Gal3st2 galactose-3-O-sulfotransferase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gal3st2provided by MGI
Official Full Name: galactose-3-O-sulfotransferase 2provided by MGI
Primary source: MGI:MGI:2685834
See related: Ensembl:ENSMUSG00000094651 AllianceGenome:MGI:2685834
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GP3ST; Gm988
Summary: Enables galactose 3-O-sulfotransferase activity. Acts upstream of or within glycoprotein biosynthetic process and sulfation. Located in membrane. Orthologous to human GAL3ST2 (galactose-3-O-sulfotransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in duodenum adult (RPKM 54.5), small intestine adult (RPKM 44.1) and 2 other tissues See more
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Genomic context

Location:: 1 D; 1 47.38 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (93789066..93804220)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (93861344..93876494)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GAL3ST2 interferes with normal differentiation of 3T3-L1 preadipocytes, leading to decreased triglyceride accumulation decreased adipogenic marker expression.
Title: GAL3ST2 from mammary gland epithelial cells affects differentiation of 3T3-L1 preadipocytes.
The substrate specificity and cofactor requirements of human, porcine, and murine GAL3ST are reported
Title: Porcine, mouse and human galactose 3-O-sulphotransferase-2 enzymes have different substrate specificities; the porcine enzyme requires basic compounds for its catalytic activity.

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General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables galactose 3-O-sulfotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables galactose 3-O-sulfotransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables galactosylceramide sulfotransferase activity	IEA Inferred from Electronic Annotation more info
enables sulfotransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in glycolipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in glycoprotein biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glycoprotein biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within sulfation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi cisterna membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: galactose-3-O-sulfotransferase 2

Names: beta-galactose-3-O-sulfotransferase 2; gal-beta-1, 3-GalNAc 3'-sulfotransferase 2; gal3ST-2

NP_955398.3

EC 2.8.2.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199366.5 → NP_955398.3 galactose-3-O-sulfotransferase 2

Status: VALIDATED

Source sequence(s)

AC167139

Consensus CDS

CCDS15197.1

UniProtKB/TrEMBL

A2RTS9, Q3UN22

Related

ENSMUSP00000092250.3, ENSMUST00000094663.4

Conserved Domains (1) summary

cl22970
Location:1 → 382

Sulfotransfer_2; Sulfotransferase family