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    Tmem138 transmembrane protein 138 [ Mus musculus (house mouse) ]

    Gene ID: 72982, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tmem138provided by MGI
    Official Full Name
    transmembrane protein 138provided by MGI
    Primary source
    MGI:MGI:1920232
    See related
    Ensembl:ENSMUSG00000024666 AllianceGenome:MGI:1920232
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700113I01Rik; 2900055D14Rik
    Summary
    Predicted to be involved in cilium assembly. Predicted to be located in vacuolar membrane. Predicted to be active in cilium. Is expressed in several structures, including 4th ventricle choroid plexus; brain ventricular layer; choroid invagination; genitourinary system; and gut gland. Human ortholog(s) of this gene implicated in Joubert syndrome 16. Orthologous to human TMEM138 (transmembrane protein 138). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 6.9), CNS E11.5 (RPKM 6.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem138 in Genome Data Viewer
    Location:
    19 A; 19 6.6 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (10547842..10554765, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (10570478..10577386, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene succinate dehydrogenase complex assembly factor 2 Neighboring gene cleavage and polyadenylation specific factor 7 Neighboring gene transmembrane protein 216 Neighboring gene STARR-positive B cell enhancer ABC_E9455 Neighboring gene cytochrome b561 family, member A3 Neighboring gene STARR-positive B cell enhancer ABC_E5687 Neighboring gene triokinase, FMN cyclase Neighboring gene damage specific DNA binding protein 1 Neighboring gene RIKEN cDNA 4930524O05 gene Neighboring gene von Willebrand factor C and EGF domains

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    2. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC129472

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 138

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302218.1 → NP_001289147.1  transmembrane protein 138 isoform 2

      See identical proteins and their annotated locations for NP_001289147.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a downstream alternate 5'-terminal exon and includes an upstream alternate 3' terminal exon, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC125093, AK007197
      UniProtKB/Swiss-Prot
      Q9D6G5
      Related
      ENSMUST00000236958.2
      Conserved Domains (1) summary
      pfam14935
      Location:38 → 100
      TMEM138; Transmembrane protein 138

    2. NM_028411.4 → NP_082687.1  transmembrane protein 138 isoform 1

      See identical proteins and their annotated locations for NP_082687.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA030680, AC125093, AK031921, AK050471
      Consensus CDS
      CCDS29581.1
      UniProtKB/Swiss-Prot
      Q9D6G5, Q9D9A8
      Related
      ENSMUSP00000025568.3, ENSMUST00000025568.3
      Conserved Domains (1) summary
      pfam14935
      Location:38 → 156
      TMEM138; Transmembrane protein 138

    RNA

    1. NR_126092.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the central region, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AA030680, AC125093, AK031921, AK050471
      Related
      ENSMUST00000235990.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      10547842..10554765 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247366.3 → XP_011245668.1  transmembrane protein 138 isoform X1

      See identical proteins and their annotated locations for XP_011245668.1

      UniProtKB/Swiss-Prot
      Q9D6G5, Q9D9A8
      Related
      ENSMUSP00000157715.2, ENSMUST00000236099.2
      Conserved Domains (1) summary
      pfam14935
      Location:38 → 156
      TMEM138; Transmembrane protein 138

    2. XM_011247367.3 → XP_011245669.1  transmembrane protein 138 isoform X1

      See identical proteins and their annotated locations for XP_011245669.1

      UniProtKB/Swiss-Prot
      Q9D6G5, Q9D9A8
      Conserved Domains (1) summary
      pfam14935
      Location:38 → 156
      TMEM138; Transmembrane protein 138

    3. XM_036161700.1 → XP_036017593.1  transmembrane protein 138 isoform X2

      Conserved Domains (1) summary
      pfam14935
      Location:38 → 101
      TMEM138; Transmembrane protein 138
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D6G5.1 GenPept UniProtKB/Swiss-Prot:Q9D6G5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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