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    Slc4a7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 [ Mus musculus (house mouse) ]

    Gene ID: 218756, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc4a7provided by MGI
    Official Full Name
    solute carrier family 4, sodium bicarbonate cotransporter, member 7provided by MGI
    Primary source
    MGI:MGI:2443878
    See related
    Ensembl:ENSMUSG00000021733 AllianceGenome:MGI:2443878
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NBC3; NBCn1; NBCn1-G; E430014N10Rik; Tg(Thy1-SNCA)12Mjff
    Summary
    Enables sodium:bicarbonate symporter activity. Involved in locomotory exploration behavior; regulation of intracellular pH; and sensory perception of sound. Acts upstream of or within eye development; nervous system development; and visual perception. Located in apical plasma membrane; basolateral plasma membrane; and cytoplasm. Is expressed in brain; metanephros; pancreas; and spiral ligament. Used to study Usher syndrome type 2C. Orthologous to human SLC4A7 (solute carrier family 4 member 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 6.9), CNS E14 (RPKM 6.6) and 27 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Slc4a7 in Genome Data Viewer
    Location:
    14 A1; 14 7.08 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (7669819..7766808, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (14703011..14799944)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_36001 Neighboring gene predicted gene, 18142 Neighboring gene predicted gene, 46441 Neighboring gene NIMA (never in mitosis gene a)- related kinase 10 Neighboring gene STARR-seq mESC enhancer starr_36000 Neighboring gene STARR-seq mESC enhancer starr_35999 Neighboring gene STARR-seq mESC enhancer starr_35997 Neighboring gene STARR-positive B cell enhancer ABC_E749 Neighboring gene STARR-seq mESC enhancer starr_35996 Neighboring gene predicted gene, 52165 Neighboring gene NSA2 ribosome biogenesis homolog pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • C330023F04, E430014N10Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables monoatomic anion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sodium:bicarbonate symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sodium:bicarbonate symporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables sodium:bicarbonate symporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables solute:inorganic anion antiporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in auditory receptor cell development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within auditory receptor cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in bicarbonate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in bicarbonate transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within camera-type eye photoreceptor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cochlear nucleus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in inorganic anion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in locomotory exploration behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in monoatomic anion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phagosome acidification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in purine nucleotide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in pyrimidine nucleotide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of intracellular pH IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of intracellular pH IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within retina vasculature morphogenesis in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within retinal cell programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within visual perception IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in stereocilium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in stereocilium ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    sodium bicarbonate cotransporter 3
    Names
    Na-bicarbonate cotransporter
    sodium bicarbonate cotransporter NBCn1-A
    sodium bicarbonate cotransporter NBCn1-B
    sodium bicarbonate cotransporter NBCn1-D
    sodium bicarbonate cotransporter NBCn1-H
    sodium bicarbonate cotransporter NBCn1-c

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033270.2NP_001028442.2  sodium bicarbonate cotransporter 3 isoform 11

