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    CAC2 acetyl Co-enzyme a carboxylase biotin carboxylase subunit [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 833497, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CAC2
    Official Full Name
    acetyl Co-enzyme a carboxylase biotin carboxylase subunit
    Primary source
    TAIR:AT5G35360
    Locus tag
    AT5G35360
    See related
    Araport:AT5G35360
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    acetyl Co-enzyme a carboxylase biotin carboxylase subunit; ACETYL-COA CARBOXYLASE; T26D22.8; T26D22_8
    Summary
    Encodes biotin carboxylase subunit (CAC2).
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    Genomic context

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    See CAC2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    16
    Sequence:
    Chromosome: 5; NC_003076.8 (13584104..13588496)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene S-locus lectin protein kinase family protein Neighboring gene uncharacterized protein Neighboring gene kinase with adenine nucleotide alpha hydrolases-like domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biochemical and molecular biological characterization of CAC2, the Arabidopsis thaliana gene coding for the biotin carboxylase subunit of the plastidic acetyl-coenzyme A carboxylase. Sun J, et al. Plant Physiol, 1997 Dec. PMID 9414551, Free PMC Article
    2. Chloroplast acetyl-CoA carboxylase activity is 2-oxoglutarate-regulated by interaction of PII with the biotin carboxyl carrier subunit. Feria Bourrellier AB, et al. Proc Natl Acad Sci U S A, 2010 Jan 5. PMID 20018655, Free PMC Article
    3. Arabidopsis scaffold protein RACK1A interacts with diverse environmental stress and photosynthesis related proteins. Kundu N, et al. Plant Signal Behav, 2013 May. PMID 23435172, Free PMC Article
    4. The 14-3-3 isoforms chi and epsilon differentially bind client proteins from developing Arabidopsis seed. Swatek KN, et al. J Proteome Res, 2011 Sep 2. PMID 21766784
    5. The oligomeric stromal proteome of Arabidopsis thaliana chloroplasts. Peltier JB, et al. Mol Cell Proteomics, 2006 Jan. PMID 16207701

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001036891.2
    NM_001203493.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables acetyl-CoA carboxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acetyl-CoA carboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables biotin carboxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables biotin carboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within fatty acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in malonyl-CoA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast stroma HDA PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    acetyl Co-enzyme a carboxylase biotin carboxylase subunit
    NP_001031968.1
    • acetyl Co-enzyme a carboxylase biotin carboxylase subunit (CAC2); FUNCTIONS IN: biotin carboxylase activity, acetyl-CoA carboxylase activity; INVOLVED IN: fatty acid biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Carbamoyl phosphate synthase, large subunit, N-terminal (InterPro:IPR005481), Carbamoyl phosphate synthetase, large subunit, ATP-binding (InterPro:IPR005479), Acetyl-CoA carboxylase, biotin carboxylase (InterPro:IPR004549), PreATP-grasp-like fold (InterPro:IPR016185), Biotin carboxylation domain (InterPro:IPR011764), ATP-grasp fold (InterPro:IPR011761), Biotin carboxylase, C-terminal (InterPro:IPR005482), ATP-grasp fold, subdomain 2 (InterPro:IPR013816), Pre-ATP-grasp fold (InterPro:IPR013817), Rudiment single hybrid motif (InterPro:IPR011054); BEST Arabidopsis thaliana protein match is: methylcrotonyl-CoA carboxylase alpha chain, mitochondrial / 3-methylcrotonyl-CoA carboxylase 1 (MCCA) (TAIR:AT1G03090.2); Has 34137 Blast hits to 30069 proteins in 3695 species: Archae - 501; Bacteria - 21005; Metazoa - 1664; Fungi - 1001; Plants - 762; Viruses - 0; Other Eukaryotes - 9204 (source: NCBI BLink).
    NP_001190422.1
    • acetyl Co-enzyme a carboxylase biotin carboxylase subunit (CAC2); CONTAINS InterPro DOMAIN/s: Carbamoyl phosphate synthase, large subunit, N-terminal (InterPro:IPR005481), Carbamoyl phosphate synthetase, large subunit, ATP-binding (InterPro:IPR005479), Acetyl-CoA carboxylase, biotin carboxylase (InterPro:IPR004549), PreATP-grasp-like fold (InterPro:IPR016185), Biotin carboxylation domain (InterPro:IPR011764), ATP-grasp fold (InterPro:IPR011761), Biotin carboxylase, C-terminal (InterPro:IPR005482), ATP-grasp fold, subdomain 2 (InterPro:IPR013816), Pre-ATP-grasp fold (InterPro:IPR013817), Rudiment single hybrid motif (InterPro:IPR011054); BEST Arabidopsis thaliana protein match is: methylcrotonyl-CoA carboxylase alpha chain, mitochondrial / 3-methylcrotonyl-CoA carboxylase 1 (MCCA) (TAIR:AT1G03090.2).
    NP_198386.1
    • acetyl Co-enzyme a carboxylase biotin carboxylase subunit (CAC2); FUNCTIONS IN: biotin carboxylase activity, acetyl-CoA carboxylase activity; INVOLVED IN: fatty acid biosynthetic process; LOCATED IN: chloroplast, chloroplast stroma, chloroplast envelope; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Carbamoyl phosphate synthase, large subunit, N-terminal (InterPro:IPR005481), Carbamoyl phosphate synthetase, large subunit, ATP-binding (InterPro:IPR005479), Acetyl-CoA carboxylase, biotin carboxylase (InterPro:IPR004549), PreATP-grasp-like fold (InterPro:IPR016185), Biotin carboxylation domain (InterPro:IPR011764), ATP-grasp fold (InterPro:IPR011761), Biotin carboxylase, C-terminal (InterPro:IPR005482), ATP-grasp fold, subdomain 2 (InterPro:IPR013816), Pre-ATP-grasp fold (InterPro:IPR013817), Rudiment single hybrid motif (InterPro:IPR011054); BEST Arabidopsis thaliana protein match is: methylcrotonyl-CoA carboxylase alpha chain, mitochondrial / 3-methylcrotonyl-CoA carboxylase 1 (MCCA) (TAIR:AT1G03090.2); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      13584104..13588496
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_122927.4 → NP_198386.1  acetyl Co-enzyme a carboxylase biotin carboxylase subunit [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_198386.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04983, P93650, Q9C5F8
      UniProtKB/TrEMBL
      A0A178U9M2, A0A654G590
      Conserved Domains (1) summary
      TIGR00514
      Location:73 → 521
      accC; acetyl-CoA carboxylase, biotin carboxylase subunit

    2. NM_001203493.1 → NP_001190422.1  acetyl Co-enzyme a carboxylase biotin carboxylase subunit [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190422.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UBV9, F4JYE0
      Conserved Domains (4) summary
      TIGR00514
      Location:73 → 521
      accC; acetyl-CoA carboxylase, biotin carboxylase subunit
      pfam00289
      Location:75 → 182
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam02785
      Location:408 → 513
      Biotin_carb_C; Biotin carboxylase C-terminal domain
      pfam02786
      Location:187 → 394
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

    3. NM_001036891.2 → NP_001031968.1  acetyl Co-enzyme a carboxylase biotin carboxylase subunit [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031968.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UBV9, F4JYE1
      Conserved Domains (4) summary
      PRK08591
      Location:75 → 490
      PRK08591; acetyl-CoA carboxylase biotin carboxylase subunit; Validated
      pfam00289
      Location:75 → 182
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam02785
      Location:408 → 490
      Biotin_carb_C; Biotin carboxylase C-terminal domain
      pfam02786
      Location:187 → 394
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O04983.1

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