U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    PORA protochlorophyllide oxidoreductase A [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835507, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    PORA
    Official Full Name
    protochlorophyllide oxidoreductase A
    Primary source
    TAIR:AT5G54190
    Locus tag
    AT5G54190
    See related
    Araport:AT5G54190
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    K18G13.7; K18G13_7; protochlorophyllide oxidoreductase A
    Summary
    light-dependent NADPH:protochlorophyllide oxidoreductase A
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See PORA in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    4
    Sequence:
    Chromosome: 5; NC_003076.8 (21990864..21992814, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene plastid transcriptionally active 15 Neighboring gene miscRNA Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. MGDG, PG and SQDG regulate the activity of light-dependent protochlorophyllide oxidoreductase. Gabruk M, et al. Biochem J, 2017 Mar 23. PMID 28188256
    2. Insight into the oligomeric structure of PORA from A. thaliana. Gabruk M, et al. Biochim Biophys Acta, 2016 Dec. PMID 27693048
    3. Arabidopsis light-dependent NADPH: protochlorophyllide oxidoreductase A (PORA) is essential for normal plant growth and development: an addendum. Kim C, et al. Plant Mol Biol, 2012 Sep. PMID 22850939
    4. Arabidopsis light-dependent protochlorophyllide oxidoreductase A (PORA) is essential for normal plant growth and development. Paddock T, et al. Plant Mol Biol, 2012 Mar. PMID 22278767
    5. Cell growth defect factor 1 is crucial for the plastid import of NADPH:protochlorophyllide oxidoreductase A in Arabidopsis thaliana. Reinbothe S, et al. Proc Natl Acad Sci U S A, 2015 May 5. PMID 25901327, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Photocatalytic LPOR forms helical lattices that shape membranes for chlorophyll synthesis.
      Title: Photocatalytic LPOR forms helical lattices that shape membranes for chlorophyll synthesis.
    2. The catalytic motifs of adjacent subunits become close to each other upon binding of substrates. Identified two mutations of PORA that disturbed its oligomerisation properties: Delta85-88 and Delta240-270. Additionally, a complete loss of the catalytic activity was observed for the following mutations: Delta189-194, Delta240-270, Delta318-331 and Delta392-393.
      Title: Insight into the oligomeric structure of PORA from A. thaliana.
    3. Monogalactosyldiacylglycerol, phosphatidylglycerol and sulfoquinovosyl diacylglycerol regulate the activity of light-dependent protochlorophyllide oxidoreductase.
      Title: MGDG, PG and SQDG regulate the activity of light-dependent protochlorophyllide oxidoreductase.
    4. reconstituted Pchlide-POR-NADPH complexes showed fluorescence maxima at 77 K
      Title: Photoactive protochlorophyllide-enzyme complexes reconstituted with PORA, PORB and PORC proteins of A. thaliana: fluorescence and catalytic properties.
    5. Cell growth defect factor 1 has a critical role in plastid import of NADPH: protochlorophyllide oxidoreductase A in Arabidopsis thaliana
      Title: Cell growth defect factor 1 is crucial for the plastid import of NADPH:protochlorophyllide oxidoreductase A in Arabidopsis thaliana.
    6. Results suggest that the lack of stomata in porA-1 may contribute to the dwarfed phenotype of the mutant and the essential role of PORA during plant development and stomata formation.
      Title: Arabidopsis light-dependent NADPH: protochlorophyllide oxidoreductase A (PORA) is essential for normal plant growth and development: an addendum.
    7. PORA-specific functions in photomorphogenesis and plant development, especially in etioplast development
      Title: Arabidopsis light-dependent protochlorophyllide oxidoreductase A (PORA) is essential for normal plant growth and development.
    8. In response to illumination, light-dependent chlorophyll production, thylakoid stacking and photomorphogenesis are also restored in PORA-overexpressing porB-1 porC-1 seedlings and adult plants.
      Title: Arabidopsis protochlorophyllide oxidoreductase A (PORA) restores bulk chlorophyll synthesis and normal development to a porB porC double mutant.
    9. Interaction of Toc33 and Oep16 with PORA protein transport in A. thaliana.
      Title: A role of Toc33 in the protochlorophyllide-dependent plastid import pathway of NADPH:protochlorophyllide oxidoreductase (POR) A.
    10. The analysis of PORA and PORB import into plastids of intact seedlings revealed an unexpected multiplicity of import routes that differed by their substrate, cell, tissue and organ specificities.
      Title: Multiplicity of different cell- and organ-specific import routes for the NADPH-protochlorophyllide oxidoreductases A and B in plastids of Arabidopsis seedlings.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help
    NM_001036995.1
    NM_124799.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protochlorophyllide reductase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protochlorophyllide reductase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables protochlorophyllide reductase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chlorophyll biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chlorophyll biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in photomorphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to ethylene IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in skotomorphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast thylakoid HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    protochlorophyllide oxidoreductase A
    NP_001032072.1
    • protochlorophyllide oxidoreductase A (PORA); FUNCTIONS IN: oxidoreductase activity, protochlorophyllide reductase activity; INVOLVED IN: chlorophyll biosynthetic process, response to ethylene stimulus; LOCATED IN: chloroplast; EXPRESSED IN: 11 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Light-dependent protochlorophyllide reductase (InterPro:IPR005979), NAD(P)-binding domain (InterPro:IPR016040), Short-chain dehydrogenase/reductase SDR (InterPro:IPR002198); BEST Arabidopsis thaliana protein match is: protochlorophyllide oxidoreductase B (TAIR:AT4G27440.2); Has 5533 Blast hits to 5523 proteins in 759 species: Archae - 38; Bacteria - 1884; Metazoa - 1114; Fungi - 682; Plants - 679; Viruses - 0; Other Eukaryotes - 1136 (source: NCBI BLink).
    NP_200230.1
    • protochlorophyllide oxidoreductase A (PORA); FUNCTIONS IN: oxidoreductase activity, protochlorophyllide reductase activity; INVOLVED IN: chlorophyll biosynthetic process, response to ethylene stimulus; LOCATED IN: chloroplast; EXPRESSED IN: 11 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Light-dependent protochlorophyllide reductase (InterPro:IPR005979), NAD(P)-binding domain (InterPro:IPR016040), Glucose/ribitol dehydrogenase (InterPro:IPR002347), Short-chain dehydrogenase/reductase SDR (InterPro:IPR002198); BEST Arabidopsis thaliana protein match is: protochlorophyllide oxidoreductase B (TAIR:AT4G27440.2); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      21990864..21992814 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124799.4 → NP_200230.1  protochlorophyllide oxidoreductase A [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200230.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DGY6, Q42536, Q9FK22
      UniProtKB/TrEMBL
      A0A178UR02, A0A5S9YDU5
      Conserved Domains (1) summary
      PLN00015
      Location:96 → 403
      PLN00015; protochlorophyllide reductase

    2. NM_001036995.1 → NP_001032072.1  protochlorophyllide oxidoreductase A [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001032072.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q42536
      Conserved Domains (1) summary
      PLN00015
      Location:1 → 282
      PLN00015; protochlorophyllide reductase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q42536.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.