Trim61 tripartite motif-containing 61 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trim61provided by MGI
Official Full Name: tripartite motif-containing 61provided by MGI
Primary source: MGI:MGI:2387432
See related: Ensembl:ENSMUSG00000109718 AllianceGenome:MGI:2387432
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rnf35; 2czf61; E330039K03Rik
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response. Predicted to be active in cytosol. Is expressed in central nervous system; early conceptus; secondary oocyte; and testis. Orthologous to human TRIM61 (tripartite motif containing 61). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in ovary adult (RPKM 1.5) and kidney adult (RPKM 0.2) See more
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Genomic context

Location:: 8 B3.1; 8 32.52 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (65465628..65471340, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (65012976..65018688, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that the Rnf35 promoter is negatively modulated by the repressor element, DER, and that the 3'-half of DER (DER2) was targeted by the repressor CCAAT-displacement protein (CDP)/Cux.
Title: Negative transcriptional modulation and silencing of the bi-exonic Rnf35 gene in the preimplantation embryo. Binding of the CCAAT-displacement protein/Cux to the untranslated exon 1 sequence.
Regulation of transcription and pre-mRNA processing of Rnf35 in eggs and in pre-implantation embryos.
Title: Different modes of regulation of transcription and pre-mRNA processing of the structurally juxtaposed homologs, Rnf33 and Rnf35, in eggs and in pre-implantation embryos.
Rnf33 and Rnf35 mRNAs are apparently transcribed from the same putative promoter and may be products of alternative splicing.
Title: Use of a common promoter by two juxtaposed and intronless mouse early embryonic genes, Rnf33 and Rnf35: implications in zygotic gene expression.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

General gene information

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Markers

RH136249 (e-PCR)
- UniSTS:210243

NoName (e-PCR)
- UniSTS:235902

RH127152 (e-PCR)
- UniSTS:208286

Trim61 (e-PCR), detects polymorphism
- UniSTS:256956

Rnf35 (e-PCR), detects polymorphism
- UniSTS:256957

PMC137171P1 (e-PCR)
- UniSTS:270819

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: putative tripartite motif-containing protein 61

Names: ring finger protein 35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001177551.1 → NP_001171022.1 putative tripartite motif-containing protein 61

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK054544, BB709545, CF175045

Consensus CDS

CCDS22332.1

UniProtKB/TrEMBL

Q6P242, Q8JZK6

Related

ENSMUSP00000077513.4, ENSMUST00000078409.5

Conserved Domains (2) summary

cd15828
Location:272 → 456

SPRY_PRY_TRIM60; PRY/SPRY domain of tripartite motif-binding protein 60 (TRIM60) also known as RING finger protein 33 (RNF33)

cl17238
Location:16 → 56

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
NM_153110.4 → NP_694750.3 putative tripartite motif-containing protein 61

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK054544, BB709545, BC064738, CF175045

Consensus CDS

CCDS22332.1

UniProtKB/TrEMBL

Q6P242, Q8JZK6

Conserved Domains (2) summary

cd15828
Location:272 → 456

SPRY_PRY_TRIM60; PRY/SPRY domain of tripartite motif-binding protein 60 (TRIM60) also known as RING finger protein 33 (RNF33)

cl17238
Location:16 → 56

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...