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    Mex3d mex3 RNA binding family member D [ Mus musculus (house mouse) ]

    Gene ID: 237400, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mex3dprovided by MGI
    Official Full Name
    mex3 RNA binding family member Dprovided by MGI
    Primary source
    MGI:MGI:2681847
    See related
    Ensembl:ENSMUSG00000048696 AllianceGenome:MGI:2681847
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rkhd1
    Summary
    Predicted to enable mRNA 3'-UTR AU-rich region binding activity. Predicted to act upstream of or within RNA destabilization and mRNA catabolic process. Predicted to be located in nucleus and perinuclear region of cytoplasm. Is expressed in cerebral cortex intermediate zone; cerebral cortex subventricular zone; and cortical plate. Orthologous to human MEX3D (mex-3 RNA binding family member D). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 193.1), ovary adult (RPKM 36.0) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mex3d in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80216189..80223485, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80380355..80387651, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene ADAMTS-like 5 Neighboring gene polo like kinase 5 Neighboring gene predicted gene, 30823 Neighboring gene RIKEN cDNA 3300002P09 gene Neighboring gene methyl-CpG binding domain protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of TINO: a new evolutionarily conserved BCL-2 AU-rich element RNA-binding protein. Donnini M, et al. J Biol Chem, 2004 May 7. PMID 14769789
    2. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article
    3. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC69704

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mRNA 3'-UTR AU-rich region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA 3'-UTR AU-rich region binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA destabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA destabilization NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein MEX3D
    Names
    RING finger and KH domain-containing protein 1
    mex3 homolog D
    ring finger (C3HC4 type) and KH domain containing 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198615.2 → NP_941017.2  RNA-binding protein MEX3D

      Status: VALIDATED

      Source sequence(s)
      AC152062, AK149801, BC059858, BX514891
      Consensus CDS
      CCDS48629.1
      UniProtKB/Swiss-Prot
      Q3UE17
      UniProtKB/TrEMBL
      D3YTR3, E9PUA0
      Related
      ENSMUSP00000100987.3, ENSMUST00000105350.3
      Conserved Domains (3) summary
      smart00322
      Location:328 → 393
      KH; K homology RNA-binding domain
      cd00105
      Location:235 → 296
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam13920
      Location:665 → 712
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      80216189..80223485 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513619.4 → XP_006513682.1  RNA-binding protein MEX3D isoform X1

      UniProtKB/Swiss-Prot
      Q3UE17
      Conserved Domains (5) summary
      smart00322
      Location:328 → 393
      KH; K homology RNA-binding domain
      PHA03247
      Location:27 → 215
      PHA03247; large tegument protein UL36; Provisional
      cd00105
      Location:235 → 296
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd00162
      Location:667 → 706
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cl17238
      Location:665 → 709
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UE17.2 GenPept UniProtKB/Swiss-Prot:Q3UE17

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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