TWN2 valyl-tRNA synthetase / valine-tRNA ligase (VALRS) [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: TWN2
Official Full Name: valyl-tRNA synthetase / valine-tRNA ligase (VALRS)
Primary source: TAIR:AT1G14610
Locus tag: AT1G14610
See related: Araport:AT1G14610
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: T5E21.11; T5E21_11; TWIN 2; VALRS; VALYL TRNA SYNTHETASE
Summary: Required for proper proliferation of basal cells.
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Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

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Title: Bovine mannosidosis--a model lysosomal storage disease.
class I valyl-tRNA synthetase and class II threonyl-tRNA synthetase genes encode the cytosolic and mitochondrial forms of the enzymes by alternative use of two in-frame initiation codons.
Title: Characterization of two bifunctional Arabdopsis thaliana genes coding for mitochondrial and cytosolic forms of valyl-tRNA synthetase and threonyl-tRNA synthetase by alternative use of two in-frame AUGs.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

NM_101328.4

Function	Evidence Code	Pubs
enables aminoacyl-tRNA editing activity	IEA Inferred from Electronic Annotation more info
enables valine-tRNA ligase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within embryo development ending in seed dormancy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in valyl-tRNA aminoacylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chloroplast	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in extracellular region	HDA more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

NP_172913.1

TWIN 2 (TWN2); FUNCTIONS IN: valine-tRNA ligase activity, aminoacyl-tRNA ligase activity, nucleotide binding, ATP binding; INVOLVED IN: tRNA aminoacylation for protein translation, embryo development ending in seed dormancy; LOCATED IN: mitochondrion, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Valyl-tRNA synthetase, class Ia (InterPro:IPR002303), Aminoacyl-tRNA synthetase, class I, conserved site (InterPro:IPR001412), Aminoacyl-tRNA synthetase, class 1a, anticodon-binding (InterPro:IPR009080), Rossmann-like alpha/beta/alpha sandwich fold (InterPro:IPR014729), Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing (InterPro:IPR009008), Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding (InterPro:IPR013155), Aminoacyl-tRNA synthetase, class Ia (InterPro:IPR002300), Valyl-tRNA synthetase, class Ia, N-terminal (InterPro:IPR019754); BEST Arabidopsis thaliana protein match is: ATP binding;valine-tRNA ligases;aminoacyl-tRNA ligases;nucleotide binding;ATP binding;aminoacyl-tRNA ligases (TAIR:AT5G16715.1); Has 39194 Blast hits to 36732 proteins in 3122 species: Archae - 839; Bacteria - 19755; Metazoa - 1534; Fungi - 892; Plants - 369; Viruses - 3; Other Eukaryotes - 15802 (source: NCBI BLink).

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