HBI1 basic helix-loop-helix (bHLH) DNA-binding superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: HBI1
Official Full Name: basic helix-loop-helix (bHLH) DNA-binding superfamily protein
Primary source: TAIR:AT2G18300
Locus tag: AT2G18300
See related: Araport:AT2G18300
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: HOMOLOG OF BEE2 INTERACTING WITH IBH 1; T30D6.19; T30D6_19
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Genomic context

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See HBI1 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 7

Sequence:: Chromosome: 2; NC_003071.7 (7952404..7954785, complement)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HBI transcription factor-mediated ROS homeostasis regulates nitrate signal transduction.
Title: HBI transcription factor-mediated ROS homeostasis regulates nitrate signal transduction.
results suggest that HBI1 acts as a new CRY1-interacting protein and that the signaling mechanism of CRY1 involves repression of HBI1 transcriptional activity by direct CRY1-HBI1 interaction
Title: CRY1 interacts directly with HBI1 to regulate its transcriptional activity and photomorphogenesis in Arabidopsis.
Class I TCP Transcription Factors Target the Gibberellin Biosynthesis Gene GA20ox1 and the Growth-Promoting Genes HBI1 and PRE6 during Thermomorphogenic Growth in Arabidopsis.
Title: Class I TCP Transcription Factors Target the Gibberellin Biosynthesis Gene GA20ox1 and the Growth-Promoting Genes HBI1 and PRE6 during Thermomorphogenic Growth in Arabidopsis.
HBI1, as a component of the central growth regulation circuit, functions as a major node of crosstalk that mediates a trade-off between growth and immunity in plants.[HBI1]
Title: The bHLH transcription factor HBI1 mediates the trade-off between growth and pathogen-associated molecular pattern-triggered immunity in Arabidopsis.
HBI1 is a positive regulator of BR-triggered responses, and the negative effect of PTI is likely due to the antagonism between BR and PTI signaling. [HBI1]
Title: Antagonistic regulation of growth and immunity by the Arabidopsis basic helix-loop-helix transcription factor homolog of brassinosteroid enhanced expression2 interacting with increased leaf inclination1 binding bHLH1.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_127388.4

Supported by ESTs:

NM_179645.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables bHLH transcription factor binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin DNA binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables transcription cis-regulatory region binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within mRNA transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of pattern recognition receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to cytokinin	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to hormone	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within unidimensional cell growth	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: basic helix-loop-helix (bHLH) DNA-binding superfamily protein

NP_001189548.1

basic helix-loop-helix (bHLH) DNA-binding superfamily protein; FUNCTIONS IN: sequence-specific DNA binding transcription factor activity; INVOLVED IN: response to cytokinin stimulus, regulation of transcription; LOCATED IN: nucleus; EXPRESSED IN: 13 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: Helix-loop-helix DNA-binding domain (InterPro:IPR001092), Helix-loop-helix DNA-binding (InterPro:IPR011598); BEST Arabidopsis thaliana protein match is: BR enhanced expression 2 (TAIR:AT4G36540.1).

NP_565434.1

basic helix-loop-helix (bHLH) DNA-binding superfamily protein; FUNCTIONS IN: sequence-specific DNA binding transcription factor activity; INVOLVED IN: response to cytokinin stimulus, regulation of transcription; LOCATED IN: nucleus; EXPRESSED IN: 13 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: Helix-loop-helix DNA-binding domain (InterPro:IPR001092), Helix-loop-helix DNA-binding (InterPro:IPR011598); BEST Arabidopsis thaliana protein match is: BR enhanced expression 2 (TAIR:AT4G36540.2); Has 2065 Blast hits to 2057 proteins in 127 species: Archae - 0; Bacteria - 4; Metazoa - 84; Fungi - 45; Plants - 1914; Viruses - 0; Other Eukaryotes - 18 (source: NCBI BLink).

NP_849976.1

basic helix-loop-helix (bHLH) DNA-binding superfamily protein; FUNCTIONS IN: sequence-specific DNA binding transcription factor activity; INVOLVED IN: response to cytokinin stimulus, regulation of transcription; LOCATED IN: nucleus; EXPRESSED IN: 13 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: Helix-loop-helix DNA-binding domain (InterPro:IPR001092), Helix-loop-helix DNA-binding (InterPro:IPR011598); BEST Arabidopsis thaliana protein match is: BR enhanced expression 2 (TAIR:AT4G36540.1); Has 2064 Blast hits to 2056 proteins in 122 species: Archae - 0; Bacteria - 4; Metazoa - 81; Fungi - 43; Plants - 1919; Viruses - 0; Other Eukaryotes - 17 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

7952404..7954785 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001202619.2 → NP_001189548.1 basic helix-loop-helix (bHLH) DNA-binding superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001189548.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A178VRT2, F4IQH8

Conserved Domains (2) summary

smart00353
Location:197 → 246

HLH; helix loop helix domain

pfam12751
Location:262 → 308

Vac7; Vacuolar segregation subunit 7
NM_179645.3 → NP_849976.1 basic helix-loop-helix (bHLH) DNA-binding superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_849976.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8S3D8, Q945K8, Q9ZPW3

UniProtKB/TrEMBL

A0A178VRT2

Conserved Domains (2) summary

smart00353
Location:197 → 246

HLH; helix loop helix domain

pfam12751
Location:262 → 308

Vac7; Vacuolar segregation subunit 7
NM_127388.4 → NP_565434.1 basic helix-loop-helix (bHLH) DNA-binding superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_565434.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A178VSF5

Conserved Domains (2) summary

smart00353
Location:197 → 246

HLH; helix loop helix domain

pfam12751
Location:262 → 306

Vac7; Vacuolar segregation subunit 7