Grk2 G protein-coupled receptor kinase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Grk2provided by MGI
Official Full Name: G protein-coupled receptor kinase 2provided by MGI
Primary source: MGI:MGI:87940
See related: Ensembl:ENSMUSG00000024858 AllianceGenome:MGI:87940
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Adrbk1; Bark-1; Adrbk-1; beta ARK; betaARK1
Summary: Enables G protein-coupled receptor kinase activity. Involved in negative regulation of relaxation of smooth muscle. Acts upstream of or within several processes, including desensitization of G protein-coupled receptor signaling pathway; protein phosphorylation; and regulation of the force of heart contraction. Located in membrane. Is expressed in several structures, including central nervous system; genitourinary system; heart; limb; and mesenchyme derived from neural crest. Orthologous to human GRK2 (G protein-coupled receptor kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in spleen adult (RPKM 143.0), thymus adult (RPKM 142.5) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 3.98 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (4336029..4356356, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (4285999..4306222, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GRK2 kinases in the primary cilium initiate SMOOTHENED-PKA signaling in the Hedgehog cascade.
Title: GRK2 kinases in the primary cilium initiate SMOOTHENED-PKA signaling in the Hedgehog cascade.
GRK2-YAP signaling is implicated in pulmonary arterial hypertension development.
Title: GRK2-YAP signaling is implicated in pulmonary arterial hypertension development.
Hepatic GRK2 is dispensable for glucose homeostasis and other key metabolic parameters in mice.
Title: Hepatic GRK2 is dispensable for glucose homeostasis and other key metabolic parameters in mice.
Overexpression of GRK2 in vascular smooth muscle leads to inappropriate hypertension and acute heart failure as in clinical scenario 1.
Title: Overexpression of GRK2 in vascular smooth muscle leads to inappropriate hypertension and acute heart failure as in clinical scenario 1.
CXCL9, 10, 11/CXCR3 Axis Contributes to the Progress of Primary Sjogren's Syndrome by Activating GRK2 to Promote T Lymphocyte Migration.
Title: CXCL9, 10, 11/CXCR3 Axis Contributes to the Progress of Primary Sjogren's Syndrome by Activating GRK2 to Promote T Lymphocyte Migration.
GRK2 differentially regulates FcepsilonRI and MRGPRB2-mediated responses in mast cells.
Title: GRK2 differentially regulates FcεRI and MRGPRB2-mediated responses in mast cells.
Gender differences in GRK2 in cardiovascular diseases and its interactions with estrogen.
Title: Gender differences in GRK2 in cardiovascular diseases and its interactions with estrogen.
Endothelin receptor B enhances liver injury and pro-inflammatory responses by increasing G-protein-coupled receptor kinase-2 expression in primary biliary cholangitis.
Title: Endothelin receptor B enhances liver injury and pro-inflammatory responses by increasing G-protein-coupled receptor kinase-2 expression in primary biliary cholangitis.
The tyrosine phosphorylation of GRK2 is responsible for activated D2R-mediated insulin resistance.
Title: The tyrosine phosphorylation of GRK2 is responsible for activated D(2)R-mediated insulin resistance.
GRK2 regulates group 2 innate lymphoid cell mobilization in sepsis.
Title: GRK2 regulates group 2 innate lymphoid cell mobilization in sepsis.

Submit: New GeneRIF Correction See all GeneRIFs (124)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Adrbk1 (e-PCR), detects polymorphism
- UniSTS:527241

