Jam2 junction adhesion molecule 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Jam2provided by MGI
Official Full Name: junction adhesion molecule 2provided by MGI
Primary source: MGI:MGI:1933820
See related: Ensembl:ENSMUSG00000053062 AllianceGenome:MGI:1933820
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: JAM-2; JAM-B; Jcam2; VE-JAM; 1110002N23Rik; 2410030G21Rik; 2410167M24Rik
Summary: Predicted to enable integrin binding activity. Involved in several processes, including hematopoietic stem cell migration to bone marrow; leukocyte tethering or rolling; and negative regulation of myelination. Acts upstream of or within negative regulation of cell adhesion. Located in cell surface; somatodendritic compartment; and tight junction. Is expressed in several structures, including alimentary system; brain; cardiovascular system; eye; and genitourinary system. Human ortholog(s) of this gene implicated in basal ganglia calcification. Orthologous to human JAM2 (junctional adhesion molecule 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in heart adult (RPKM 20.4), frontal lobe adult (RPKM 12.0) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 C3.3; 16 46.92 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (84571011..84623268)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (84774123..84826380)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Frequency of Jam2(high) hematopoietic stem cell (HCSs) changes upon T cell depletion in vivo, potentially suggesting that Jam2 expression may reflect scarcity of T cells and requirement of T cell replenishment. These findings highlight Jam2 as a potential marker for a subfraction of HSCs with an extensive lymphopoietic capacity, mainly in T lymphopoiesis.
Title: Junctional Adhesion Molecule 2 Represents a Subset of Hematopoietic Stem Cells with Enhanced Potential for T Lymphopoiesis.
results provided evidence for JAM-B as a novel antiangiogenic factor through regulation of VEGF signaling in vitro, but this effect did not extend to in vivo studies.
Title: Junctional adhesion molecule B interferes with angiogenic VEGF/VEGFR2 signaling.
this study shows that JAM-B promotes autoimmune-mediated liver fibrosis in mice
Title: Junctional adhesion molecules JAM-B and JAM-C promote autoimmune-mediated liver fibrosis in mice.
JAM-B/JAM-C mediated interaction between endothelial cells and stellate cells stabilizes vessel walls and may control the sinusoidal diameter.
Title: Murine junctional adhesion molecules JAM-B and JAM-C mediate endothelial and stellate cell interactions during hepatic fibrosis.
JAM-B is an as yet underappreciated trophoblast lineage-specific protein, which is modulated via the progesterone receptor and shows unique strain-specific kinetics.
Title: Differential mouse-strain specific expression of Junctional Adhesion Molecule (JAM)-B in placental structures.
identify neuronal junction adhesion molecule 2 (JAM2) as an inhibitory myelin-guidance molecule.
Title: Somatodendritic Expression of JAM2 Inhibits Oligodendrocyte Myelination.
TGF-beta3 significantly downregulates JAM-B expression via post-transcriptional and post-translational modulation and results in the disruption of BTB and apical ES.
Title: Transforming growth factor-β3 regulates cell junction restructuring via MAPK-mediated mRNA destabilization and Smad-dependent protein degradation of junctional adhesion molecule B (JAM-B).
Function of Jam-B/Jam-C interaction in homing and mobilization of human and mouse hematopoietic stem and progenitor cells.
Title: Function of Jam-B/Jam-C interaction in homing and mobilization of human and mouse hematopoietic stem and progenitor cells.
Data show that junctional adhesion molecule-B (JAM-B) expressed by endothelial cells contributes to murine B16 melanoma cells metastasis through its interaction with junctional adhesion molecule-C (JAM-C) on tumor cells.
Title: The Junctional Adhesion Molecule-B regulates JAM-C-dependent melanoma cell metastasis.
Jam2 has a role in the interaction between hatched blastocyst and receptive uterus.
Title: Junctional adhesion molecule 2 mediates the interaction between hatched blastocyst and luminal epithelium: induction by progesterone and LIF.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Jam2 (e-PCR), detects polymorphism
- UniSTS:259097

Jam2 (e-PCR), detects polymorphism
- UniSTS:259625

RH130790 (e-PCR)
- UniSTS:214074

AU016127 (e-PCR)
- UniSTS:160587

Jam2 (e-PCR), detects polymorphism
- UniSTS:516176

Jam2 (e-PCR), detects polymorphism
- UniSTS:507003

NoName (e-PCR)
- UniSTS:237535

NoName (e-PCR)
- UniSTS:237536

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cellular extravasation	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular extravasation	ISO Inferred from Sequence Orthology more info
involved_in hematopoietic stem cell migration to bone marrow	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hematopoietic stem cell migration to bone marrow	ISO Inferred from Sequence Orthology more info
involved_in leukocyte cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in leukocyte tethering or rolling	IDA Inferred from Direct Assay more info	PubMed
involved_in leukocyte tethering or rolling	ISO Inferred from Sequence Orthology more info
involved_in lymphocyte aggregation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell adhesion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of myelination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of lymphocyte migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of lymphocyte migration	ISO Inferred from Sequence Orthology more info
involved_in spermatid development	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
NOT located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell-cell contact zone	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of protein complex involved in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
part_of protein complex involved in cell adhesion	ISO Inferred from Sequence Orthology more info
part_of protein complex involved in cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
located_in somatodendritic compartment	IDA Inferred from Direct Assay more info	PubMed
is_active_in tight junction	IBA Inferred from Biological aspect of Ancestor more info
located_in tight junction	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: junctional adhesion molecule B

Names: junction adhesion molecule B; junction cell adhesion molecule 2; junctional adhesion molecule 2; vascular endothelial junction-associated molecule

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023844.5 → NP_076333.3 junctional adhesion molecule B precursor

See identical proteins and their annotated locations for NP_076333.3

Status: VALIDATED

Source sequence(s)

AC164162, BC028778

Consensus CDS

CCDS37381.1

UniProtKB/Swiss-Prot

A6X955, Q8C5K9, Q8CE95, Q9JI59

UniProtKB/TrEMBL

A0A338P721

Related

ENSMUSP00000109833.2, ENSMUST00000114195.8

Conserved Domains (3) summary

cd00096
Location:47 → 113

Ig; Immunoglobulin domain

smart00408
Location:149 → 221

IGc2; Immunoglobulin C-2 Type

smart00410
Location:143 → 221

IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

84571011..84623268

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006523075.5 → XP_006523138.1 junctional adhesion molecule B isoform X1

UniProtKB/TrEMBL

A0A338P721

Related

ENSMUSP00000156235.2, ENSMUST00000231910.2

Conserved Domains (2) summary

smart00408
Location:190 → 262

IGc2; Immunoglobulin C-2 Type

cl11960
Location:76 → 151

Ig; Immunoglobulin domain