Psma4 proteasome subunit alpha 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Psma4provided by MGI
Official Full Name: proteasome subunit alpha 4provided by MGI
Primary source: MGI:MGI:1347060
See related: Ensembl:ENSMUSG00000032301 AllianceGenome:MGI:1347060
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: C9
Summary: Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in P-body. Part of proteasome core complex. Is expressed in liver. Orthologous to human PSMA4 (proteasome 20S subunit alpha 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 71.5), CNS E11.5 (RPKM 59.3) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 B; 9 29.84 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (54858074..54865316)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (54950781..54958034)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Islr regulates insulin sensitivity by interacting with Psma4 to control insulin receptor alpha levels in obese mice.
Title: Islr regulates insulin sensitivity by interacting with Psma4 to control insulin receptor alpha levels in obese mice.
Proteasome subunit alpha4s is essential for formation of spermatoproteasomes and histone degradation during meiotic DNA repair in spermatocytes.
Title: Proteasome subunit α4s is essential for formation of spermatoproteasomes and histone degradation during meiotic DNA repair in spermatocytes.
Data indicate that proteasome subunit alpha4 (alpha4s) is exclusively expressed in germ cells that enter the meiotic prophase.
Title: Characterization of the testis-specific proteasome subunit α4s in mammals.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:492304

AY074887 (e-PCR), detects polymorphism
- UniSTS:516121

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in P-body	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
part_of proteasome complex	ISO Inferred from Sequence Orthology more info
part_of proteasome core complex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome core complex	ISO Inferred from Sequence Orthology more info
part_of proteasome core complex, alpha-subunit complex	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome core complex, alpha-subunit complex	ISO Inferred from Sequence Orthology more info
part_of proteasome core complex, alpha-subunit complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: proteasome subunit alpha type-4

Names: alpha-3; macropain subunit C9; multicatalytic endopeptidase complex subunit C9; proteasome (prosome, macropain) subunit, alpha type 4; proteasome component C9; proteasome subunit L; proteasome subunit alpha-3

NP_001396620.1

EC 3.4.25.1

NP_001396621.1

EC 3.4.25.1

NP_036096.1

EC 3.4.25.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001409691.1 → NP_001396620.1 proteasome subunit alpha type-4 isoform 1

Status: VALIDATED

Source sequence(s)

AC161264

UniProtKB/Swiss-Prot

Q3THT1, Q9R1P0

Related

ENSMUSP00000126844.2, ENSMUST00000172407.8
NM_001409692.1 → NP_001396621.1 proteasome subunit alpha type-4 isoform 2

Status: VALIDATED

Source sequence(s)

AC161264
NM_011966.4 → NP_036096.1 proteasome subunit alpha type-4 isoform 1

See identical proteins and their annotated locations for NP_036096.1

Status: VALIDATED

Source sequence(s)

AC161264

Consensus CDS

CCDS40643.1

UniProtKB/Swiss-Prot

Q3THT1, Q9R1P0

UniProtKB/TrEMBL

Q3TL95

Related

ENSMUSP00000034848.8, ENSMUST00000034848.14

Conserved Domains (1) summary

cd03752
Location:3 → 216

proteasome_alpha_type_4; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...