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    Krt85 keratin 85 [ Mus musculus (house mouse) ]

    Gene ID: 53622, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Krt85provided by MGI
    Official Full Name
    keratin 85provided by MGI
    Primary source
    MGI:MGI:1859268
    See related
    Ensembl:ENSMUSG00000116336 AllianceGenome:MGI:1859268
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hb5; Gm49425; Krt2-18
    Summary
    Predicted to be a structural constituent of skin epidermis. Predicted to be involved in intermediate filament organization and keratinization. Predicted to be active in keratin filament. Is expressed in skin. Human ortholog(s) of this gene implicated in ectodermal dysplasia 4. Orthologous to human KRT85 (keratin 85). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See Krt85 in Genome Data Viewer
    Location:
    15 F2; 15
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (101413569..101422054, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:101316581-101316768 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:101316810-101316963 Neighboring gene keratin 83 Neighboring gene STARR-seq mESC enhancer starr_39797 Neighboring gene STARR-seq mESC enhancer starr_39798 Neighboring gene type II keratin Kb32P Neighboring gene predicted gene, 53914 Neighboring gene STARR-seq mESC enhancer starr_39799 Neighboring gene keratin 84 Neighboring gene keratin 82

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000081.7 Chromosome 15 Reference GRCm39 C57BL/6J

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene. Mikula M, et al. EMBO J, 2001 Apr 17. PMID 11296228, Free PMC Article
    2. Cytokeratin, vimentin and E-cadherin immunodetection in the embryonic palate in two strains of mice with different susceptibility to glucocorticoid-induced clefting. Montenegro MA, et al. J Craniofac Genet Dev Biol, 2000 Jul-Sep. PMID 11321598
    3. Sox13 is a novel early marker for hair follicle development. Noto M, et al. Biochem Biophys Res Commun, 2019 Feb 19. PMID 30638933
    4. Dlx3 is a crucial regulator of hair follicle differentiation and cycling. Hwang J, et al. Development, 2008 Sep. PMID 18684741, Free PMC Article
    5. Deletion of the epidermis derived laminin γ1 chain leads to defects in the regulation of late hair morphogenesis. Fleger-Weckmann A, et al. Matrix Biol, 2016 Dec. PMID 27234308

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural constituent of skin epidermis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in keratinization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in keratin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in keratin filament IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    keratin, type II cuticular Hb5
    Names
    K85
    keratin complex 2, basic, gene 18
    type II hair keratin Hb5
    type-II keratin Kb25

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016879.3 → NP_058575.2  keratin, type II cuticular Hb5

      See identical proteins and their annotated locations for NP_058575.2

      Status: PROVISIONAL

      Source sequence(s)
      MH371176
      UniProtKB/Swiss-Prot
      Q8CE83, Q9D7M4, Q9Z2T6
      Related
      ENSMUSP00000155398.3, ENSMUST00000230067.3
      Conserved Domains (3) summary
      pfam00038
      Location:122 → 433
      Filament; Intermediate filament protein
      pfam16208
      Location:17 → 119
      Keratin_2_head; Keratin type II head
      cl23720
      Location:332 → 400
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      101413569..101422054 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z2T6.2 GenPept UniProtKB/Swiss-Prot:Q9Z2T6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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