Klhdc3 kelch domain containing 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Klhdc3provided by MGI
Official Full Name: kelch domain containing 3provided by MGI
Primary source: MGI:MGI:2651568
See related: Ensembl:ENSMUSG00000063576 AllianceGenome:MGI:2651568
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Peas; 1300011D16Rik
Summary: Predicted to enable chromatin binding activity and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Located in chromatin and cytoplasm. Orthologous to human KLHDC3 (kelch domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in testis adult (RPKM 250.5), cortex adult (RPKM 57.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 22.9 cM; 17 C

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (46985476..46991856, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (46674550..46680930, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CRL2-KLHDC3 E3 ubiquitin ligase complex suppresses ferroptosis through promoting p14(ARF) degradation.
Title: CRL2-KLHDC3 E3 ubiquitin ligase complex suppresses ferroptosis through promoting p14(ARF) degradation.
cloned human and mouse Peas cDNAs (hPEAS/mPeas) and analyzed their tissue and stage-specific expressions; may be involved in meiotic recombination process
Title: A novel testis-specific RAG2-like protein, Peas: its expression in pachytene spermatocyte cytoplasm and meiotic chromatin.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin-like ligase-substrate adaptor activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-like ligase-substrate adaptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Cul2-RING ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of Cul2-RING ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in chromatin	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: kelch domain-containing protein 3

Names: protein Peas; testis intracellular mediator protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163729.2 → NP_001157201.2 kelch domain-containing protein 3

See identical proteins and their annotated locations for NP_001157201.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AK079082, AK141673, BY606590, CT030702

Consensus CDS

CCDS28834.1

UniProtKB/Swiss-Prot

Q3TCN9, Q3UR95, Q8VEM9, Q91XU6, Q99JH9, Q9DBG8

UniProtKB/TrEMBL

A0A0R4J0W0

Related

ENSMUSP00000128271.2, ENSMUST00000165007.9

Conserved Domains (3) summary

PLN02153
Location:74 → 318

PLN02153; epithiospecifier protein

sd00038
Location:128 → 173

Kelch; KELCH repeat [structural motif]

pfam13964
Location:14 → 61

Kelch_6; Kelch motif
NM_027910.3 → NP_082186.2 kelch domain-containing protein 3

See identical proteins and their annotated locations for NP_082186.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AK004964, AK141673, BE945284, CF169399

Consensus CDS

CCDS28834.1

UniProtKB/Swiss-Prot

Q3TCN9, Q3UR95, Q8VEM9, Q91XU6, Q99JH9, Q9DBG8

UniProtKB/TrEMBL

A0A0R4J0W0

Related

ENSMUSP00000071743.6, ENSMUST00000071841.7

Conserved Domains (3) summary

PLN02153
Location:74 → 318

PLN02153; epithiospecifier protein

sd00038
Location:128 → 173

Kelch; KELCH repeat [structural motif]

pfam13964
Location:14 → 61

Kelch_6; Kelch motif

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

46985476..46991856 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006524943.5 → XP_006525006.1 kelch domain-containing protein 3 isoform X1

See identical proteins and their annotated locations for XP_006525006.1

UniProtKB/Swiss-Prot

Q3TCN9, Q3UR95, Q8VEM9, Q91XU6, Q99JH9, Q9DBG8

UniProtKB/TrEMBL

A0A0R4J0W0

Conserved Domains (3) summary

PLN02153
Location:74 → 318

PLN02153; epithiospecifier protein

sd00038
Location:128 → 173

Kelch; KELCH repeat [structural motif]

pfam13964
Location:14 → 61

Kelch_6; Kelch motif