Ubtfl1 upstream binding transcription factor, RNA polymerase I-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ubtfl1provided by MGI
Official Full Name: upstream binding transcription factor, RNA polymerase I-like 1provided by MGI
Primary source: MGI:MGI:3588290
See related: Ensembl:ENSMUSG00000074502 AllianceGenome:MGI:3588290
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hmgpi; B020006M18Rik
Summary: Predicted to enable RNA polymerase I core promoter sequence-specific DNA binding activity and RNA polymerase I general transcription initiation factor activity. Acts upstream of or within blastocyst growth; embryo implantation; and regulation of gene expression. Located in cytoplasm and nucleus. Is expressed in early conceptus and oocyte. Orthologous to several human genes including UBTFL1 (upstream binding transcription factor like 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 9 A2; 9 7.04 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (18315714..18322798)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (18404418..18411502)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings indicate that CHD1 plays important roles in mouse early embryogenesis via activation of Hmgpi at zygotic gene activation.
Title: CHD1 acts via the Hmgpi pathway to regulate mouse early embryogenesis.
Reduction of Hmgpi transcript levels caused developmental loss of preimplantation embryos and implantation failures.
Title: Involvement of a novel preimplantation-specific gene encoding the high mobility group box protein Hmgpi in early embryonic development.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Markers

Ubtfl1 (e-PCR), detects polymorphism
- UniSTS:528236

Ubtfl1 (e-PCR), detects polymorphism
- UniSTS:528237

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase I core promoter sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase I general transcription initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blastocyst growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryo implantation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase I	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription by RNA polymerase I	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: upstream-binding factor 1-like protein 1

Names: HMG-box preimplantation embryo-specific protein; HMG-box protein, preimplantation-embryo-specific

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033793.3 → NP_001028965.1 upstream-binding factor 1-like protein 1

See identical proteins and their annotated locations for NP_001028965.1

Status: VALIDATED

Source sequence(s)

AK139937, AK163257, BB289342

Consensus CDS

CCDS40540.1

UniProtKB/Swiss-Prot

Q3TQX0, Q3USZ2

Related

ENSMUSP00000129611.2, ENSMUST00000164441.2

Conserved Domains (1) summary

cd01390
Location:101 → 166

HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...
NM_001360216.1 → NP_001347145.1 upstream-binding factor 1-like protein 1

Status: VALIDATED

Source sequence(s)

AC162941

Consensus CDS

CCDS40540.1

UniProtKB/Swiss-Prot

Q3TQX0, Q3USZ2

Related

ENSMUSP00000126540.2, ENSMUST00000169398.3

Conserved Domains (1) summary

cd01390
Location:101 → 166

HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...