      See identical proteins and their annotated locations for NP_001028442.2

      Status: VALIDATED

      Source sequence(s)
      AC129580, CT025538
      Consensus CDS
      CCDS36810.1
      UniProtKB/Swiss-Prot
      Q3U5H7, Q8BTY2
      UniProtKB/TrEMBL
      F8VQC9
      Related
      ENSMUSP00000058313.7, ENSMUST00000057015.8
      Conserved Domains (4) summary
      TIGR00834
      Location:1181016
      ae; anion exchange protein
      pfam00955
      Location:456969
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:146413
      Band_3_cyto; Band 3 cytoplasmic domain
      pfam10487
      Location:599667
      Nup188; Nucleoporin subcomplex protein binding to Pom34
    2. NM_001360504.1NP_001347433.1  sodium bicarbonate cotransporter 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC129580, AK153567, BP761907, CD541823, CO430686, JX254910
      Consensus CDS
      CCDS88573.1
      UniProtKB/TrEMBL
      A0A286YCX2, A0A286YD14, J9RV59
      Related
      ENSMUSP00000153045.3, ENSMUST00000223761.3
      Conserved Domains (1) summary
      cl26877
      Location:1181139
      Band_3_cyto; Band 3 cytoplasmic domain
    3. NM_001360505.1NP_001347434.1  sodium bicarbonate cotransporter 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC129580, AK153567, BP761907, CD541823, CO430686, JX254909
      UniProtKB/TrEMBL
      A0A286YCX2, J9RZB2
      Related
      ENSMUSP00000153180.3, ENSMUST00000223607.3
      Conserved Domains (1) summary
      cl26877
      Location:1181126
      Band_3_cyto; Band 3 cytoplasmic domain
    4. NM_001360506.1NP_001347435.1  sodium bicarbonate cotransporter 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC129580, AK153567, BP761907, CD541823, CO430686, JX254908
      UniProtKB/TrEMBL
      A0A286YD46, J9S4N6
      Related
      ENSMUSP00000153084.3, ENSMUST00000223981.3
      Conserved Domains (1) summary
      cl26877
      Location:1181139
      Band_3_cyto; Band 3 cytoplasmic domain
    5. NM_001360508.1NP_001347437.1  sodium bicarbonate cotransporter 3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC129580, BP761907, CD541823, CO430686, CT025538, JX254912
      UniProtKB/TrEMBL
      A0A286YDK8, J9S7F7
      Related
      ENSMUSP00000153470.3, ENSMUST00000224333.3
      Conserved Domains (1) summary
      cl26877
      Location:1131134
      Band_3_cyto; Band 3 cytoplasmic domain
    6. NM_001360509.1NP_001347438.1  sodium bicarbonate cotransporter 3 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC129580, AK153567, BP761907, CD541823, CO430686, JX254911
      Consensus CDS
      CCDS88570.1
      UniProtKB/TrEMBL
      A0A286YD46, A0A286YDA9, J9RDH0
      Related
      ENSMUSP00000153166.3, ENSMUST00000225175.3
      Conserved Domains (1) summary
      cl26877
      Location:1181126
      Band_3_cyto; Band 3 cytoplasmic domain
    7. NM_001360510.1NP_001347439.1  sodium bicarbonate cotransporter 3 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC129580, BP761907, CD541823, CO430686, CT025538, HM624051
      Consensus CDS
      CCDS88576.1
      UniProtKB/TrEMBL
      A0A286YCU2, A0A286YDK8, E3UVT9
      Related
      ENSMUSP00000152950.3, ENSMUST00000224672.3
      Conserved Domains (1) summary
      cl26877
      Location:1131121
      Band_3_cyto; Band 3 cytoplasmic domain
    8. NM_001360511.1NP_001347440.1  sodium bicarbonate cotransporter 3 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC129580, AK153567, BP761907, CD541823, CO430686, JQ349031
      Consensus CDS
      CCDS88574.1
      UniProtKB/Swiss-Prot
      Q3U5H7, Q8BTY2
      UniProtKB/TrEMBL
      A0A286YCH3, I1VGT4
      Related
      ENSMUSP00000152984.3, ENSMUST00000225238.3
      Conserved Domains (1) summary
      cl26877
      Location:1181036
      Band_3_cyto; Band 3 cytoplasmic domain
    9. NM_001360512.1NP_001347441.1  sodium bicarbonate cotransporter 3 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC129580, BP761907, CD541823, CO430686, CT025538, JQ347261
      Consensus CDS
      CCDS88579.1
      UniProtKB/TrEMBL
      A0A286YDB4, H6WZF5, U3RKD2
      Related
      ENSMUSP00000153345.3, ENSMUST00000224952.3
      Conserved Domains (1) summary
      cl26877
      Location:1131031
      Band_3_cyto; Band 3 cytoplasmic domain
    10. NM_001360513.1NP_001347442.1  sodium bicarbonate cotransporter 3 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC129580, AK153567, BP761907, CD541823, CO430686, JQ349032
      Consensus CDS
      CCDS88571.1
      UniProtKB/Swiss-Prot
      Q3U5H7, Q8BTY2
      UniProtKB/TrEMBL
      A0A286YED8, I1VGT5
      Related
      ENSMUSP00000153690.3, ENSMUST00000225979.3
      Conserved Domains (1) summary
      cl26877
      Location:1181023
      Band_3_cyto; Band 3 cytoplasmic domain
    11. NM_001360514.1NP_001347443.1  sodium bicarbonate cotransporter 3 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC129580, BP761907, CD541823, CO430686, CT025538, JQ349033
      Consensus CDS
      CCDS88577.1
      UniProtKB/Swiss-Prot
      Q3U5H7, Q8BTY2
      UniProtKB/TrEMBL
      A0A286YDZ8, I1VGT6
      Related
      ENSMUSP00000153648.3, ENSMUST00000223695.3
      Conserved Domains (1) summary
      cl26877
      Location:1131018
      Band_3_cyto; Band 3 cytoplasmic domain
    12. NM_001360515.1NP_001347444.1  sodium bicarbonate cotransporter 3 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC129580, BP761907, CD541823, CO430686, CT025538, HM624050
      Consensus CDS
      CCDS88580.1
      UniProtKB/TrEMBL
      A0A286YCE1, E3UVT8, U3RKD2
      Related
      ENSMUSP00000152933.3, ENSMUST00000223740.3
      Conserved Domains (1) summary
      cl26877
      Location:1131011
      Band_3_cyto; Band 3 cytoplasmic domain
    13. NM_001360516.1NP_001347445.1  sodium bicarbonate cotransporter 3 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC129580, AK153567, BP761907, CD541823, CO430686, GU386352
      Consensus CDS
      CCDS88572.1
      UniProtKB/Swiss-Prot
      Q3U5H7, Q8BTY2
      UniProtKB/TrEMBL
      A0A286YDX4, D3Y272
      Related
      ENSMUSP00000153597.3, ENSMUST00000225630.3
      Conserved Domains (1) summary
      cl26877
      Location:1181003
      Band_3_cyto; Band 3 cytoplasmic domain
    14. NM_001360517.1NP_001347446.1  sodium bicarbonate cotransporter 3 isoform 15

