Ap1m2 adaptor protein complex AP-1, mu 2 subunit [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ap1m2provided by MGI
Official Full Name: adaptor protein complex AP-1, mu 2 subunitprovided by MGI
Primary source: MGI:MGI:1336974
See related: Ensembl:ENSMUSG00000003309 AllianceGenome:MGI:1336974
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mu1B; [m]1B; D9Ertd818e
Summary: Predicted to enable clathrin adaptor activity. Predicted to be involved in vesicle-mediated transport. Predicted to act upstream of or within intracellular protein transport. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be active in clathrin-coated vesicle. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and skin. Orthologous to human AP1M2 (adaptor related protein complex 1 subunit mu 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in large intestine adult (RPKM 27.8), colon adult (RPKM 22.4) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A3; 9 7.76 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (21206753..21223617, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (21294615..21312349, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AP-1B regulates interactions of epithelial cells and intraepithelial lymphocytes in the intestine.
Title: AP-1B regulates interactions of epithelial cells and intraepithelial lymphocytes in the intestine.
Intestinal epithelium dysfunctions cause IgA deposition in the kidney glomeruli of intestine-specific Ap1m2-deficient mice.
Title: Intestinal epithelium dysfunctions cause IgA deposition in the kidney glomeruli of intestine-specific Ap1m2-deficient mice.
AP-1B is required for protein sorting and polarization of intestinal cells in mice. Loss of AP-1B in the intestinal epithelia results in mislocalization of E-cadherin, activation of beta-catenin/Tcf4 complex, proliferation, and hyperplasia.
Title: AP-1B-mediated protein sorting regulates polarity and proliferation of intestinal epithelial cells in mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

General gene information

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Markers

D9Ertd818e (e-PCR), detects polymorphism
- UniSTS:167632

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables clathrin adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in basolateral protein secretion	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within intracellular protein transport	TAS Traceable Author Statement more info	PubMed
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within vesicle-mediated transport	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of AP-1 adaptor complex	NAS Non-traceable Author Statement more info	PubMed
is_active_in clathrin-coated vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	TAS Traceable Author Statement more info	PubMed
located_in trans-Golgi network membrane	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: AP-1 complex subunit mu-2

Names: AP-mu chain family member mu1B; adaptor protein complex AP-1 subunit mu-2; adaptor-related protein complex 1 mu-2 subunit; adaptor-related protein complex 1 subunit mu-2; adaptor-related protein complex AP-1, mu 2 subunit; clathrin assembly protein complex 1 medium chain 2; clathrin assembly protein complex 1 mu-2 medium chain 2; golgi adaptor HA1/AP1 adaptin mu-2 subunit; mu-adaptin 2; mu1B-adaptin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110300.2 → NP_001103770.1 AP-1 complex subunit mu-2 isoform 1

See identical proteins and their annotated locations for NP_001103770.1

Status: VALIDATED

Source sequence(s)

AC122525

Consensus CDS

CCDS52734.1

UniProtKB/Swiss-Prot

Q99LA4, Q9CWP7, Q9WVP1

UniProtKB/TrEMBL

A0A0R4J1L4

Related

ENSMUSP00000111093.4, ENSMUST00000115433.11

Conserved Domains (2) summary

cd14835
Location:4 → 142

AP1_Mu_N; AP-1 complex subunit mu N-terminal domain

cl10970
Location:154 → 423

AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
NM_001410422.1 → NP_001397351.1 AP-1 complex subunit mu-2 isoform 3

Status: VALIDATED

Source sequence(s)

AC122525
NM_001410423.1 → NP_001397352.1 AP-1 complex subunit mu-2 isoform 4

Status: VALIDATED

Source sequence(s)

AC122525
NM_009678.3 → NP_033808.2 AP-1 complex subunit mu-2 isoform 2

See identical proteins and their annotated locations for NP_033808.2

Status: VALIDATED

Source sequence(s)

AC122525

Consensus CDS

CCDS22902.1

UniProtKB/Swiss-Prot

Q99LA4, Q9CWP7, Q9WVP1

UniProtKB/TrEMBL

A0A0R4IZX6

Related

ENSMUSP00000003397.8, ENSMUST00000003397.9

Conserved Domains (2) summary

cd14835
Location:4 → 142

AP1_Mu_N; AP-1 complex subunit mu N-terminal domain

cl10970
Location:154 → 421

AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)