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    Epb41l4b erythrocyte membrane protein band 4.1 like 4b [ Mus musculus (house mouse) ]

    Gene ID: 54357, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Epb41l4bprovided by MGI
    Official Full Name
    erythrocyte membrane protein band 4.1 like 4bprovided by MGI
    Primary source
    MGI:MGI:1859149
    See related
    Ensembl:ENSMUSG00000028434 AllianceGenome:MGI:1859149
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ehm2; Lulu2; Epb4.1l4b; D4Ertd346e; 6430543G08Rik
    Summary
    Predicted to enable cytoskeletal protein binding activity. Predicted to be involved in several processes, including actomyosin structure organization; positive regulation of keratinocyte migration; and wound healing. Predicted to be located in apical part of cell; cytosol; and plasma membrane. Predicted to be active in cytoskeleton. Is expressed in several structures, including genitourinary system; gut; nervous system; skin; and trachea. Orthologous to human EPB41L4B (erythrocyte membrane protein band 4.1 like 4B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in large intestine adult (RPKM 21.1), colon adult (RPKM 11.0) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Epb41l4b in Genome Data Viewer
    Location:
    4 B3; 4 31.66 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (56991977..57143753, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (56991972..57143168, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 245 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:56928950-56929103 Neighboring gene STARR-seq mESC enhancer starr_10314 Neighboring gene predicted gene, 22300 Neighboring gene STARR-seq mESC enhancer starr_10316 Neighboring gene ferric-chelate reductase 1 like Neighboring gene predicted gene, 34738 Neighboring gene STARR-seq mESC enhancer starr_10320 Neighboring gene predicted gene, 34802 Neighboring gene predicted gene 12530

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of genes differentially expressed in association with metastatic potential of K-1735 murine melanoma by messenger RNA differential display. Hashimoto Y, et al. Cancer Res, 1996 Nov 15. PMID 8912867
    2. Molecular cloning of a novel NF2/ERM/4.1 superfamily gene, ehm2, that is expressed in high-metastatic K1735 murine melanoma cells. Shimizu K, et al. Genomics, 2000 Apr 15. PMID 10783258
    3. Cloning, characterization, and genomic structure of the mouse Ikbkap gene. Cuajungco MP, et al. DNA Cell Biol, 2001 Sep. PMID 11747609
    4. Lulu2 regulates the circumferential actomyosin tensile system in epithelial cells through p114RhoGEF. Nakajima H, et al. J Cell Biol, 2011 Oct 17. PMID 22006950, Free PMC Article
    5. Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome. Unda BK, et al. Mol Psychiatry, 2023 Apr. PMID 36604605, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytoskeletal protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actomyosin structure organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within actomyosin structure organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of keratinocyte migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in wound healing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical part of cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    band 4.1-like protein 4B
    Names
    erythrocyte protein band 4.1-like 4b
    erythrocyte protein band 4.1-like 4b; expressed in high-metastatic cells
    expressed in high-metastatic cells

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355492.2 → NP_001342421.1  band 4.1-like protein 4B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL805921, AL831761
      Conserved Domains (3) summary
      smart00295
      Location:87 → 277
      B41; Band 4.1 homologues
      cd13186
      Location:273 → 366
      FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
      pfam08736
      Location:379 → 419
      FA; FERM adjacent (FA)

    2. NM_001424796.1 → NP_001411725.1  band 4.1-like protein 4B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL805921, AL831761

    3. NM_019427.3 → NP_062300.2  band 4.1-like protein 4B isoform 1

      See identical proteins and their annotated locations for NP_062300.2

      Status: VALIDATED

      Source sequence(s)
      AL805921, AL831761
      Consensus CDS
      CCDS51180.1
      UniProtKB/Swiss-Prot
      A2ALK7, Q9JMC8
      UniProtKB/TrEMBL
      Q3TMR3
      Related
      ENSMUSP00000030142.4, ENSMUST00000030142.4
      Conserved Domains (5) summary
      smart00295
      Location:87 → 277
      B41; Band 4.1 homologues
      cd13186
      Location:273 → 366
      FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
      pfam00373
      Location:170 → 277
      FERM_M; FERM central domain
      pfam08736
      Location:379 → 419
      FA; FERM adjacent (FA)
      pfam09379
      Location:89 → 151
      FERM_N; FERM N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      56991977..57143753 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164240.1 → XP_036020133.1  band 4.1-like protein 4B isoform X5

      Conserved Domains (2) summary
      pfam08736
      Location:78 → 119
      FA; FERM adjacent (FA)
      cl17171
      Location:10 → 65
      PH-like; Pleckstrin homology-like domain

    2. XM_011250068.2 → XP_011248370.1  band 4.1-like protein 4B isoform X2

      Conserved Domains (3) summary
      smart00295
      Location:87 → 277
      B41; Band 4.1 homologues
      cd13186
      Location:273 → 366
      FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
      pfam08736
      Location:379 → 419
      FA; FERM adjacent (FA)

    3. XM_006538087.4 → XP_006538150.1  band 4.1-like protein 4B isoform X1

      UniProtKB/TrEMBL
      A2ALK6
      Related
      ENSMUSP00000092687.4, ENSMUST00000095076.10
      Conserved Domains (3) summary
      smart00295
      Location:87 → 277
      B41; Band 4.1 homologues
      cd13186
      Location:273 → 366
      FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
      pfam08736
      Location:379 → 419
      FA; FERM adjacent (FA)

    4. XM_006538089.5 → XP_006538152.1  band 4.1-like protein 4B isoform X4

      Conserved Domains (4) summary
      smart00295
      Location:87 → 277
      B41; Band 4.1 homologues
      pfam06495
      Location:332 → 498
      Transformer; Fruit fly transformer protein
      cd13186
      Location:273 → 366
      FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
      pfam08736
      Location:379 → 419
      FA; FERM adjacent (FA)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JMC8.2 GenPept UniProtKB/Swiss-Prot:Q9JMC8

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