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    Spcs2 signal peptidase complex subunit 2 homolog (S. cerevisiae) [ Mus musculus (house mouse) ]

    Gene ID: 66624, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Spcs2provided by MGI
    Official Full Name
    signal peptidase complex subunit 2 homolog (S. cerevisiae)provided by MGI
    Primary source
    MGI:MGI:1913874
    See related
    Ensembl:ENSMUSG00000035227 AllianceGenome:MGI:1913874
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0102; 5730406I15Rik
    Summary
    Predicted to be involved in protein targeting to ER and signal peptide processing. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of signal peptidase complex. Is expressed in several structures, including alimentary system; brain; integumental system; respiratory system; and urinary system. Orthologous to human SPCS2 (signal peptidase complex subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 23.9), CNS E11.5 (RPKM 21.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Spcs2 in Genome Data Viewer
    Location:
    7 E1; 7 54.15 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (99486775..99512576, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (99837569..99870340, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 2 subfamily AT member 1 Neighboring gene olfactory receptor enhancer Ikaria Neighboring gene STARR-positive B cell enhancer ABC_E3735 Neighboring gene STARR-seq mESC enhancer starr_19662 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:106976805-106976914 Neighboring gene STARR-positive B cell enhancer ABC_E3736 Neighboring gene neuraminidase 3 Neighboring gene STARR-positive B cell enhancer ABC_E1347 Neighboring gene X-ray radiation resistance associated 1 Neighboring gene predicted gene, 38405 Neighboring gene ring finger protein 169 Neighboring gene predicted gene 5115

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    2. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    3. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    4. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
    5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC60452

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in protein targeting to ER IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal peptide processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal peptide processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal peptide processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of signal peptidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of signal peptidase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of signal peptidase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    signal peptidase complex subunit 2
    Names
    SPase 25 kDa subunit
    microsomal signal peptidase 25 kDa subunit
    NP_001405668.1
    NP_079944.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418739.1 → NP_001405668.1  signal peptidase complex subunit 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC113298, AC115040
      UniProtKB/TrEMBL
      A0A140LHR3
      Related
      ENSMUSP00000146514.2, ENSMUST00000207063.2

    2. NM_025668.4 → NP_079944.1  signal peptidase complex subunit 2 isoform 1

      See identical proteins and their annotated locations for NP_079944.1

      Status: VALIDATED

      Source sequence(s)
      AC113298, AC115040
      Consensus CDS
      CCDS40033.1
      UniProtKB/Swiss-Prot
      Q3THR2, Q80X74, Q921V8, Q9CXK1, Q9CYN2
      UniProtKB/TrEMBL
      A0A140LHG8
      Related
      ENSMUSP00000041152.7, ENSMUST00000036274.8
      Conserved Domains (1) summary
      pfam06703
      Location:61 → 216
      SPC25; Microsomal signal peptidase 25 kDa subunit (SPC25)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      99486775..99512576 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CYN2.1 GenPept UniProtKB/Swiss-Prot:Q9CYN2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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