Cul1 cullin 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cul1provided by MGI
Official Full Name: cullin 1provided by MGI
Primary source: MGI:MGI:1349658
See related: Ensembl:ENSMUSG00000029686 AllianceGenome:MGI:1349658
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cul-1
Summary: Predicted to enable ubiquitin ligase complex scaffold activity and ubiquitin protein ligase binding activity. Predicted to contribute to ubiquitin protein ligase activity. Involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Acts upstream of or within several processes, including apoptotic process; cell population proliferation; and protein ubiquitination. Part of SCF ubiquitin ligase complex. Is expressed in several structures, including adrenal gland; genitourinary system; immune system; neural retina; and telencephalon. Orthologous to human CUL1 (cullin 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 25.9), bladder adult (RPKM 24.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 B2.3; 6 22.9 cM

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (47430516..47503078)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (47453732..47526144)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CircCUL1 inhibits trophoblast cell migration and invasion and promotes cell autophagy by sponging hsa-miR-30e-3p in fetal growth restriction via the ANXA1/PI3K/AKT axis.
Title: CircCUL1 inhibits trophoblast cell migration and invasion and promotes cell autophagy by sponging hsa-miR-30e-3p in fetal growth restriction via the ANXA1/PI3K/AKT axis.
New insights into the roles of CUL1 in mouse placenta development.
Title: New insights into the roles of CUL1 in mouse placenta development.
REVIEW: comprehensive overview of mouse models and discussion of the role of each CRL1 component in mouse physiology and pathology
Title: Knockout Mouse Models Provide Insight into the Biological Functions of CRL1 Components.
Cul-1 deneddylation led to Deptor accumulation and subsequent mTOR inactivation, which had an inhibitory effect on dendritic cells in mouse model of inflammatory bowel disease.
Title: Inhibition of neddylation regulates dendritic cell functions via Deptor accumulation driven mTOR inactivation.
Lysine 29-linkage of ASK1 by Skp1-Cullin 1-Fbxo21 ubiquitin ligase complex is required for antiviral innate response.
Title: Lys29-linkage of ASK1 by Skp1-Cullin 1-Fbxo21 ubiquitin ligase complex is required for antiviral innate response.
Substrate binding promotes formation of the Skp1-Cul1-Fbxl3 (SCF(Fbxl3)) protein complex.
Title: Substrate binding promotes formation of the Skp1-Cul1-Fbxl3 (SCF(Fbxl3)) protein complex.
Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction.
Title: Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction.
SCCRO recruits Ubc12 approximately NEDD8 to the CAND1-Cul1-ROC1 complex but that this is not sufficient to dissociate or overcome the inhibitory effects of CAND1 on cullin neddylation
Title: SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation.
Analysis of cell cycle regulatory genes reveals defective induction of the c-Myc:CUL1 ubiquitin ligase pathway in B cells from CD22-deficient mice in the context of a C57BL/6 genetic background, following IgM ligation compared with wild-type B cells.
Title: Severely impaired B lymphocyte proliferation, survival, and induction of the c-Myc:Cullin 1 ubiquitin ligase pathway resulting from CD22 deficiency on the C57BL/6 genetic background.
Skp2 and Cul1 expression is repressed by GATA2, thereby inhibiting ubiquitin/proteasome-dependent degradation of p21(WAF1) and p27(Kip1), inducing their accumulation, and suppressing hematopoietic stem cell growth
Title: GATA-2/estrogen receptor chimera regulates cytokine-dependent growth of hematopoietic cells through accumulation of p21(WAF1) and p27(Kip1) proteins.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW743318 (e-PCR)
- UniSTS:207945

D6Mit352 (e-PCR), detects polymorphism
- UniSTS:130903

D6Dcr7 (e-PCR), detects polymorphism
- UniSTS:507762

MHAa27b4.seq (e-PCR)
- UniSTS:125102

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin ligase complex scaffold activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin ligase complex scaffold activity	ISO Inferred from Sequence Orthology more info
contributes_to ubiquitin protein ligase activity	IC Inferred by Curator more info	PubMed
enables ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within animal organ morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein K48-linked ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein K48-linked ubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein monoubiquitination	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	IC Inferred by Curator more info	PubMed

Component	Evidence Code	Pubs
part_of Parkin-FBXW7-Cul1 ubiquitin ligase complex	IEA Inferred from Electronic Annotation more info
part_of Parkin-FBXW7-Cul1 ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of SCF ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SCF ubiquitin ligase complex	IDA Inferred from Direct Assay more info	PubMed
part_of SCF ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of SCF ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
part_of cullin-RING ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: cullin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355550.2 → NP_001342479.1 cullin-1

Status: VALIDATED

Source sequence(s)

AC154014, AC154015

Consensus CDS

CCDS20095.1

UniProtKB/Swiss-Prot

Q9WTX6, Q9WUI7

UniProtKB/TrEMBL

Q3UIA5

Conserved Domains (2) summary

pfam00888
Location:21 → 660

Cullin; Cullin family

pfam10557
Location:706 → 767

Cullin_Nedd8; Cullin protein neddylation domain
NM_001355551.2 → NP_001342480.1 cullin-1

Status: VALIDATED

Source sequence(s)

AC154014, AC154015

Consensus CDS

CCDS20095.1

UniProtKB/Swiss-Prot

Q9WTX6, Q9WUI7

UniProtKB/TrEMBL

Q3UIA5

Related

ENSMUSP00000122702.2, ENSMUST00000146200.8

Conserved Domains (2) summary

pfam00888
Location:21 → 660

Cullin; Cullin family

pfam10557
Location:706 → 767

Cullin_Nedd8; Cullin protein neddylation domain
NM_001410599.1 → NP_001397528.1 cullin-1

Status: VALIDATED

Source sequence(s)

AC154014, AC154015

UniProtKB/Swiss-Prot

Q9WTX6, Q9WUI7
NM_001410600.1 → NP_001397529.1 cullin-1

Status: VALIDATED

Source sequence(s)

AC154014, AC154015

UniProtKB/Swiss-Prot

Q9WTX6, Q9WUI7
NM_001410601.1 → NP_001397530.1 cullin-1

Status: VALIDATED

Source sequence(s)

AC154014, AC154015

UniProtKB/Swiss-Prot

Q9WTX6, Q9WUI7
NM_001410602.1 → NP_001397531.1 cullin-1

Status: VALIDATED

Source sequence(s)

AC154014, AC154015

UniProtKB/Swiss-Prot

Q9WTX6, Q9WUI7
NM_012042.5 → NP_036172.1 cullin-1

See identical proteins and their annotated locations for NP_036172.1

Status: VALIDATED

Source sequence(s)

AC154014, AC154015

Consensus CDS

CCDS20095.1

UniProtKB/Swiss-Prot

Q9WTX6, Q9WUI7

UniProtKB/TrEMBL

Q3UIA5

Related

ENSMUSP00000031697.9, ENSMUST00000031697.9

Conserved Domains (2) summary

pfam00888
Location:21 → 660

Cullin; Cullin family

pfam10557
Location:706 → 767

Cullin_Nedd8; Cullin protein neddylation domain