Camk4 calcium/calmodulin-dependent protein kinase IV [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Camk4provided by MGI
Official Full Name: calcium/calmodulin-dependent protein kinase IVprovided by MGI
Primary source: MGI:MGI:88258
See related: Ensembl:ENSMUSG00000038128 AllianceGenome:MGI:88258
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CaMKIV; CaMKIV/Gr; D18Bwg0362e; A430110E23Rik
Summary: Predicted to enable calcium-dependent protein serine/threonine kinase activity; calcium/calmodulin-dependent protein kinase activity; and calmodulin binding activity. Involved in postsynapse to nucleus signaling pathway and postsynaptic modulation of chemical synaptic transmission. Acts upstream of or within several processes, including neuron-neuron synaptic transmission; positive regulation of DNA-templated transcription; and positive regulation of protein export from nucleus. Located in cytoplasm and nucleus. Is active in GABA-ergic synapse and glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in cocaine dependence. Orthologous to human CAMK4 (calcium/calmodulin dependent protein kinase IV). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cerebellum adult (RPKM 21.8), cortex adult (RPKM 9.3) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 B1; 18 18.15 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (33067995..33328820)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (32934941..33195767)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CaMK4 controls follicular helper T cell expansion and function during normal and autoimmune T-dependent B cell responses.
Title: CaMK4 controls follicular helper T cell expansion and function during normal and autoimmune T-dependent B cell responses.
Calcium/calmodulin dependent protein kinase IV in trophoblast cells under insulin resistance: functional and metabolomic analyses.
Title: Calcium/calmodulin dependent protein kinase IV in trophoblast cells under insulin resistance: functional and metabolomic analyses.
CaMK4 overexpression in polycystic kidney disease promotes mTOR-mediated cell proliferation.
Title: CaMK4 overexpression in polycystic kidney disease promotes mTOR-mediated cell proliferation.
CaMK4 Promotes Acute Lung Injury Through NLRP3 Inflammasome Activation in Type II Alveolar Epithelial Cell.
Title: CaMK4 Promotes Acute Lung Injury Through NLRP3 Inflammasome Activation in Type II Alveolar Epithelial Cell.
Calcium/calmodulin-dependent protein kinase IV regulates vascular autophagy and insulin signaling through Akt/mTOR/CREB pathway in ob/ob mice.
Title: Calcium/calmodulin-dependent protein kinase IV regulates vascular autophagy and insulin signaling through Akt/mTOR/CREB pathway in ob/ob mice.
Aberrantly glycosylated IgG elicits pathogenic signaling in podocytes and signifies lupus nephritis.
Title: Aberrantly glycosylated IgG elicits pathogenic signaling in podocytes and signifies lupus nephritis.
CaMKIV regulates mitochondrial dynamics during sepsis.
Title: CaMKIV regulates mitochondrial dynamics during sepsis.
CAMKK2-CAMK4 signaling regulates transferrin trafficking, turnover, and iron homeostasis.
Title: CAMKK2-CAMK4 signaling regulates transferrin trafficking, turnover, and iron homeostasis.
CaMK4-dependent phosphorylation of Akt/mTOR underlies Th17 excessive activation in experimental autoimmune prostatitis.
Title: CaMK4-dependent phosphorylation of Akt/mTOR underlies Th17 excessive activation in experimental autoimmune prostatitis.
CaMKIV limits metabolic damage through induction of hepatic autophagy by CREB in obese mice.
Title: CaMKIV limits metabolic damage through induction of hepatic autophagy by CREB in obese mice.

Submit: New GeneRIF Correction See all GeneRIFs (52)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D18Mit63 (e-PCR), detects polymorphism
- UniSTS:128281

