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    Dgkb diacylglycerol kinase, beta [ Mus musculus (house mouse) ]

    Gene ID: 217480, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Dgkbprovided by MGI
    Official Full Name
    diacylglycerol kinase, betaprovided by MGI
    Primary source
    MGI:MGI:2442474
    See related
    Ensembl:ENSMUSG00000036095 AllianceGenome:MGI:2442474
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DGK; 90kda; DAGK2; DGK-beta; mKIAA0718; 6430574F24; C630029D13Rik
    Summary
    Enables ATP-dependent diacylglycerol kinase activity. Involved in modulation of chemical synaptic transmission and regulation of postsynapse organization. Acts upstream of or within response to bacterium. Located in plasma membrane. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in anterior abdominal wall musculature; nervous system; retina; and urinary system. Orthologous to human DGKB (diacylglycerol kinase beta). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 12.9), cortex adult (RPKM 7.5) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dgkb in Genome Data Viewer
    Location:
    12 A3; 12 17.11 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (37930169..38684238)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (37880169..38634239)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_31928 Neighboring gene mesenchyme homeobox 2 Neighboring gene alkylglycerol monooxygenase Neighboring gene predicted gene, 34408 Neighboring gene STARR-seq mESC enhancer starr_31930 Neighboring gene STARR-seq mESC enhancer starr_31931 Neighboring gene STARR-seq mESC enhancer starr_31932 Neighboring gene STARR-seq mESC enhancer starr_31933 Neighboring gene STARR-seq mESC enhancer starr_31934 Neighboring gene STARR-seq mESC enhancer starr_31935 Neighboring gene predicted gene, 35755 Neighboring gene predicted gene, 52011 Neighboring gene high mobility group box 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_31936 Neighboring gene RIKEN cDNA 4930428E07 gene Neighboring gene STARR-seq mESC enhancer starr_31937 Neighboring gene STARR-seq mESC enhancer starr_31938 Neighboring gene STARR-seq mESC enhancer starr_31940 Neighboring gene phosphatidylethanolamine binding protein 2 pseudogene Neighboring gene ets variant 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Memantine, an NMDA receptor antagonist, improves working memory deficits in DGKβ knockout mice. Kakefuda K, et al. Neurosci Lett, 2016 Sep 6. PMID 27495014
    2. Involvement of diacylglycerol kinase β in the spine formation at distal dendrites of striatal medium spiny neurons. Hozumi Y, et al. Brain Res, 2015 Jan 12. PMID 25446448
    3. Diacylglycerol kinase β knockout mice exhibit attention-deficit behavior and an abnormal response on methylphenidate-induced hyperactivity. Ishisaka M, et al. PLoS One, 2012. PMID 22590645, Free PMC Article
    4. Essential role of neuron-enriched diacylglycerol kinase (DGK), DGKbeta in neurite spine formation, contributing to cognitive function. Shirai Y, et al. PLoS One, 2010 Jul 15. PMID 20657643, Free PMC Article
    5. Diacylglycerol kinases terminate diacylglycerol signaling during the respiratory burst leading to heterogeneous phagosomal NADPH oxidase activation. Schlam D, et al. J Biol Chem, 2013 Aug 9. PMID 23814057, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Memantine, an NMDA receptor antagonist, improves working memory deficits in Diacylglycerol kinase (DGK) beta knockout mice. These findings may support the hypothesis that DGKbeta has a pivotal role in cognitive function.
      Title: Memantine, an NMDA receptor antagonist, improves working memory deficits in DGKβ knockout mice.
    2. These findings suggest that DGKbeta regulates the spine formation at distal dendrites in medium spiny neurons
      Title: Involvement of diacylglycerol kinase β in the spine formation at distal dendrites of striatal medium spiny neurons.
    3. This study demonistrated that Dgkb distribuate in mice cerebellum
      Title: Differential distribution of phospholipase C beta isoforms and diaglycerol kinase-beta in rodents cerebella corroborates the division of unipolar brush cells into two major subtypes.
    4. forced expression of diacylglycerol kinase beta abrogated DAG accumulation at the phagosome, leading to impaired respiratory burst.
      Title: Diacylglycerol kinases terminate diacylglycerol signaling during the respiratory burst leading to heterogeneous phagosomal NADPH oxidase activation.
    5. that DGKbeta KO mice showed attention-deficit and hyperactive phenotype, similar to ADHD.
      Title: Diacylglycerol kinase β knockout mice exhibit attention-deficit behavior and an abnormal response on methylphenidate-induced hyperactivity.
    6. Results demonstrate that membrane-localized DGKbeta regulates spine formation by regulation of lipids, contributing to the maintenance of neural networks in synaptic transmission of cognitive processes including memory.
      Title: Essential role of neuron-enriched diacylglycerol kinase (DGK), DGKbeta in neurite spine formation, contributing to cognitive function.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Transposon induced (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent diacylglycerol kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent diacylglycerol kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP-dependent diacylglycerol kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in diacylglycerol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in diacylglycerol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in diacylglycerol metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glycerolipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in modulation of chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidic acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidic acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidic acid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in phosphatidic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidic acid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of postsynapse organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynapse organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in Schaffer collateral - CA1 synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extrinsic component of postsynaptic density membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    diacylglycerol kinase beta
    Names
    DAG kinase beta
    diglyceride kinase beta
    NP_001348615.1
    NP_001348617.1
    NP_848796.2
    XP_006515130.1
    XP_006515131.1
    XP_006515133.1
    XP_006515134.1
    XP_017170508.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361686.1 → NP_001348615.1  diacylglycerol kinase beta isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC116471, AC141479, AC157494, AC157821, AC166996, CT009742, CT025577
      UniProtKB/Swiss-Prot
      Q6NS52, Q80TT5
      Conserved Domains (6) summary
      smart00045
      Location:580 → 760
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:438 → 559
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:244 → 293
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:152 → 221
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:309 → 358
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:6 → 148
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    2. NM_001361688.1 → NP_001348617.1  diacylglycerol kinase beta isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK139408, AK161933, AW493391, BC070461, BG088459
      Consensus CDS
      CCDS25889.1
      Related
      ENSMUSP00000152378.2, ENSMUST00000220990.2
      Conserved Domains (6) summary
      smart00045
      Location:573 → 753
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:431 → 552
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:237 → 286
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:145 → 214
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:302 → 353
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:7 → 141
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    3. NM_178681.5 → NP_848796.2  diacylglycerol kinase beta isoform 2

