U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    TPK1 thiamine pyrophosphokinase1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839303, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    TPK1
    Official Full Name
    thiamine pyrophosphokinase1
    Primary source
    TAIR:AT1G02880
    Locus tag
    AT1G02880
    See related
    Araport:AT1G02880
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F22D16.12; F22D16_12; thiamin pyrophosphokinase1
    Summary
    Encodes a thiamine pyrophosphokinase capable of producing thiamine pyrophosphate from free thiamine.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See TPK1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    7
    Sequence:
    Chromosome: 1; NC_003070.9 (642505..644903, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene nucleolar-like protein Neighboring gene ncRNA Neighboring gene miscRNA Neighboring gene AAA-type ATPase family protein Neighboring gene rapid alkalinization factor 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Allelic variation in the vacuolar TPK1 channel affects its calcium dependence and may impact on stomatal conductance. Hartley TN, et al. FEBS Lett, 2016 Jan. PMID 26765783
    2. KIN7 Kinase Regulates the Vacuolar TPK1 K(+) Channel during Stomatal Closure. Isner JC, et al. Curr Biol, 2018 Feb 5. PMID 29395926
    3. Thiamin pyrophosphokinase is required for thiamin cofactor activation in Arabidopsis. Ajjawi I, et al. Plant Mol Biol, 2007 Sep. PMID 17611796
    4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The TPK1 vacuolar K(+) channel is important for abscisic acid (ABA)- and CO2-mediated stomatal closure. During ABA- and CO2-mediated closure, TPK1 is phosphorylated and activated by the KIN7 receptor-like protein kinase (RLK), which co-expresses in the tonoplast and plasma membrane.
      Title: KIN7 Kinase Regulates the Vacuolar TPK1 K(+) Channel during Stomatal Closure.
    2. Data suggest that different vacuolar TPK1 versions found in ecotypes Landsberg-0 and Kas-2 that are due to single nucleotide polymorphisms are related to variations in Ca2+ dependence and affect water loss from leaves.
      Title: Allelic variation in the vacuolar TPK1 channel affects its calcium dependence and may impact on stomatal conductance.
    3. thiamin pyrophosphokinase activity provides the sole mechanism by which exogenous and de novo derived thiamin is converted to the enzyme cofactor Thiamin pyrophosphate
      Title: Thiamin pyrophosphokinase is required for thiamin cofactor activation in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Homology

