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    Taf9b TATA-box binding protein associated factor 9B [ Mus musculus (house mouse) ]

    Gene ID: 407786, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Taf9bprovided by MGI
    Official Full Name
    TATA-box binding protein associated factor 9Bprovided by MGI
    Primary source
    MGI:MGI:3039562
    See related
    Ensembl:ENSMUSG00000047242 AllianceGenome:MGI:3039562
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Taf9l
    Summary
    Predicted to enable protein heterodimerization activity. Predicted to contribute to RNA polymerase II general transcription initiation factor activity. Predicted to be involved in several processes, including negative regulation of transcription by RNA polymerase II; positive regulation of cell growth; and protein stabilization. Predicted to be located in nucleus. Predicted to be part of transcription factor TFIID complex and transcription factor TFTC complex. Is expressed in tail. Orthologous to human TAF9B (TATA-box binding protein associated factor 9b). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 7.0), cortex adult (RPKM 6.5) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Taf9b in Genome Data Viewer
    Location:
    X D; X 47.36 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (105250480..105264764, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (106206874..106221158, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene TM2 domain containing 2 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1985 Neighboring gene phosphoglycerate kinase 1 Neighboring gene fibronectin type III domain containing 3C2 Neighboring gene fibronectin type III domain containing 3C2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Core promoter factor TAF9B regulates neuronal gene expression. Herrera FJ, et al. Elife, 2014 Jul 8. PMID 25006164, Free PMC Article
    2. Targeted deletion of CASK-interacting nucleosome assembly protein causes higher locomotor and exploratory activities. Chung WC, et al. Neurosignals, 2011. PMID 21576927
    3. Single-cell RNA-Seq reveals a highly coordinated transcriptional program in mouse germ cells during primordial follicle formation. He Y, et al. Aging Cell, 2021 Jul. PMID 34174788, Free PMC Article
    4. The TAF10-containing TFIID and SAGA transcriptional complexes are dispensable for early somitogenesis in the mouse embryo. Bardot P, et al. Development, 2017 Oct 15. PMID 28893950, Free PMC Article
    5. Phenotypic annotation of the mouse X chromosome. Cox BJ, et al. Genome Res, 2010 Aug. PMID 20548051, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TAF9B also regulates neuronal gene transcription in vivo.
      Title: Core promoter factor TAF9B regulates neuronal gene expression.
    2. These observations suggest that although CINAP deletion in mice does not influence learning and memory behaviors, CINAP is required for restriction of locomotor and exploratory activities.
      Title: Targeted deletion of CASK-interacting nucleosome assembly protein causes higher locomotor and exploratory activities.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to RNA polymerase II general transcription initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIID complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFTC complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transcription initiation factor TFIID subunit 9B
    Names
    TAF9-like RNA polymerase II, TATA box binding protein (TBP)-associated factor
    TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor
    transcription-associated factor TAFII31L
    NP_001001176.2
    NP_001161460.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001176.2 → NP_001001176.2  transcription initiation factor TFIID subunit 9B isoform 2

      See identical proteins and their annotated locations for NP_001001176.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      BC051635, BC066223, CA559941
      Consensus CDS
      CCDS30340.1
      UniProtKB/Swiss-Prot
      A2AP80, Q3UXZ3, Q3V2M4, Q6NZA9, Q80WW6
      Related
      ENSMUSP00000059751.9, ENSMUST00000055497.15
      Conserved Domains (1) summary
      cd07979
      Location:13 → 129
      TAF9; TATA Binding Protein (TBP) Associated Factor 9 (TAF9) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

    2. NM_001167988.1 → NP_001161460.1  transcription initiation factor TFIID subunit 9B isoform 1

      See identical proteins and their annotated locations for NP_001161460.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK131710, BC066223
      Consensus CDS
      CCDS53170.1
      UniProtKB/TrEMBL
      A2AP82
      Related
      ENSMUSP00000109123.3, ENSMUST00000113495.9
      Conserved Domains (1) summary
      cd07979
      Location:57 → 173
      TAF9; TATA Binding Protein (TBP) Associated Factor 9 (TAF9) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      105250480..105264764 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NZA9.2 GenPept UniProtKB/Swiss-Prot:Q6NZA9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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