Ing5 inhibitor of growth family, member 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ing5provided by MGI
Official Full Name: inhibitor of growth family, member 5provided by MGI
Primary source: MGI:MGI:1922816
See related: Ensembl:ENSMUSG00000026283 AllianceGenome:MGI:1922816
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1700001C14Rik; 1700027H23Rik; 1810018M11Rik
Summary: Enables chromatin binding activity. Acts upstream of or within negative regulation of fibroblast proliferation and positive regulation of apoptotic signaling pathway. Predicted to be located in nucleoplasm. Predicted to be part of MOZ/MORF histone acetyltransferase complex. Predicted to be active in nucleus. Is expressed in 1st branchial arch maxillary component; central nervous system; early conceptus; eye; and genitourinary system. Orthologous to human ING5 (inhibitor of growth family member 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 7.0), CNS E11.5 (RPKM 6.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 D; 1 47.34 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (93731648..93749823)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (93803926..93822101)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ING4 and ING5 are essential for histone H3 lysine 14 acetylation and epicardial cell lineage development.
Title: ING4 and ING5 are essential for histone H3 lysine 14 acetylation and epicardial cell lineage development.
The chromatin reader protein ING5 is required for normal hematopoietic cell numbers in the fetal liver.
Title: The chromatin reader protein ING5 is required for normal hematopoietic cell numbers in the fetal liver.
Expression analysis of microRNAs and mRNAs in myofibroblast differentiation of lung resident mesenchymal stem cells.
Title: Expression analysis of microRNAs and mRNAs in myofibroblast differentiation of lung resident mesenchymal stem cells.
ING5 inhibits cell proliferation and invasion in esophageal squamous cell carcinoma through regulation of the Akt/NF-kappaB/MMP-9 signaling pathway.
Title: ING5 inhibits cell proliferation and invasion in esophageal squamous cell carcinoma through regulation of the Akt/NF-κB/MMP-9 signaling pathway.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IGI Inferred from Genetic Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methylated histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables methylated histone binding	IEA Inferred from Electronic Annotation more info
enables methylated histone binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA replication-dependent chromatin disassembly	ISO Inferred from Sequence Orthology more info
involved_in DNA replication-dependent chromatin disassembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of apoptotic signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of fibroblast proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of fibroblast proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of growth	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein acetylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA replication	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of developmental process	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of hemopoiesis	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of MOZ/MORF histone acetyltransferase complex	ISO Inferred from Sequence Orthology more info
part_of MOZ/MORF histone acetyltransferase complex	ISS Inferred from Sequence or Structural Similarity more info
part_of histone acetyltransferase complex	ISO Inferred from Sequence Orthology more info
part_of histone acetyltransferase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: inhibitor of growth protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025454.2 → NP_079730.1 inhibitor of growth protein 5

See identical proteins and their annotated locations for NP_079730.1

Status: VALIDATED

Source sequence(s)

AK007536, AK028397, CAAA01224355

Consensus CDS

CCDS35673.1

UniProtKB/Swiss-Prot

Q3UL57, Q6P292, Q9CV64, Q9D8Y8, Q9D9V8

Related

ENSMUSP00000027505.7, ENSMUST00000027505.13

Conserved Domains (2) summary

cd15685
Location:187 → 235

PHD_ING5; PHD finger found in inhibitor of growth protein 5 (ING5)

pfam12998
Location:6 → 105

ING; Inhibitor of growth proteins N-terminal histone-binding

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

93731648..93749823

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006529792.4 → XP_006529855.1 inhibitor of growth protein 5 isoform X1

Conserved Domains (2) summary

cd15685
Location:186 → 234

PHD_ING5; PHD finger found in inhibitor of growth protein 5 (ING5)

cd16863
Location:12 → 104

ING_ING5; Inhibitor of growth (ING) domain of inhibitor of growth protein 5 (ING5)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_029340.1: Suppressed sequence

Description

NM_029340.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.