U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Mechanosensitive ion channel family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816204, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Full Name
    Mechanosensitive ion channel family protein
    Primary source
    TAIR:AT2G17010
    Locus tag
    AT2G17010
    See related
    Araport:AT2G17010
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F6P23.17; F6P23_17
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    chromosome: 2
    Exon count:
    5
    Sequence:
    Chromosome: 2; NC_003071.7 (7392762..7395985, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Major facilitator superfamily protein Neighboring gene Mechanosensitive ion channel family protein Neighboring gene F-box/RNI-like superfamily protein Neighboring gene F-box SKIP23-like protein (DUF295)

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The Tension-sensitive Ion Transport Activity of MSL8 is Critical for its Function in Pollen Hydration and Germination. Hamilton ES, et al. Plant Cell Physiol, 2017 Jul 1. PMID 28339550
    2. Mechanosensitive channel MSL8 regulates osmotic forces during pollen hydration and germination. Hamilton ES, et al. Science, 2015 Oct 23. PMID 26494758, Free PMC Article
    3. SYP72 interacts with the mechanosensitive channel MSL8 to protect pollen from hypoosmotic shock during hydration. Zhou X, et al. Nat Commun, 2022 Jan 10. PMID 35013278, Free PMC Article
    4. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SYP72 interacts with the mechanosensitive channel MSL8 to protect pollen from hypoosmotic shock during hydration.
      Title: SYP72 interacts with the mechanosensitive channel MSL8 to protect pollen from hypoosmotic shock during hydration.
    2. An intact MSL8 channel is required for normal pollen function during hydration and germination. These data establish MSL8 as the first plant MS channel to fulfill previously established criteria for assignment as a mechanotransducer.
      Title: The Tension-sensitive Ion Transport Activity of MSL8 is Critical for its Function in Pollen Hydration and Germination.
    3. MSL8 thus senses and responds to changes in membrane tension associated with pollen hydration and germination.
      Title: Mechanosensitive channel MSL8 regulates osmotic forces during pollen hydration and germination.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help
    NM_001335527.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables mechanosensitive monoatomic ion channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within pollen germination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen hydration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endomembrane system IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in pollen tube IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Mechanosensitive ion channel family protein
    NP_001318236.1
    • Mechanosensitive ion channel family protein; FUNCTIONS IN: molecular_function unknown; INVOLVED IN: transmembrane transport; LOCATED IN: membrane; CONTAINS InterPro DOMAIN/s: Membrane protein, At2g17000, predicted (InterPro:IPR016688), Mechanosensitive ion channel MscS (InterPro:IPR006685), Like-Sm ribonucleoprotein (LSM)-related domain (InterPro:IPR010920); BEST Arabidopsis thaliana protein match is: Mechanosensitive ion channel family protein (TAIR:AT2G17000.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      7392762..7395985 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001335528.1 → NP_001323613.1  Mechanosensitive ion channel family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AXM8

    2. NM_001335527.1 → NP_001318236.1  Mechanosensitive ion channel family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4IME2
      UniProtKB/TrEMBL
      A0A178VYZ4, A0A5S9WYQ2, A0A654ETH4
      Conserved Domains (1) summary
      cl39057
      Location:706 → 876
      MS_channel; Mechanosensitive ion channel
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4IME2.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.