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    Antxr2 anthrax toxin receptor 2 [ Mus musculus (house mouse) ]

    Gene ID: 71914, updated on 9-Dec-2024

    Summary

    Official Symbol
    Antxr2provided by MGI
    Official Full Name
    anthrax toxin receptor 2provided by MGI
    Primary source
    MGI:MGI:1919164
    See related
    Ensembl:ENSMUSG00000029338 AllianceGenome:MGI:1919164
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CMG2; CMG-2; cI-35; 2310046B19Rik
    Summary
    Predicted to enable transmembrane signaling receptor activity. Acts upstream of or within collagen fibril organization; single fertilization; and uterus development. Located in external side of plasma membrane. Is expressed in cerebral cortex and retina. Human ortholog(s) of this gene implicated in fibroma and hyaline fibromatosis syndrome. Orthologous to human ANTXR2 (ANTXR cell adhesion molecule 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in heart adult (RPKM 13.0), subcutaneous fat pad adult (RPKM 7.8) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Antxr2 in Genome Data Viewer
    Location:
    5 E3; 5 47.77 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (98032547..98178876, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (97884688..98031017, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 54318 Neighboring gene predicted gene, 34097 Neighboring gene STARR-seq mESC enhancer starr_13694 Neighboring gene predicted gene, 57843 Neighboring gene STARR-positive B cell enhancer mm9_chr5:98447233-98447534 Neighboring gene predicted gene, 34226 Neighboring gene predicted gene 42759 Neighboring gene nuclear encoded tRNA lysine 8 (anticodon CTT) Neighboring gene STARR-seq mESC enhancer starr_13695 Neighboring gene predicted gene 8041

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (5)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133738.3NP_598499.1  anthrax toxin receptor 2 precursor

      See identical proteins and their annotated locations for NP_598499.1

      Status: VALIDATED

      Source sequence(s)
      AC125131, AC133519
      Consensus CDS
      CCDS39177.1
      UniProtKB/Swiss-Prot
      Q6DFX2, Q99L17
      UniProtKB/TrEMBL
      A0A0G2JE26, Q3TCL6
      Related
      ENSMUSP00000031281.10, ENSMUST00000031281.14
      Conserved Domains (3) summary
      cd01474
      Location:39221
      vWA_ATR; ATR (Anthrax Toxin Receptor): Anthrax toxin is a key virulence factor for Bacillus anthracis, the causative agent of anthrax. ATR is the cellular receptor for the anthrax protective antigen and facilitates entry of the toxin into cells. The VWA domain in ...
      pfam05586
      Location:394485
      Ant_C; Anthrax receptor C-terminus region
      pfam05587
      Location:223317
      Anth_Ig; Anthrax receptor extracellular domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      98032547..98178876 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)