RH94463 (e-PCR)
- UniSTS:119711

D1Bda45 (e-PCR)
- UniSTS:239792

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables Edg-2 lysophosphatidic acid receptor binding	IEA Inferred from Electronic Annotation more info
enables Edg-2 lysophosphatidic acid receptor binding	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor binding	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled receptor kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables G protein-coupled receptor kinase activity	ISO Inferred from Sequence Orthology more info
enables beta-adrenergic receptor kinase activity	IEA Inferred from Electronic Annotation more info
enables beta-adrenergic receptor kinase activity	ISO Inferred from Sequence Orthology more info
enables delta-type opioid receptor binding	ISO Inferred from Sequence Orthology more info
enables kappa-type opioid receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in cardiac muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in cellular response to chemokine	ISO Inferred from Sequence Orthology more info
involved_in cellular response to epidermal growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in desensitization of G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within desensitization of G protein-coupled receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within desensitization of G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in desensitization of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in follicle-stimulating hormone signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of protein location in nucleus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of D-glucose import	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of relaxation of smooth muscle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of relaxation of smooth muscle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of striated muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of striated muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of the force of heart contraction by chemical signal	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of the force of heart contraction by chemical signal	ISO Inferred from Sequence Orthology more info
involved_in oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within peptidyl-threonine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of catecholamine secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vasoconstriction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in receptor internalization	IEA Inferred from Electronic Annotation more info
involved_in receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in regulation of the force of heart contraction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of the force of heart contraction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
involved_in response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in symbiont entry into host cell	IEA Inferred from Electronic Annotation more info
involved_in symbiont entry into host cell	ISO Inferred from Sequence Orthology more info
involved_in tachykinin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in tachykinin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in vasodilation	ISO Inferred from Sequence Orthology more info
involved_in viral genome replication	IEA Inferred from Electronic Annotation more info
involved_in viral genome replication	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in caveola	ISO Inferred from Sequence Orthology more info
located_in cilium	TAS Traceable Author Statement more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in dendritic shaft	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in presynapse	IEA Inferred from Electronic Annotation more info
is_active_in presynapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: beta-adrenergic receptor kinase 1

Names: adrenergic receptor kinase, beta 1; beta-AR kinase-1

NP_001277747.1

EC 2.7.11.15

NP_001412806.1

EC 2.7.11.15

NP_570933.1

EC 2.7.11.15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290818.2 → NP_001277747.1 beta-adrenergic receptor kinase 1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).

Source sequence(s)

AC140073

Consensus CDS

CCDS70915.1

UniProtKB/Swiss-Prot

Q99LL8, Q99MK8

UniProtKB/TrEMBL

Q3U1V3

Related

ENSMUSP00000086114.5, ENSMUST00000088737.11

Conserved Domains (5) summary

cd08747
Location:30 → 186

RGS_GRK2_GRK3; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 2 (GRK2) and G protein-coupled receptor kinase 3 (GRK3)

cd01240
Location:553 → 670

PH_GRK2_subgroup; G Protein-Coupled Receptor Kinase 2 subgroup pleckstrin homology (PH) domain

cd14223
Location:190 → 510

STKc_GRK2; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 2

pfam00069
Location:191 → 453

Pkinase; Protein kinase domain

pfam00169
Location:562 → 650

PH; PH domain
NM_001425877.1 → NP_001412806.1 beta-adrenergic receptor kinase 1 isoform 3

Status: VALIDATED

Source sequence(s)

AC140073

Related

ENSMUST00000113837.9
NM_130863.3 → NP_570933.1 beta-adrenergic receptor kinase 1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate exon in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.

Source sequence(s)

AC140073

Consensus CDS

CCDS29426.1

UniProtKB/TrEMBL

Q7TS64

Related

ENSMUSP00000025791.6, ENSMUST00000025791.12

Conserved Domains (5) summary

cd08747
Location:1 → 144

RGS_GRK2_GRK3; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 2 (GRK2) and G protein-coupled receptor kinase 3 (GRK3)

cd01240
Location:511 → 628

PH_GRK2_subgroup; G Protein-Coupled Receptor Kinase 2 subgroup pleckstrin homology (PH) domain

cd14223
Location:148 → 468

STKc_GRK2; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 2

pfam00069
Location:149 → 411

Pkinase; Protein kinase domain

pfam00169
Location:520 → 608

PH; PH domain