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    CER2 HXXXD-type acyl-transferase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828553, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CER2
    Official Full Name
    HXXXD-type acyl-transferase family protein
    Primary source
    TAIR:AT4G24510
    Locus tag
    AT4G24510
    See related
    Araport:AT4G24510
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ECERIFERUM 2; F22K18.290; F22K18_290; VC-2; VC2
    Summary
    Encodes a component of the fatty acid elongation machinery required for C28 to C30 fatty acid elongation. It does not require the acyltransferase catalytic site for biological function.
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    Genomic context

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    See CER2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    2
    Sequence:
    Chromosome: 4; NC_003075.7 (12660687..12662656)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Protein kinase superfamily protein Neighboring gene RAB geranylgeranyl transferase alpha subunit 1 Neighboring gene hydroxyproline-rich glycoprotein family protein Neighboring gene ncRNA Neighboring gene P450 reductase 1 Neighboring gene O-fucosyltransferase family protein Neighboring gene AGAMOUS-like 24

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis ECERIFERUM2 is a component of the fatty acid elongation machinery required for fatty acid extension to exceptional lengths. Haslam TM, et al. Plant Physiol, 2012 Nov. PMID 22930748, Free PMC Article
    2. Developmental and hormonal regulation of the arabidopsis CER2 gene that codes for a nuclear-localized protein required for the normal accumulation of cuticular waxes. Xia Y, et al. Plant Physiol, 1997 Nov. PMID 9390429, Free PMC Article
    3. Molecular cloning and characterization of the CER2 gene of Arabidopsis thaliana. Negruk V, et al. Plant J, 1996 Feb. PMID 8820603
    4. The Arabidopsis cer26 mutant, like the cer2 mutant, is specifically affected in the very long chain fatty acid elongation process. Pascal S, et al. Plant J, 2013 Mar. PMID 23384041
    5. ECERIFERUM2-LIKE proteins have unique biochemical and physiological functions in very-long-chain fatty acid elongation. Haslam TM, et al. Plant Physiol, 2015 Mar. PMID 25596184, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Whereas the cer2 mutation impaired the production of wax components longer than 28 carbons, the cer26 mutant was found to be affected in the production of wax components longer than 30 carbons.
      Title: The Arabidopsis cer26 mutant, like the cer2 mutant, is specifically affected in the very long chain fatty acid elongation process.
    2. CER2 localizes to the endoplasmic reticulum, the site of very-long-chain fatty acid biosynthesis.
      Title: Arabidopsis ECERIFERUM2 is a component of the fatty acid elongation machinery required for fatty acid extension to exceptional lengths.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_118584.3

    Gene Ontology Provided by TAIR

    Process Evidence Code Pubs
    acts_upstream_of_or_within pollen development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within very long-chain fatty acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within wax biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    HXXXD-type acyl-transferase family protein
    NP_194182.1
    • ECERIFERUM 2 (CER2); FUNCTIONS IN: transferase activity, transferring acyl groups other than amino-acyl groups, transferase activity; INVOLVED IN: wax biosynthetic process; LOCATED IN: nucleus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Transferase (InterPro:IPR003480); BEST Arabidopsis thaliana protein match is: HXXXD-type acyl-transferase family protein (TAIR:AT4G13840.1); Has 1252 Blast hits to 1252 proteins in 85 species: Archae - 0; Bacteria - 2; Metazoa - 0; Fungi - 10; Plants - 1240; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      12660687..12662656
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_118584.3 → NP_194182.1  HXXXD-type acyl-transferase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_194182.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q39048
      UniProtKB/TrEMBL
      A0A178V1H6, A0A5S9XVJ7
      Conserved Domains (1) summary
      pfam02458
      Location:5 → 415
      Transferase; Transferase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q39048.1

    Gene LinkOut

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