    NM_001123747.1
    NM_001331363.1
    NM_100169.2
    NM_179248.1
    NM_179249.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables thiamine binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thiamine diphosphokinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables thiamine diphosphokinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in thiamine diphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in thiamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within thiamine metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    thiamine pyrophosphokinase1
    NP_001117219.1
    • thiamin pyrophosphokinase1 (TPK1); FUNCTIONS IN: thiamin diphosphokinase activity; INVOLVED IN: thiamin metabolic process; LOCATED IN: cytosol; EXPRESSED IN: 6 plant structures; CONTAINS InterPro DOMAIN/s: Thiamin pyrophosphokinase, vitamin B1-binding domain (InterPro:IPR007373), Thiamin pyrophosphokinase (InterPro:IPR006282), Thiamin pyrophosphokinase, catalytic domain (InterPro:IPR007371); BEST Arabidopsis thaliana protein match is: thiamin pyrophosphokinase 2 (TAIR:AT2G44750.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_563669.1
    • thiamin pyrophosphokinase1 (TPK1); FUNCTIONS IN: thiamin diphosphokinase activity; INVOLVED IN: thiamin metabolic process; LOCATED IN: cytosol; EXPRESSED IN: 6 plant structures; CONTAINS InterPro DOMAIN/s: Thiamin pyrophosphokinase, vitamin B1-binding domain (InterPro:IPR007373), Thiamin pyrophosphokinase, eukaryotic (InterPro:IPR016966), Thiamin pyrophosphokinase (InterPro:IPR006282), Thiamin pyrophosphokinase, catalytic domain (InterPro:IPR007371); BEST Arabidopsis thaliana protein match is: thiamin pyrophosphokinase 2 (TAIR:AT2G44750.2); Has 1306 Blast hits to 1304 proteins in 531 species: Archae - 0; Bacteria - 677; Metazoa - 135; Fungi - 134; Plants - 93; Viruses - 0; Other Eukaryotes - 267 (source: NCBI BLink).
    NP_849579.1
    • thiamin pyrophosphokinase1 (TPK1); FUNCTIONS IN: thiamin diphosphokinase activity; INVOLVED IN: thiamin metabolic process; LOCATED IN: cytosol; EXPRESSED IN: 6 plant structures; CONTAINS InterPro DOMAIN/s: Thiamin pyrophosphokinase, vitamin B1-binding domain (InterPro:IPR007373), Thiamin pyrophosphokinase (InterPro:IPR006282), Thiamin pyrophosphokinase, catalytic domain (InterPro:IPR007371); BEST Arabidopsis thaliana protein match is: thiamin pyrophosphokinase 2 (TAIR:AT2G44750.2); Has 1216 Blast hits to 1216 proteins in 497 species: Archae - 0; Bacteria - 615; Metazoa - 133; Fungi - 131; Plants - 88; Viruses - 0; Other Eukaryotes - 249 (source: NCBI BLink).
    NP_849580.1
    • thiamin pyrophosphokinase1 (TPK1); FUNCTIONS IN: thiamin diphosphokinase activity; INVOLVED IN: thiamin metabolic process; LOCATED IN: cytosol; EXPRESSED IN: 6 plant structures; CONTAINS InterPro DOMAIN/s: Thiamin pyrophosphokinase, vitamin B1-binding domain (InterPro:IPR007373), Thiamin pyrophosphokinase, eukaryotic (InterPro:IPR016966), Thiamin pyrophosphokinase (InterPro:IPR006282), Thiamin pyrophosphokinase, catalytic domain (InterPro:IPR007371); BEST Arabidopsis thaliana protein match is: thiamin pyrophosphokinase 2 (TAIR:AT2G44750.2); Has 1298 Blast hits to 1296 proteins in 527 species: Archae - 0; Bacteria - 670; Metazoa - 134; Fungi - 134; Plants - 93; Viruses - 0; Other Eukaryotes - 267 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      642505..644903 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001331362.1 → NP_001321569.1  thiamine pyrophosphokinase1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0Z2Y6
      Conserved Domains (1) summary
      PLN02714
      Location:2 → 185
      PLN02714; thiamin pyrophosphokinase

    2. NM_100169.2 → NP_563669.1  thiamine pyrophosphokinase1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_563669.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654F761
      Conserved Domains (2) summary
      cd07995
      Location:24 → 250
      TPK; Thiamine pyrophosphokinase
      PLN02714
      Location:24 → 252
      PLN02714; thiamin pyrophosphokinase

    3. NM_179249.3 → NP_849580.1  thiamine pyrophosphokinase1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849580.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DGU7, Q93Z45, Q9SRY1
      UniProtKB/TrEMBL
      A0A178WKT3, A0A5S9SBE4, A0A654F761
      Conserved Domains (1) summary
      PLN02714
      Location:27 → 255
      PLN02714; thiamin pyrophosphokinase

    4. NM_001331363.1 → NP_001321568.1  thiamine pyrophosphokinase1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8ARA0, A0A654F761

    5. NM_001123747.1 → NP_001117219.1  thiamine pyrophosphokinase1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001117219.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3H6N1, C0Z2Y6
      Conserved Domains (2) summary
      cd07995
      Location:1 → 166
      TPK; Thiamine pyrophosphokinase
      PLN02714
      Location:1 → 168
      PLN02714; thiamin pyrophosphokinase

    6. NM_179248.1 → NP_849579.1  thiamine pyrophosphokinase1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849579.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0Z2Y6
      Conserved Domains (1) summary
      PLN02714
      Location:2 → 185
      PLN02714; thiamin pyrophosphokinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B9DGU7.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.