D18Mit96 (e-PCR), detects polymorphism
- UniSTS:128310

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

X58995 (e-PCR)
- UniSTS:125810

AI666733 (e-PCR)
- UniSTS:181107

Camk4 (e-PCR), detects polymorphism
- UniSTS:526967

PMC141152P2 (e-PCR)
- UniSTS:270993

Camk4 (e-PCR), detects polymorphism
- UniSTS:141222

NoName (e-PCR)
- UniSTS:237767

NoName (e-PCR)
- UniSTS:237768

D18Mit226 (e-PCR), detects polymorphism
- UniSTS:128245

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium/calmodulin-dependent protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium/calmodulin-dependent protein kinase activity	ISO Inferred from Sequence Orthology more info
enables calcium/calmodulin-dependent protein kinase activity	TAS Traceable Author Statement more info	PubMed
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in long-term memory	ISO Inferred from Sequence Orthology more info
involved_in long-term memory	ISS Inferred from Sequence or Structural Similarity more info
involved_in myeloid dendritic cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in myeloid dendritic cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within neuron-neuron synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nucleocytoplasmic transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein export from nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynapse to nucleus signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynapse to nucleus signaling pathway	IEP Inferred from Expression Pattern more info	PubMed
involved_in postsynapse to nucleus signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in postsynaptic modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynaptic modulation of chemical synaptic transmission	IEP Inferred from Expression Pattern more info	PubMed
involved_in postsynaptic modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in GABA-ergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in postsynapse	IEA Inferred from Electronic Annotation more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: calcium/calmodulin-dependent protein kinase type IV

Names: CAM kinase-GR; Ca2+/calmodulin-dependent protein kinase type IV/Gr; caMK IV

NP_033923.2

EC 2.7.11.17

XP_006525606.1

EC 2.7.11.17

XP_006525607.1

EC 2.7.11.17

XP_006525609.1

EC 2.7.11.17

XP_030106157.1

EC 2.7.11.17

XP_030106158.1

EC 2.7.11.17

XP_036016846.1

EC 2.7.11.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009793.3 → NP_033923.2 calcium/calmodulin-dependent protein kinase type IV

See identical proteins and their annotated locations for NP_033923.2

Status: VALIDATED

Source sequence(s)

AC114919, BC070420, CJ104330

Consensus CDS

CCDS29122.1

UniProtKB/Swiss-Prot

P08414, Q61381

UniProtKB/TrEMBL

Q8BGR3

Related

ENSMUSP00000046539.5, ENSMUST00000042868.6

Conserved Domains (1) summary

cd14085
Location:38 → 331

STKc_CaMKIV; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type IV

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

33067995..33328820

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006525544.5 → XP_006525607.1 calcium/calmodulin-dependent protein kinase type IV isoform X2

See identical proteins and their annotated locations for XP_006525607.1

UniProtKB/Swiss-Prot

P08414, Q61381

UniProtKB/TrEMBL

Q8BGR3

Related

ENSMUSP00000157216.2, ENSMUST00000234654.2

Conserved Domains (1) summary

cd14085
Location:38 → 331

STKc_CaMKIV; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type IV
XM_030250297.2 → XP_030106157.1 calcium/calmodulin-dependent protein kinase type IV isoform X2

UniProtKB/Swiss-Prot

P08414, Q61381

UniProtKB/TrEMBL

Q8BGR3

Conserved Domains (1) summary

cd14085
Location:38 → 331

STKc_CaMKIV; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type IV
XM_006525543.3 → XP_006525606.1 calcium/calmodulin-dependent protein kinase type IV isoform X1

UniProtKB/Swiss-Prot

P08414, Q61381

Conserved Domains (1) summary

cd14085
Location:66 → 359

STKc_CaMKIV; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type IV
XM_030250298.2 → XP_030106158.1 calcium/calmodulin-dependent protein kinase type IV isoform X3

Conserved Domains (2) summary

pfam04698
Location:200 → 251

Rab_eff_C; Rab effector MyRIP/melanophilin C-terminus

cl21453
Location:1 → 138

PKc_like; Protein Kinases, catalytic domain
XM_006525546.5 → XP_006525609.1 calcium/calmodulin-dependent protein kinase type IV isoform X2

See identical proteins and their annotated locations for XP_006525609.1

UniProtKB/Swiss-Prot

P08414, Q61381

UniProtKB/TrEMBL

Q8BGR3

Conserved Domains (1) summary

cd14085
Location:38 → 331

STKc_CaMKIV; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type IV
XM_036160953.1 → XP_036016846.1 calcium/calmodulin-dependent protein kinase type IV isoform X3

Conserved Domains (2) summary

pfam04698
Location:200 → 251

Rab_eff_C; Rab effector MyRIP/melanophilin C-terminus

cl21453
Location:1 → 138

PKc_like; Protein Kinases, catalytic domain