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    Rps6kl1 ribosomal protein S6 kinase-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 238323, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rps6kl1provided by MGI
    Official Full Name
    ribosomal protein S6 kinase-like 1provided by MGI
    Primary source
    MGI:MGI:2443413
    See related
    Ensembl:ENSMUSG00000019235 AllianceGenome:MGI:2443413
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A830084F09Rik
    Summary
    Predicted to enable ATP binding activity; histone H2AS1 kinase activity; and protein serine kinase activity. Predicted to be involved in chromatin remodeling and protein phosphorylation. Predicted to be located in ribosome. Predicted to be part of ribonucleoprotein complex. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system gland; hindlimb mesenchyme; and nervous system. Orthologous to human RPS6KL1 (ribosomal protein S6 kinase like 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E18 (RPKM 11.8), cortex adult (RPKM 9.0) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rps6kl1 in Genome Data Viewer
    Location:
    12 D1; 12 39.57 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (85182023..85198052, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (85135249..85151277, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene prospero homeobox 2 opposite strand Neighboring gene prospero homeobox 2 Neighboring gene dihydrolipoamide S-succinyltransferase Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:86464102-86464289 Neighboring gene STARR-seq mESC enhancer starr_32766 Neighboring gene placental growth factor Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex 3 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. Sundberg JP, et al. PLoS One, 2017. PMID 28700664, Free PMC Article
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC38756

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal protein S6 kinase-like 1
    NP_001351244.1
    NP_001351245.1
    NP_001351246.1
    NP_666356.2
    XP_006515911.1
    XP_006515912.1
    XP_030102567.1
    XP_030102568.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364315.1 → NP_001351244.1  ribosomal protein S6 kinase-like 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC127582, AK031847
      Conserved Domains (2) summary
      cd02677
      Location:48 → 122
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:148 → 535
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

    2. NM_001364316.1 → NP_001351245.1  ribosomal protein S6 kinase-like 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC127582
      Conserved Domains (2) summary
      cd02677
      Location:48 → 112
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:138 → 525
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

    3. NM_001364317.1 → NP_001351246.1  ribosomal protein S6 kinase-like 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC127582
      Conserved Domains (2) summary
      cd02677
      Location:48 → 122
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:148 → 518
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

    4. NM_146244.4 → NP_666356.2  ribosomal protein S6 kinase-like 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK044050, BY124367, BY651033
      Consensus CDS
      CCDS36496.1
      UniProtKB/Swiss-Prot
      Q8R1D4, Q8R2S1
      Related
      ENSMUSP00000152336.2, ENSMUST00000221972.2
      Conserved Domains (2) summary
      cd02677
      Location:48 → 122
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:148 → 534
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      85182023..85198052 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246708.2 → XP_030102568.1  ribosomal protein S6 kinase-like 1 isoform X4

      UniProtKB/TrEMBL
      A0A217FL57
      Conserved Domains (2) summary
      cd02677
      Location:48 → 112
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:138 → 508
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

    2. XM_006515849.5 → XP_006515912.1  ribosomal protein S6 kinase-like 1 isoform X3

      UniProtKB/TrEMBL
      A0A217FL57
      Related
      ENSMUSP00000019379.9, ENSMUST00000019379.9
      Conserved Domains (2) summary
      cd02677
      Location:48 → 112
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:138 → 509
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

    3. XM_030246707.2 → XP_030102567.1  ribosomal protein S6 kinase-like 1 isoform X1

      Conserved Domains (2) summary
      cd02677
      Location:48 → 112
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:138 → 524
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

    4. XM_006515848.5 → XP_006515911.1  ribosomal protein S6 kinase-like 1 isoform X2

      Conserved Domains (2) summary
      cd02677
      Location:48 → 122
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:148 → 519
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R2S1.1 GenPept UniProtKB/Swiss-Prot:Q8R2S1

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