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    Lrmda leucine rich melanocyte differentiation associated [ Mus musculus (house mouse) ]

    Gene ID: 76633, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Lrmdaprovided by MGI
    Official Full Name
    leucine rich melanocyte differentiation associatedprovided by MGI
    Primary source
    MGI:MGI:1923883
    See related
    Ensembl:ENSMUSG00000063458 AllianceGenome:MGI:1923883
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700112E06Rik; 2700009F18Rik
    Summary
    Predicted to be involved in melanocyte differentiation. Is expressed in embryo. Human ortholog(s) of this gene implicated in oculocutaneous albinism type VII. Orthologous to human LRMDA (leucine rich melanocyte differentiation associated). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Lrmda in Genome Data Viewer
    Location:
    14 A3; 14 12.03 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (22069567..23106161)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (22019504..23056093)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A330001L22 gene Neighboring gene VISTA enhancer mm414 Neighboring gene predicted gene, 41106 Neighboring gene predicted gene, 41107 Neighboring gene STARR-seq mESC enhancer starr_36161 Neighboring gene RIKEN cDNA 4930405A10 gene Neighboring gene predicted gene, 53836 Neighboring gene STARR-seq mESC enhancer starr_36162 Neighboring gene 60S ribosomal protein L31 pseudogene Neighboring gene STARR-seq mESC enhancer starr_36163 Neighboring gene STARR-seq mESC enhancer starr_36164 Neighboring gene STARR-seq mESC enhancer starr_36166 Neighboring gene STARR-seq mESC enhancer starr_36167 Neighboring gene predicted gene, 30926 Neighboring gene predicted gene 7473 Neighboring gene ribosomal protein L15 pseudogene Neighboring gene predicted gene, 30783 Neighboring gene predicted gene, 53835 Neighboring gene STARR-seq mESC enhancer starr_36168 Neighboring gene STARR-seq mESC enhancer starr_36169 Neighboring gene predicted gene 10248 Neighboring gene STARR-seq mESC enhancer starr_36171 Neighboring gene STARR-seq mESC enhancer starr_36172 Neighboring gene STARR-seq mESC enhancer starr_36173 Neighboring gene potassium large conductance calcium-activated channel, subfamily M, alpha member 1 Neighboring gene 40S ribosomal protein S25 pseudogene Neighboring gene predicted gene, 53837

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The Transient Receptor Potential Vanilloid 2 (TRPV2) Channel Facilitates Virus Infection Through the Ca(2+) -LRMDA Axis in Myeloid Cells. Guo YY, et al. Adv Sci (Weinh), 2022 Dec. PMID 36261399, Free PMC Article
    2. Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord. Tamplin OJ, et al. Dev Biol, 2011 Dec 15. PMID 22008794
    3. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Transient Receptor Potential Vanilloid 2 (TRPV2) Channel Facilitates Virus Infection Through the Ca[2+] -LRMDA Axis in Myeloid Cells.
      Title: The Transient Receptor Potential Vanilloid 2 (TRPV2) Channel Facilitates Virus Infection Through the Ca(2+) -LRMDA Axis in Myeloid Cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in melanocyte differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in melanocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in melanocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich melanocyte differentiation-associated protein
    Names
    leucine-rich repeat-containing protein C10orf11 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028275.1 → NP_082551.1  leucine-rich melanocyte differentiation-associated protein

      See identical proteins and their annotated locations for NP_082551.1

      Status: VALIDATED

      Source sequence(s)
      AK007175, BY516672
      Consensus CDS
      CCDS49415.1
      UniProtKB/Swiss-Prot
      Q9D9B4
      Related
      ENSMUSP00000075065.5, ENSMUST00000075639.11
      Conserved Domains (4) summary
      cd00116
      Location:27 → 111
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:34 → 54
      LRR_1; leucine-rich repeat [structural motif]
      pfam12799
      Location:54 → 93
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:53 → 112
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      22069567..23106161
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519679.5 → XP_006519742.1  leucine-rich melanocyte differentiation-associated protein isoform X5

      Conserved Domains (1) summary
      pfam14580
      Location:44 → 70
      LRR_9; Leucine-rich repeat

    2. XM_006519680.5 → XP_006519743.1  leucine-rich melanocyte differentiation-associated protein isoform X6

      UniProtKB/TrEMBL
      E0CYG4
      Conserved Domains (1) summary
      pfam14580
      Location:44 → 70
      LRR_9; Leucine-rich repeat

    3. XM_036158898.1 → XP_036014791.1  leucine-rich melanocyte differentiation-associated protein isoform X2

      Conserved Domains (2) summary
      sd00031
      Location:34 → 54
      LRR_1; leucine-rich repeat [structural motif]
      pfam14580
      Location:23 → 159
      LRR_9; Leucine-rich repeat

    4. XM_006519676.5 → XP_006519739.1  leucine-rich melanocyte differentiation-associated protein isoform X1

      Conserved Domains (2) summary
      sd00031
      Location:34 → 54
      LRR_1; leucine-rich repeat [structural motif]
      pfam14580
      Location:21 → 159
      LRR_9; Leucine-rich repeat

    5. XM_036158899.1 → XP_036014792.1  leucine-rich melanocyte differentiation-associated protein isoform X3

      UniProtKB/TrEMBL
      E0CZ28
      Related
      ENSMUSP00000125751.2, ENSMUST00000159777.8
      Conserved Domains (2) summary
      sd00031
      Location:34 → 54
      LRR_1; leucine-rich repeat [structural motif]
      pfam14580
      Location:23 → 159
      LRR_9; Leucine-rich repeat

    6. XM_006519678.4 → XP_006519741.1  leucine-rich melanocyte differentiation-associated protein isoform X4

      Conserved Domains (2) summary
      sd00031
      Location:13 → 34
      LRR_1; leucine-rich repeat [structural motif]
      pfam14580
      Location:1 → 117
      LRR_9; Leucine-rich repeat
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D9B4.1 GenPept UniProtKB/Swiss-Prot:Q9D9B4

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