Trim60 tripartite motif-containing 60 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trim60provided by MGI
Official Full Name: tripartite motif-containing 60provided by MGI
Primary source: MGI:MGI:2387430
See related: Ensembl:ENSMUSG00000053490 AllianceGenome:MGI:2387430
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rnf33; 2czf45
Summary: Predicted to enable SUMO-ubiquitin ligase activity and ubiquitin protein ligase activity. Predicted to be involved in innate immune response and negative regulation of non-canonical NF-kappaB signal transduction. Predicted to be active in cytosol. Is expressed in central nervous system; early conceptus; gonad; and urinary system. Orthologous to human TRIM60 (tripartite motif containing 60). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 8 B3.1; 8 32.51 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (65451100..65471340, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (64998448..65018688, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The SUMOylation of TAB2 mediated by TRIM60 inhibits MAPK/NF-kappaB activation and the innate immune response.
Title: The SUMOylation of TAB2 mediated by TRIM60 inhibits MAPK/NF-κB activation and the innate immune response.
the first demonstration of a TRIM protein, RNF33, interacting with kinesin molecular motors, possibly contributing to kinesin-dependent mobilization along the microtubule in the testis of the mouse
Title: Association of the testis-specific TRIM/RBCC protein RNF33/TRIM60 with the cytoplasmic motor proteins KIF3A and KIF3B.
Regulation of transcription and pre-mRNA processing of Rnf33 in eggs and in pre-implantation embryos
Title: Different modes of regulation of transcription and pre-mRNA processing of the structurally juxtaposed homologs, Rnf33 and Rnf35, in eggs and in pre-implantation embryos.
Rnf33 and Rnf35 mRNAs are apparently transcribed from the same putative promoter and may be products of alternative splicing.
Title: Use of a common promoter by two juxtaposed and intronless mouse early embryonic genes, Rnf33 and Rnf35: implications in zygotic gene expression.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1)

General gene information

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Markers

RH136249 (e-PCR)
- UniSTS:210243

NoName (e-PCR)
- UniSTS:235900

NoName (e-PCR)
- UniSTS:235901

NoName (e-PCR)
- UniSTS:235902

RH127152 (e-PCR)
- UniSTS:208286

RH124364 (e-PCR)
- UniSTS:161186

Trim61 (e-PCR), detects polymorphism
- UniSTS:256956

Rnf35 (e-PCR), detects polymorphism
- UniSTS:256957

PMC137171P1 (e-PCR)
- UniSTS:270819

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SUMO-ubiquitin ligase activity	IEA Inferred from Electronic Annotation more info
enables SUMO-ubiquitin ligase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of non-canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: E3 SUMO-protein ligase TRIM60

Names: ring finger protein 33; tripartite motif-containing protein 60

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153097.2 → NP_694737.1 E3 SUMO-protein ligase TRIM60

See identical proteins and their annotated locations for NP_694737.1

Status: VALIDATED

Source sequence(s)

AC164589, AK135841, CA561473

Consensus CDS

CCDS22331.1

UniProtKB/Swiss-Prot

Q3UX74, Q8VI40

UniProtKB/TrEMBL

B2RTP1

Related

ENSMUSP00000040299.8, ENSMUST00000048565.9

Conserved Domains (3) summary

cd00021
Location:94 → 132

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

cd15828
Location:281 → 457

SPRY_PRY_TRIM60; PRY/SPRY domain of tripartite motif-binding protein 60 (TRIM60) also known as RING finger protein 33 (RNF33)

cl17238
Location:15 → 55

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...