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    Flrt1 fibronectin leucine rich transmembrane protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 396184, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Flrt1provided by MGI
    Official Full Name
    fibronectin leucine rich transmembrane protein 1provided by MGI
    Primary source
    MGI:MGI:3026647
    See related
    Ensembl:ENSMUSG00000047787 AllianceGenome:MGI:3026647
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D630040I23Rik
    Summary
    Enables fibroblast growth factor receptor binding activity. Involved in dendrite development; fibroblast growth factor receptor signaling pathway; and neuron projection extension. Acts upstream of or within positive regulation of synapse assembly. Located in several cellular components, including neuron projection terminus; neuronal cell body membrane; and perinuclear region of cytoplasm. Colocalizes with focal adhesion. Is expressed in several structures, including embryo mesenchyme; gut; nervous system; neural ectoderm; and sensory organ. Orthologous to human FLRT1 (fibronectin leucine rich transmembrane protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in kidney adult (RPKM 10.2), cortex adult (RPKM 2.7) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Flrt1 in Genome Data Viewer
    Location:
    19 A; 19 5.2 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (7064829..7143548, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (7087464..7166183, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene tRNA phosphotransferase 1 Neighboring gene fermitin family member 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:7092729-7092882 Neighboring gene predicted gene, 54052 Neighboring gene STARR-seq mESC enhancer starr_45447 Neighboring gene stress-induced phosphoprotein 1 Neighboring gene STARR-seq mESC enhancer starr_45448 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:7140992-7141179 Neighboring gene mono-ADP ribosylhydrolase 1 Neighboring gene RIKEN cDNA 5730409K12 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:7190709-7190892 Neighboring gene predicted gene, 38621 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:7238874-7239062 Neighboring gene STARR-positive B cell enhancer ABC_E8735 Neighboring gene OTU domain, ubiquitin aldehyde binding 1 Neighboring gene cytochrome c oxidase subunit 8A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Apicosome: Newly identified cell-type-specific organelle in mouse cochlear and vestibular hair cells. Li X, et al. iScience, 2023 Apr 21. PMID 37123250, Free PMC Article
    2. Critical role of FLRT1 phosphorylation in the interdependent regulation of FLRT1 function and FGF receptor signalling. Wheldon LM, et al. PLoS One, 2010 Apr 22. PMID 20421966, Free PMC Article
    3. FLRT3 Marks Direction-Selective Retinal Ganglion Cells That Project to the Medial Terminal Nucleus. Ruff T, et al. Front Mol Neurosci, 2021. PMID 34955746, Free PMC Article
    4. Structural Basis of Teneurin-Latrophilin Interaction in Repulsive Guidance of Migrating Neurons. Del Toro D, et al. Cell, 2020 Jan 23. PMID 31928845, Free PMC Article
    5. Regulated expression of FLRT genes implies a functional role in the regulation of FGF signalling during mouse development. Haines BP, et al. Dev Biol, 2006 Sep 1. PMID 16872596

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mice with deletions of FLRT1 and FLRT3 adhesion molecules develop macroscopic sulci with preserved layered organization and radial glial morphology. Cortex folding in these mutants does not require progenitor cell amplification but is dependent on changes in neuron migration.
      Title: Regulation of Cerebral Cortex Folding by Controlling Neuronal Migration via FLRT Adhesion Molecules.
    2. FLRT1 is expressed at brain compartmental boundaries in embryo
      Title: Regulated expression of FLRT genes implies a functional role in the regulation of FGF signalling during mouse development.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables fibroblast growth factor receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dendrite development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fibroblast growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron projection extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of synapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with focal adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuron projection terminus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    leucine-rich repeat transmembrane protein FLRT1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201411.2 → NP_958813.1  leucine-rich repeat transmembrane protein FLRT1 precursor

      See identical proteins and their annotated locations for NP_958813.1

      Status: VALIDATED

      Source sequence(s)
      AC109619, AK031503, BE947674
      Consensus CDS
      CCDS29519.1
      UniProtKB/Swiss-Prot
      A0A452J8F8, Q14DT7, Q6RKD8, Q6RKD9
      Related
      ENSMUSP00000109010.3, ENSMUST00000113383.4
      Conserved Domains (4) summary
      PRK15370
      Location:58 → 329
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      TIGR00864
      Location:300 → 406
      PCC; polycystin cation channel protein
      smart00060
      Location:441 → 505
      FN3; Fibronectin type 3 domain
      sd00033
      Location:108 → 128
      LRR_RI; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      7064829..7143548 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527170.4 → XP_006527233.1  leucine-rich repeat transmembrane protein FLRT1 isoform X1

      See identical proteins and their annotated locations for XP_006527233.1

      UniProtKB/Swiss-Prot
      A0A452J8F8, Q14DT7, Q6RKD8, Q6RKD9
      Conserved Domains (4) summary
      PRK15370
      Location:58 → 329
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      TIGR00864
      Location:300 → 406
      PCC; polycystin cation channel protein
      smart00060
      Location:441 → 505
      FN3; Fibronectin type 3 domain
      sd00033
      Location:108 → 128
      LRR_RI; leucine-rich repeat [structural motif]

    2. XM_006527169.3 → XP_006527232.1  leucine-rich repeat transmembrane protein FLRT1 isoform X1

      See identical proteins and their annotated locations for XP_006527232.1

      UniProtKB/Swiss-Prot
      A0A452J8F8, Q14DT7, Q6RKD8, Q6RKD9
      Conserved Domains (4) summary
      PRK15370
      Location:58 → 329
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      TIGR00864
      Location:300 → 406
      PCC; polycystin cation channel protein
      smart00060
      Location:441 → 505
      FN3; Fibronectin type 3 domain
      sd00033
      Location:108 → 128
      LRR_RI; leucine-rich repeat [structural motif]

    3. XM_006527171.5 → XP_006527234.1  leucine-rich repeat transmembrane protein FLRT1 isoform X1

      See identical proteins and their annotated locations for XP_006527234.1

      UniProtKB/Swiss-Prot
      A0A452J8F8, Q14DT7, Q6RKD8, Q6RKD9
      Conserved Domains (4) summary
      PRK15370
      Location:58 → 329
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      TIGR00864
      Location:300 → 406
      PCC; polycystin cation channel protein
      smart00060
      Location:441 → 505
      FN3; Fibronectin type 3 domain
      sd00033
      Location:108 → 128
      LRR_RI; leucine-rich repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6RKD8.3 GenPept UniProtKB/Swiss-Prot:Q6RKD8

    Gene LinkOut

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