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    RAB22A RAB22A, member RAS oncogene family [ Homo sapiens (human) ]

    Gene ID: 57403, updated on 4-Jan-2025

    Summary

    Official Symbol
    RAB22Aprovided by HGNC
    Official Full Name
    RAB22A, member RAS oncogene familyprovided by HGNC
    Primary source
    HGNC:HGNC:9764
    See related
    Ensembl:ENSG00000124209 MIM:612966; AllianceGenome:HGNC:9764
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene is a member of the RAB family of small GTPases. The GTP-bound form of the encoded protein has been shown to interact with early-endosomal antigen 1, and may be involved in the trafficking of and interaction between endosomal compartments. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 7.8), adrenal (RPKM 6.5) and 25 other tissues See more
    Orthologs
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    Genomic context

    See RAB22A in Genome Data Viewer
    Location:
    20q13.32
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (58309715..58367507)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (60090659..60148468)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (56884771..56942563)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13069 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:56816520-56817020 Neighboring gene ankyrin repeat domain 60 Neighboring gene protein phosphatase 4 regulatory subunit 1 like (pseudogene) Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56877500-56878000 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13070 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13071 Neighboring gene NANOG hESC enhancer GRCh37_chr20:56947914-56948415 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13073 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13072 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:56988153-56988944 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:56988945-56989734 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr20:57002581-57003275 Neighboring gene VAMP associated protein B and C Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:57021533-57022034 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18173 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18174 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:57035877-57036065 Neighboring gene APC down-regulated 1 like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:57089058-57090056 Neighboring gene APCDD1L divergent transcript

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Clone Names

    • MGC16770

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GDP binding PubMed 
    enables GTP binding PubMed 
    enables GTPase activity  
    enables GTPase activity PubMed 
    enables GTPase activity PubMed 
    enables protein binding PubMed 
    Process Evidence Code Pubs
    involved_in endocytosis  
    involved_in endocytosis PubMed 
    involved_in endosome organization PubMed 
    involved_in intracellular protein transport  
    involved_in regulation of vesicle size PubMed 
    Component Evidence Code Pubs
    located_in actin cytoskeleton  
    is_active_in early endosome  
    located_in early endosome PubMed 
    is_active_in endomembrane system  
    located_in endosome membrane  
    located_in extracellular exosome PubMed 
    located_in late endosome  
    located_in phagocytic vesicle PubMed 
    located_in phagocytic vesicle membrane  
    located_in plasma membrane PubMed 
    located_in ruffle  

    General protein information

    Preferred Names
    ras-related protein Rab-22A
    Names
    GTP-binding protein RAB22A
    rab-22
    NP_065724.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020673.3 → NP_065724.1  ras-related protein Rab-22A

      See identical proteins and their annotated locations for NP_065724.1

      Status: REVIEWED

      Source sequence(s)
      AL035455, BC015710, BC042545, DB452461
      Consensus CDS
      CCDS33497.1
      UniProtKB/Swiss-Prot
      B3KR86, E1P605, Q8TF12, Q9H4E6, Q9UL26
      Related
      ENSP00000244040.3, ENST00000244040.4
      Conserved Domains (1) summary
      cd01860
      Location:5 → 167
      Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      58309715..58367507
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      60090659..60148468
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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