      Status: VALIDATED

      Source sequence(s)
      AC129580, AK153567, BP761907, CD541823, CO430686, GU386353
      Consensus CDS
      CCDS88575.1
      UniProtKB/TrEMBL
      A0A286YD46, A0A286YD88, D3Y273
      Related
      ENSMUSP00000153323.3, ENSMUST00000226079.3
      Conserved Domains (1) summary
      cl26877
      Location:1181016
      Band_3_cyto; Band 3 cytoplasmic domain
    15. NM_001360520.1NP_001347449.1  sodium bicarbonate cotransporter 3 isoform 14

      Status: VALIDATED

      Source sequence(s)
      AC129580, BP761907, CD541823, CO430686, CT025538, JQ344322
      Consensus CDS
      CCDS88578.1
      UniProtKB/Swiss-Prot
      Q3U5H7, Q8BTY2
      UniProtKB/TrEMBL
      A0A286YCQ1, H6WZ45
      Related
      ENSMUSP00000153093.3, ENSMUST00000224049.3
      Conserved Domains (1) summary
      cl26877
      Location:113998
      Band_3_cyto; Band 3 cytoplasmic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      7669819..7766808 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315953.2XP_017171442.1  sodium bicarbonate cotransporter 3 isoform X3

      UniProtKB/TrEMBL
      A0A286YD46
      Conserved Domains (1) summary
      cl26877
      Location:1181159
      Band_3_cyto; Band 3 cytoplasmic domain
    2. XM_006517998.2XP_006518061.1  sodium bicarbonate cotransporter 3 isoform X1

      UniProtKB/TrEMBL
      A0A286YCX2
      Conserved Domains (1) summary
      cl26877
      Location:1181159
      Band_3_cyto; Band 3 cytoplasmic domain
    3. XM_017315955.3XP_017171444.1  sodium bicarbonate cotransporter 3 isoform X4

      UniProtKB/TrEMBL
      A0A286YCX8, U3RF68
      Related
      ENSMUSP00000153185.3, ENSMUST00000224752.3
      Conserved Domains (1) summary
      cl26877
      Location:1231131
      Band_3_cyto; Band 3 cytoplasmic domain
    4. XM_006517999.3XP_006518062.1  sodium bicarbonate cotransporter 3 isoform X2

      UniProtKB/TrEMBL
      A0A286YCX2
      Conserved Domains (1) summary
      cl26877
      Location:1181146
      Band_3_cyto; Band 3 cytoplasmic domain

    RNA

    1. XR_001781108.2 RNA Sequence