYTOKININ RESISTANT 1; ENHANCED RESPONSE TO ABA3; ERA3; ETHYLENE INSENSITIVE 2; F12E4.10; F12E4_10; ORE2; ORE3; ORESARA 2; ORESARA 3; PIR2
    Summary
    Involved in ethylene signal transduction. Acts downstream of CTR1. Positively regulates ORE1 and negatively regulates mir164A,B,C to regulate leaf senescence. A maternally expressed imprinted gene. Mutations in ein2 block ethylene stimulation of flavonol synthesis.
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    Genomic context

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    See EIN2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    8
    Sequence:
    Chromosome: 5; NC_003076.8 (787428..793404)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Phototropic-responsive NPH3 family protein Neighboring gene laccase 11 Neighboring gene lysine decarboxylase family protein Neighboring gene ncRNA Neighboring gene isocitrate dehydrogenase V

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nitric oxide regulates dark-induced leaf senescence through EIN2 in Arabidopsis. Niu YH, et al. J Integr Plant Biol, 2012 Aug. PMID 22765302
    2. Genetic analysis of the effects of polar auxin transport inhibitors on root growth in Arabidopsis thaliana. Fujita H, et al. Plant Cell Physiol, 1996 Dec. PMID 9032965
    3. Regulation of abscisic acid signaling by the ethylene response pathway in Arabidopsis. Ghassemian M, et al. Plant Cell, 2000 Jul. PMID 10899978, Free PMC Article
    4. Arabidopsis EIN2 modulates stress response through abscisic acid response pathway. Wang Y, et al. Plant Mol Biol, 2007 Aug. PMID 17533512
    5. Phosphoproteomic analysis of ethylene-regulated protein phosphorylation in etiolated seedlings of Arabidopsis mutant ein2 using two-dimensional separations coupled with a hybrid quadrupole time-of-flight mass spectrometer. Li H, et al. Proteomics, 2009 Mar. PMID 19253305

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MYB44 regulates PTI by promoting the expression of EIN2 and MPK3/6 in Arabidopsis.
      Title: MYB44 regulates PTI by promoting the expression of EIN2 and MPK3/6 in Arabidopsis.
    2. Arabidopsis EIN2 represses ABA responses during germination and early seedling growth by inactivating HLS1 protein independently of the canonical ethylene pathway.
      Title: Arabidopsis EIN2 represses ABA responses during germination and early seedling growth by inactivating HLS1 protein independently of the canonical ethylene pathway.
    3. Endosperm and Maternal-specific expression of EIN2 in the endosperm affects endosperm cellularization and seed size in Arabidopsis.
      Title: Endosperm and Maternal-specific expression of EIN2 in the endosperm affects endosperm cellularization and seed size in Arabidopsis.
    4. Arabidopsis WRKY71 regulates ethylene-mediated leaf senescence by directly activating EIN2, ORE1 and ACS2 genes.
      Title: Arabidopsis WRKY71 regulates ethylene-mediated leaf senescence by directly activating EIN2, ORE1 and ACS2 genes.
    5. Ethylene signaling in salt-stressed Arabidopsis thaliana ein2-1 and ctr1-1 mutants - A dissection of molecular mechanisms involved in acclimation.
      Title: Ethylene signaling in salt-stressed Arabidopsis thaliana ein2-1 and ctr1-1 mutants - A dissection of molecular mechanisms involved in acclimation.
    6. The TOR-EIN2 axis mediates nuclear signalling to modulate plant growth.
      Title: The TOR-EIN2 axis mediates nuclear signalling to modulate plant growth.
    7. EIN2-directed histone acetylation requires EIN3-mediated positive feedback regulation in response to ethylene.
      Title: EIN2-directed histone acetylation requires EIN3-mediated positive feedback regulation in response to ethylene.
    8. Here the authors identify a chromatin-dependent regulatory mechanism at EIN2 requiring two genes: ETHYLENE-INSENSITIVE6 (EIN6), which is a H3K27me3 demethylase also known as RELATIVE OF EARLY FLOWERING6 (REF6), and EIN6 ENHANCER (EEN), the Arabidopsis homolog of the yeast INO80 chromatin remodeling complex subunit IES6 (INO EIGHTY SUBUNIT).
      Title: Epigenetic silencing of a multifunctional plant stress regulator.
    9. Ethylene-Insensitive Arabidopsis Mutants etr1-1 and ein2-1 Have a Decreased Freezing Tolerance
      Title: Ethylene-Insensitive Arabidopsis Mutants etr1-1 and ein2-1 Have a Decreased Freezing Tolerance.
    10. ENAP1 may potentially mediate ethylene-induced histone acetylation via its interactions with EIN2 C terminus.
      Title: EIN2-dependent regulation of acetylation of histone H3K14 and non-canonical histone H3K23 in ethylene signalling.
    Submit: New GeneRIF Correction See all GeneRIFs (41)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_120406.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding HDA PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within auxin polar transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell death NAS
    Non-traceable Author Statement
    more info
    		  
    acts_upstream_of_or_within cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response by callose deposition in cell wall IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epigenetic regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within establishment of planar polarity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ethylene-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ethylene-activated signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within extracellular ATP signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within jasmonic acid and ethylene-dependent systemic resistance, ethylene mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf senescence IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in metal ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of defense response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phloem or xylem histogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of abscisic acid-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of stomatal movement IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to ethylene IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to hormone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to jasmonic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to molecule of bacterial origin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to oxidative stress TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root hair cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within sugar mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NRAMP metal ion transporter family protein
    NP_195948.1
    • ETHYLENE INSENSITIVE 2 (EIN2); FUNCTIONS IN: transporter activity; INVOLVED IN: in 22 processes; LOCATED IN: membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Natural resistance-associated macrophage protein (InterPro:IPR001046), Ethylene-insensitive 2 (InterPro:IPR017187); BEST Arabidopsis thaliana protein match is: natural resistance-associated macrophage protein 1 (TAIR:AT1G80830.1); Has 4402 Blast hits to 4259 proteins in 1453 species: Archae - 50; Bacteria - 3021; Metazoa - 376; Fungi - 278; Plants - 375; Viruses - 0; Other Eukaryotes - 302 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      787428..793404
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_120406.5 → NP_195948.1  NRAMP metal ion transporter family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195948.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9S814
      UniProtKB/TrEMBL
      A0A178UD45
      Conserved Domains (2) summary
      pfam01566
      Location:38 → 390
      Nramp; Natural resistance-associated macrophage protein
      cl00456
      Location:6 → 419
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9S814.1

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