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    Hspd1 heat shock protein 1 (chaperonin) [ Mus musculus (house mouse) ]

    Gene ID: 15510, updated on 9-Dec-2024

    Summary

    Official Symbol
    Hspd1provided by MGI
    Official Full Name
    heat shock protein 1 (chaperonin)provided by MGI
    Primary source
    MGI:MGI:96242
    See related
    Ensembl:ENSMUSG00000025980 AllianceGenome:MGI:96242
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    60kDa; CPN60; Hsp60; HSP-60; HSP-65
    Summary
    Enables lipopolysaccharide binding activity. Involved in positive regulation of T cell activation and positive regulation of type II interferon production. Acts upstream of or within T cell activation; cellular response to interleukin-7; and positive regulation of interferon-alpha production. Located in migrasome; secretory granule; and sperm plasma membrane. Is active in mitochondrion. Is expressed in several structures, including brain; eye; heart; and urinary system. Used to study hereditary spastic paraplegia 13. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autistic disorder; glucose intolerance; hereditary spastic paraplegia (multiple); and hypomyelinating leukodystrophy 4. Orthologous to human HSPD1 (heat shock protein family D (Hsp60) member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in placenta adult (RPKM 119.5), liver E14 (RPKM 114.0) and 21 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Hspd1 in Genome Data Viewer
    Location:
    1 C1.2; 1 28.01 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (55116992..55127402, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (55077833..55088243, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene splicing factor 3b, subunit 1 Neighboring gene STARR-seq mESC enhancer starr_00942 Neighboring gene STARR-seq mESC enhancer starr_00943 Neighboring gene coenzyme Q10B Neighboring gene ribosomal protein S2 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7728 Neighboring gene heat shock protein 1 (chaperonin 10) Neighboring gene STARR-seq mESC enhancer starr_00944 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene serine/arginine repetitive matrix 2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
     
    enables apolipoprotein A-I binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables apolipoprotein A-I binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables apolipoprotein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables high-density lipoprotein particle binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables high-density lipoprotein particle binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables lipopolysaccharide binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables lipopolysaccharide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables p53 binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-folding chaperone binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in B cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in B cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in MyD88-dependent toll-like receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in MyD88-dependent toll-like receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in T cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within T cell activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within T cell activation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within T cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    NOT involved_in adhesion of symbiont to host IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in apoptotic mitochondrial changes IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in apoptotic mitochondrial changes ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in biological process involved in interaction with symbiont IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in biological process involved in interaction with symbiont ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to interleukin-7 IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of interferon-alpha production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in isotype switching to IgG isotypes IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in isotype switching to IgG isotypes ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrial unfolded protein response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process in bone marrow cell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of reactive oxygen species biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of T cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of T cell activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of T cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of T cell mediated immune response to tumor cell IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of T cell mediated immune response to tumor cell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interferon-alpha production IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of interferon-alpha production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of interferon-alpha production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-10 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of interleukin-10 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-12 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of interleukin-12 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-6 production IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of interleukin-6 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of macrophage activation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of macrophage activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of type II interferon production IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of type II interferon production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of type II interferon production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of type II interferon production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of type II interferon production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of type II interferon production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein import into mitochondrial intermembrane space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein refolding IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein refolding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein stabilization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to cold ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to unfolded protein IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to unfolded protein ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of type II interferon production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of type II interferon production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi cisterna ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
     
    located_in clathrin-coated pit ISO
    Inferred from Sequence Orthology
    more info
     
    located_in coated vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in coated vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular exosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of lipopolysaccharide receptor complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of lipopolysaccharide receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in migrasome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial crista ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial inner membrane HDA PubMed 
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in myelin sheath HDA PubMed 
    located_in peroxisomal matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in secretory granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in secretory granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sperm midpiece IEA
    Inferred from Electronic Annotation
    more info
     
    located_in sperm plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in zymogen granule ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    60 kDa heat shock protein, mitochondrial
    Names
    60 kDa chaperonin
    chaperonin 60
    heat shock 60kDa protein 1 (chaperonin)
    heat shock protein 60
    heat shock protein, 60 kDa
    mitochondrial matrix protein P1
    NP_001343441.1
    NP_034607.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356512.1NP_001343441.1  60 kDa heat shock protein, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      AC108391
      Consensus CDS
      CCDS35569.1
      UniProtKB/Swiss-Prot
      P19226, P19227, P63038, P97602, Q3KQP2, Q3UIP0, Q8C2C7, Q8VEF4
      Conserved Domains (1) summary
      cd03344
      Location:28548
      GroEL; GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found ...
    2. NM_010477.4NP_034607.3  60 kDa heat shock protein, mitochondrial

      See identical proteins and their annotated locations for NP_034607.3

      Status: VALIDATED

      Source sequence(s)
      AK143882, BF607107, BY014148
      Consensus CDS
      CCDS35569.1
      UniProtKB/Swiss-Prot
      P19226, P19227, P63038, P97602, Q3KQP2, Q3UIP0, Q8C2C7, Q8VEF4
      Related
      ENSMUSP00000027123.9, ENSMUST00000027123.15
      Conserved Domains (1) summary
      cd03344
      Location:28548
      GroEL; GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      55116992..55127402 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)