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    gshA glutamate--cysteine ligase [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 879474, updated on 11-Sep-2024

    Summary

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    Gene symbol
    gshA
    Gene description
    glutamate--cysteine ligase
    Locus tag
    PA5203
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (5856532..5858115)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene N-acetylglutamate synthase Neighboring gene multiple drug resistance protein MarC Neighboring gene acetylornithine deacetylase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pseudomonas aeruginosa gshA Mutant Is Defective in Biofilm Formation, Swarming, and Pyocyanin Production. Van Laar TA, et al. mSphere, 2018 Apr 25. PMID 29669887, Free PMC Article
    2. On the active site thiol of gamma-glutamylcysteine synthetase: relationships to catalysis, inhibition, and regulation. Huang CS, et al. Proc Natl Acad Sci U S A, 1988 Apr. PMID 2895925, Free PMC Article
    3. Pseudomonas aeruginosa glutathione biosynthesis genes play multiple roles in stress protection, bacterial virulence and biofilm formation. Wongsaroj L, et al. PLoS One, 2018. PMID 30325949, Free PMC Article
    4. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article
    5. Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. Cirz RT, et al. J Bacteriol, 2006 Oct. PMID 17015649, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. glutathione product and the genes responsible for glutathione synthesis play multiple crucial roles in oxidative stress protection, bacterial virulence and biofilm formation in P. aeruginosa
      Title: Pseudomonas aeruginosa glutathione biosynthesis genes play multiple roles in stress protection, bacterial virulence and biofilm formation.
    2. gshA mutant was defective in biofilm and persister cell formation and in swimming and swarming motility and produced reduced levels of pyocyanin, a key virulence factor.
      Title: Pseudomonas aeruginosa gshA Mutant Is Defective in Biofilm Formation, Swarming, and Pyocyanin Production.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Function Evidence Code Pubs
    enables glutamate-cysteine ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within glutathione biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glutamate--cysteine ligase
    NP_253890.1
    • Product name confidence: class 2 (High similarity to functionally studied protein)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      5856532..5858115
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_253890.1 glutamate--cysteine ligase [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_253890.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9HTY6
      Conserved Domains (1) summary
      PRK02107
      Location:24 → 522
      PRK02107; glutamate--cysteine ligase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9HTY6.1

    Gene LinkOut

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