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    ATR1 P450 reductase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828554, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ATR1
    Official Full Name
    P450 reductase 1
    Primary source
    TAIR:AT4G24520
    Locus tag
    AT4G24520
    See related
    Araport:AT4G24520
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AR1; ARABIDOPSIS CYTOCHROME REDUCTASE; F22K18.280; F22K18_280; P450 reductase 1
    Summary
    Encodes a cyp450 reductase likely to be involved in phenylpropanoid metabolism.
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    Genomic context

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    See ATR1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    17
    Sequence:
    Chromosome: 4; NC_003075.7 (12662561..12667262, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene hydroxyproline-rich glycoprotein family protein Neighboring gene HXXXD-type acyl-transferase family protein Neighboring gene ncRNA Neighboring gene O-fucosyltransferase family protein Neighboring gene AGAMOUS-like 24

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. G2/M-checkpoint activation in fasciata1 rescues an aberrant S-phase checkpoint but causes genome instability. Eekhout T, et al. Plant Physiol, 2021 Aug 3. PMID 34618100, Free PMC Article
    2. Cloning, yeast expression, and characterization of the coupling of two distantly related Arabidopsis thaliana NADPH-cytochrome P450 reductases with P450 CYP73A5. Urban P, et al. J Biol Chem, 1997 Aug 1. PMID 9235908
    3. Induction of Arabidopsis tryptophan pathway enzymes and camalexin by amino acid starvation, oxidative stress, and an abiotic elicitor. Zhao J, et al. Plant Cell, 1998 Mar. PMID 9501110, Free PMC Article
    4. Protein and metabolite composition of Arabidopsis stress granules. Kosmacz M, et al. New Phytol, 2019 May. PMID 30664249
    5. A DEK domain-containing protein modulates chromatin structure and function in Arabidopsis. Waidmann S, et al. Plant Cell, 2014 Nov. PMID 25387881, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. G2/M-checkpoint activation in fasciata1 rescues an aberrant S-phase checkpoint but causes genome instability.
      Title: G2/M-checkpoint activation in fasciata1 rescues an aberrant S-phase checkpoint but causes genome instability.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_118585.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables NADPH-hemoprotein reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NADPH-hemoprotein reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phenylpropanoid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to oxidative stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    P450 reductase 1
    NP_001190823.1
    • P450 reductase 1 (ATR1); CONTAINS InterPro DOMAIN/s: Oxidoreductase FAD/NAD(P)-binding (InterPro:IPR001433), Ferredoxin reductase-type FAD-binding domain (InterPro:IPR017927), Riboflavin synthase-like beta-barrel (InterPro:IPR017938), FAD-binding, type 1 (InterPro:IPR003097), Flavodoxin/nitric oxide synthase (InterPro:IPR008254), Flavoprotein pyridine nucleotide cytochrome reductase (InterPro:IPR001709), NADPH Cytochrome P450 Reductase (InterPro:IPR015702); BEST Arabidopsis thaliana protein match is: P450 reductase 2 (TAIR:AT4G30210.2).
    NP_194183.1
    • P450 reductase 1 (ATR1); FUNCTIONS IN: NADPH-hemoprotein reductase activity; INVOLVED IN: response to oxidative stress, phenylpropanoid metabolic process; LOCATED IN: endoplasmic reticulum; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Ferredoxin reductase-type FAD-binding domain (InterPro:IPR017927), Flavodoxin/nitric oxide synthase (InterPro:IPR008254), Oxidoreductase FAD/NAD(P)-binding (InterPro:IPR001433), Riboflavin synthase-like beta-barrel (InterPro:IPR017938), FAD-binding, type 1 (InterPro:IPR003097), Flavoprotein pyridine nucleotide cytochrome reductase (InterPro:IPR001709), NADPH Cytochrome P450 Reductase (InterPro:IPR015702); BEST Arabidopsis thaliana protein match is: P450 reductase 2 (TAIR:AT4G30210.2); Has 6349 Blast hits to 5969 proteins in 1541 species: Archae - 6; Bacteria - 2994; Metazoa - 1048; Fungi - 898; Plants - 566; Viruses - 0; Other Eukaryotes - 837 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      12662561..12667262 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001203894.1 → NP_001190823.1  P450 reductase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190823.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9XW56, F4JQY4
      Conserved Domains (3) summary
      cd06204
      Location:284 → 688
      CYPOR; NADPH cytochrome p450 reductase (CYPOR) serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine synthase reductases. CYPOR transfers two electrons from NADPH to the heme of cytochrome p450 via ...
      COG0369
      Location:82 → 688
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
      pfam00258
      Location:87 → 226
      Flavodoxin_1; Flavodoxin

    2. NM_118585.4 → NP_194183.1  P450 reductase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_194183.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q39035, Q9SB48
      UniProtKB/TrEMBL
      A0A178UWR2, A0A5S9XW56
      Conserved Domains (2) summary
      cd06204
      Location:288 → 692
      CYPOR; NADPH cytochrome p450 reductase (CYPOR) serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine synthase reductases. CYPOR transfers two electrons from NADPH to the heme of cytochrome p450 via ...
      pfam00258
      Location:87 → 230
      Flavodoxin_1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SB48.1

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