      See identical proteins and their annotated locations for NP_848796.2

      Status: VALIDATED

      Source sequence(s)
      AK139408, AW493391, BG088459, CJ128305
      Consensus CDS
      CCDS25889.1
      UniProtKB/Swiss-Prot
      Q6NS52
      Related
      ENSMUSP00000037900.8, ENSMUST00000040500.9
      Conserved Domains (6) summary
      smart00045
      Location:573 → 753
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:431 → 552
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:237 → 286
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:145 → 214
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:302 → 353
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:7 → 141
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      37930169..38684238
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515068.4 → XP_006515131.1  diacylglycerol kinase beta isoform X1

      See identical proteins and their annotated locations for XP_006515131.1

      Conserved Domains (6) summary
      smart00045
      Location:581 → 761
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:439 → 560
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:244 → 293
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:152 → 221
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:309 → 358
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:6 → 148
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    2. XM_017315019.3 → XP_017170508.1  diacylglycerol kinase beta isoform X2

      UniProtKB/Swiss-Prot
      Q6NS52, Q80TT5
      Conserved Domains (6) summary
      smart00045
      Location:580 → 760
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:438 → 559
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:244 → 293
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:152 → 221
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:309 → 358
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:6 → 148
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    3. XM_006515071.3 → XP_006515134.1  diacylglycerol kinase beta isoform X3

      See identical proteins and their annotated locations for XP_006515134.1

      Conserved Domains (6) summary
      smart00045
      Location:574 → 754
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:432 → 553
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:237 → 286
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:145 → 214
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:302 → 351
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:6 → 141
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    4. XM_006515070.4 → XP_006515133.1  diacylglycerol kinase beta isoform X3

      See identical proteins and their annotated locations for XP_006515133.1

      Conserved Domains (6) summary
      smart00045
      Location:574 → 754
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:432 → 553
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:237 → 286
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:145 → 214
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:302 → 351
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:6 → 141
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    5. XM_006515067.3 → XP_006515130.1  diacylglycerol kinase beta isoform X1

      See identical proteins and their annotated locations for XP_006515130.1

      Conserved Domains (6) summary
      smart00045
      Location:581 → 761
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:439 → 560
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:244 → 293
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:152 → 221
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:309 → 358
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:6 → 148
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NS52.2 GenPept UniProtKB/Swiss-Prot:Q6NS52

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