GRV2 DNAJ heat shock N-terminal domain-containing protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: GRV2
Official Full Name: DNAJ heat shock N-terminal domain-containing protein
Primary source: TAIR:AT2G26890
Locus tag: AT2G26890
See related: Araport:AT2G26890
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F12C20.7; F12C20_7; GRAVITROPISM DEFECTIVE 2; KAM2; KATAMARI2
Summary: GRV2 has sequence similarity to the C. elegans protein RME-8 which is involved in endocytosis. grv2 mutants result in a reduction in gravitropic response in hypocotyls and shoots but do not affect root gravitropism. The mutants are defective in amyloplast sedimentation.
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Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

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The Arabidopsis katamari2 Mutant Exhibits a Hypersensitive Seedling Arrest Response at the Phase Transition from Heterotrophic to Autotrophic Growth.
Title: The Arabidopsis katamari2 Mutant Exhibits a Hypersensitive Seedling Arrest Response at the Phase Transition from Heterotrophic to Autotrophic Growth.
KAM2/GRV2 is required for proper formation of the endosomes involving protein trafficking to the vacuoles and determination of growth axis of the embryo.
Title: Arabidopsis KAM2/GRV2 is required for proper endosome formation and functions in vacuolar sorting and determination of the embryo growth axis.
The gravitropism defective 2 (grv2) mutants of Arabidopsis show reduced shoot phototropism and gravitropism. [GRV2]
Title: The gravitropism defective 2 mutants of Arabidopsis are deficient in a protein implicated in endocytosis in Caenorhabditis elegans.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

NM_128246.5

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within amyloplast organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell division	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryo development ending in seed dormancy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endocytosis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within endosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in late endosome to vacuole transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative gravitropism	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phototropism	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in positive gravitropism	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein targeting to vacuole	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein targeting to vacuole	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of early endosome to late endosome transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vacuole organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	HDA more info	PubMed
NOT located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info
located_in peroxisome	HDA more info	PubMed
NOT located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed
NOT located_in vacuolar membrane	IDA Inferred from Direct Assay more info	PubMed
located_in vacuolar membrane	IDA Inferred from Direct Assay more info	PubMed
located_in vacuole	HDA more info	PubMed

NP_180257.3

GRAVITROPISM DEFECTIVE 2 (GRV2); FUNCTIONS IN: binding, heat shock protein binding; INVOLVED IN: in 10 processes; LOCATED IN: in 6 components; EXPRESSED IN: 30 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Molecular chaperone, heat shock protein, Hsp40, DnaJ (InterPro:IPR015609), Heat shock protein DnaJ, N-terminal (InterPro:IPR001623), Armadillo-type fold (InterPro:IPR016024); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

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The following sections contain reference sequences that belong to a specific genome build. Explain